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    Branched highly-functional monomers exhibiting low polymerization shrinkage
    3.
    发明申请
    Branched highly-functional monomers exhibiting low polymerization shrinkage 审中-公开
    表现出低聚合收缩率的支链高官能单体

    公开(公告)号：US20050124722A1

    公开(公告)日：2005-06-09

    申请号：US10937706

    申请日：2004-09-08

    申请人： Samuel Arthur ,  Charles Brandenburg

    发明人： Samuel Arthur ,  Charles Brandenburg

    IPC分类号： A61K6/083 ,  C07C43/11 ,  C07C69/54 ,  A61F2/00 ,  C07C69/74

    CPC分类号： C07C69/54 ,  A61K6/0017 ,  A61K6/0023 ,  A61K6/083 ,  C08L33/00

    摘要： The invention relates to (meth)acrylate monomers derived from polyfunctional nucleus molecules; the invention further relates to a dental composite material wherein (meth)acrylate monomers are utilized to reduce shrinkage upon polymerization; the invention also relates to a method for producing dental restoration articles with reduced shrinkage; the invention also relates to various dental restorative articles comprising the aforementioned (meth)acrylate monomers.

    摘要翻译： 本发明涉及衍生自多官能核分子的（甲基）丙烯酸酯单体; 本发明还涉及一种牙科复合材料，其中（甲基）丙烯酸酯单体用于减少聚合时的收缩; 本发明还涉及一种减少收缩的牙科修复物的制造方法; 本发明还涉及包含上述（甲基）丙烯酸酯单体的各种牙科修复制品。

    Aldol-crosslinked polymeric hydrogel adhesives
    6.
    发明申请
    Aldol-crosslinked polymeric hydrogel adhesives 有权
    醛交联聚合物水凝胶粘合剂

    公开(公告)号：US20070048337A1

    公开(公告)日：2007-03-01

    申请号：US11509151

    申请日：2006-08-24

    申请人： Samuel Arthur

    发明人： Samuel Arthur

    IPC分类号： A61K9/14

    CPC分类号： A61K9/06

    摘要： Adhesives formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. The use of the adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described. The adhesive may also be used for industrial and consumer applications.

    摘要翻译： 公开了在碱催化剂存在下使氧化多糖与用乙酰乙酸酯基团衍生的聚（羟基）化合物反应形成的粘合剂。 用于医疗和兽医应用的粘合剂如局部伤口闭合; 和外科手术，如肠吻合，血管吻合，组织修复和眼科手术; 并描述药物递送。 粘合剂也可用于工业和消费者应用。

    Method for preparing para-(2-hydroxyalkyloxy) styrene monomers and oligomers
    7.
    发明申请
    Method for preparing para-(2-hydroxyalkyloxy) styrene monomers and oligomers 失效
    对 - （2-羟基烷氧基）苯乙烯单体和低聚物的制备方法

    公开(公告)号：US20050234266A1

    公开(公告)日：2005-10-20

    申请号：US11057589

    申请日：2005-02-14

    申请人： Samuel Arthur ,  Keith Kunitsky ,  Barry Trost ,  Mark Wagman

    发明人： Samuel Arthur ,  Keith Kunitsky ,  Barry Trost ,  Mark Wagman

    IPC分类号： C07C41/00 ,  C07C41/03 ,  C07C43/23

    CPC分类号： C07C41/03 ,  C08F12/22 ,  C07C43/23

    摘要： A method for preparing p-(2-hydroxyalkyloxy)styrene monomers and oligomers is described. The method comprises a base-catalyzed reaction of a styrene ester, a suitable alcohol and an alkylene oxide in a single vessel reaction. In this method, the reactive p-hydroxystyrene is generated in situ via the base-catalyzed transesterification reaction between the styrene ester and the alcohol in the presence of the base catalyst. The p-hydroxystyrene formed reacts with the alkylene oxide to form the p-(2-hydroxyalkyloxy)styrene monomer or oligomer.

    摘要翻译： 描述了制备对 - （2-羟基烷氧基）苯乙烯单体和低聚物的方法。 该方法包括在单容器反应中苯乙烯酯，合适的醇和烯化氧的碱催化反应。 在该方法中，在碱催化剂存在下，通过苯乙烯酯与醇之间的碱催化酯交换反应原位生成反应性对羟基苯乙烯。 所形成的对羟基苯乙烯与烯化氧反应形成对 - （2-羟基烷氧基）苯乙烯单体或低聚物。

    Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive
    8.
    发明申请
    Methods for sealing an orifice in tissue using an aldol-crosslinked polymeric hydrogel adhesive 有权
    使用醛醇交联聚合物水凝胶粘合剂密封组织中孔口的方法

    公开(公告)号：US20070048251A1

    公开(公告)日：2007-03-01

    申请号：US11509255

    申请日：2006-08-24

    申请人： Samuel Arthur

    发明人： Samuel Arthur

    IPC分类号： A61K31/765

    CPC分类号： A61K31/765 ,  C08L5/02 ,  C08L5/08 ,  C08L29/04 ,  C08L2666/26 ,  C09J129/04 ,  C08L2666/04

    摘要： Methods for sealing an orifice in tissue in the body of a living animal using an adhesive formed by reacting an oxidized polysaccharide with a poly(hydroxylic) compound derivatized with acetoacetate groups in the presence of a base catalyst are disclosed. Methods for using the adhesive for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; and drug delivery are described.

    摘要翻译： 公开了使用氧化多糖与在乙酰乙酸酯基团衍生的聚（羟基）化合物在碱催化剂存在下反应形成的粘合剂来密封活体动物体内组织中孔的方法。 用于医疗和兽医应用的粘合剂的方法，例如局部伤口闭合; 和外科手术，如肠吻合，血管吻合，组织修复和眼科手术; 并描述药物递送。

    Polymer-based tissue-adhesive form medical use
    9.
    发明申请
    Polymer-based tissue-adhesive form medical use 有权
    基于聚合物的组织粘合剂形成医疗用途

    公开(公告)号：US20060079599A1

    公开(公告)日：2006-04-13

    申请号：US11244758

    申请日：2005-10-05

    申请人： Samuel Arthur

    发明人： Samuel Arthur

    IPC分类号： A61K6/00

    CPC分类号： A61L24/046 ,  A61L24/0031 ,  A61L24/043

    摘要： Tissue adhesives formed by reacting poly(hydroxylic) compounds derivatized with acetoacetate groups and/or polyamino compounds derivatized with acetoacetamide groups with an amino-functional crosslinking compound are disclosed. The use of the tissue adhesives for medical and veterinary applications such as topical wound closure; and surgical procedures, such as intestinal anastomosis, vascular anastomosis, tissue repair, and ophthalmic procedures; drug delivery; and anti-adhesive applications are described.

    摘要翻译： 公开了通过将由乙酰乙酸酯基团衍生的聚（羟基）化合物和/或用乙酰乙酰胺基团衍生的聚氨基化合物与氨基官能交联化合物反应形成的组织粘合剂。 使用组织粘合剂进行医疗和兽医应用，如局部伤口闭合; 和外科手术，如肠吻合，血管吻合，组织修复和眼科手术; 药物递送 并描述了防粘连的应用。