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    Method for preparing para-(2-hydroxyalkyloxy) styrene monomers and oligomers
    1.
    发明申请
    Method for preparing para-(2-hydroxyalkyloxy) styrene monomers and oligomers 失效
    对 - （2-羟基烷氧基）苯乙烯单体和低聚物的制备方法

    公开(公告)号：US20050234266A1

    公开(公告)日：2005-10-20

    申请号：US11057589

    申请日：2005-02-14

    申请人： Samuel Arthur ,  Keith Kunitsky ,  Barry Trost ,  Mark Wagman

    发明人： Samuel Arthur ,  Keith Kunitsky ,  Barry Trost ,  Mark Wagman

    IPC分类号： C07C41/00 ,  C07C41/03 ,  C07C43/23

    CPC分类号： C07C41/03 ,  C08F12/22 ,  C07C43/23

    摘要： A method for preparing p-(2-hydroxyalkyloxy)styrene monomers and oligomers is described. The method comprises a base-catalyzed reaction of a styrene ester, a suitable alcohol and an alkylene oxide in a single vessel reaction. In this method, the reactive p-hydroxystyrene is generated in situ via the base-catalyzed transesterification reaction between the styrene ester and the alcohol in the presence of the base catalyst. The p-hydroxystyrene formed reacts with the alkylene oxide to form the p-(2-hydroxyalkyloxy)styrene monomer or oligomer.

    摘要翻译： 描述了制备对 - （2-羟基烷氧基）苯乙烯单体和低聚物的方法。 该方法包括在单容器反应中苯乙烯酯，合适的醇和烯化氧的碱催化反应。 在该方法中，在碱催化剂存在下，通过苯乙烯酯与醇之间的碱催化酯交换反应原位生成反应性对羟基苯乙烯。 所形成的对羟基苯乙烯与烯化氧反应形成对 - （2-羟基烷氧基）苯乙烯单体或低聚物。

    Method for preparing para-(2-hydroxyalkyloxy) styrene monomers and oligomers
    4.
    发明授权
    Method for preparing para-(2-hydroxyalkyloxy) styrene monomers and oligomers 失效
    对 - （2-羟基烷氧基）苯乙烯单体和低聚物的制备方法

    公开(公告)号：US07199272B2

    公开(公告)日：2007-04-03

    申请号：US11057589

    申请日：2005-02-14

    申请人： Samuel David Arthur ,  Keith Kunitsky ,  Barry M. Trost ,  Mark E. Wagman

    发明人： Samuel David Arthur ,  Keith Kunitsky ,  Barry M. Trost ,  Mark E. Wagman

    IPC分类号： C07C41/03

    CPC分类号： C07C41/03 ,  C08F12/22 ,  C07C43/23

    摘要： A method for preparing p-(2-hydroxyalkyloxy)styrene monomers and oligomers is described. The method comprises a base-catalyzed reaction of a styrene ester, a suitable alcohol and an alkylene oxide in a single vessel reaction. In this method, the reactive p-hydroxystyrene is generated in situ via the base-catalyzed transesterification reaction between the styrene ester and the alcohol in the presence of the base catalyst. The p-hydroxystyrene formed reacts with the alkylene oxide to form the p-(2-hydroxyalkyloxy)styrene monomer or oligomer.

    摘要翻译： 描述了制备对 - （2-羟基烷氧基）苯乙烯单体和低聚物的方法。 该方法包括在单容器反应中苯乙烯酯，合适的醇和烯化氧的碱催化反应。 在该方法中，在碱催化剂存在下，通过苯乙烯酯与醇之间的碱催化酯交换反应原位生成反应性对羟基苯乙烯。 所形成的对羟基苯乙烯与烯化氧反应形成对 - （2-羟基烷氧基）苯乙烯单体或低聚物。

    HYDROGEL TISSUE ADHESIVE HAVING INCREASED DEGRADATION TIME
    5.
    发明申请
    HYDROGEL TISSUE ADHESIVE HAVING INCREASED DEGRADATION TIME 审中-公开
    HYDROGEL TISSUE粘合剂具有降低的降解时间

    公开(公告)号：US20100160960A1

    公开(公告)日：2010-06-24

    申请号：US12614659

    申请日：2009-11-09

    申请人： Mark E. Wagman ,  Kai Qi ,  Keith Kunitsky ,  Hing Wan Yim

    发明人： Mark E. Wagman ,  Kai Qi ,  Keith Kunitsky ,  Hing Wan Yim

    IPC分类号： A61B17/03 ,  C08K5/05 ,  C08L5/00

    CPC分类号： A61L24/0031 ,  A61B17/00491 ,  A61L24/08 ,  C08B37/0021 ,  C08G2650/50 ,  C08J3/075 ,  C08L71/02 ,  C08L2205/05 ,  C08L5/00

    摘要： A hydrogel tissue adhesive having increased degradation time is described. The hydrogel tissue adhesive is formed by reacting an oxidized polysaccharide with a water-dispersible, multi-arm amine in the presence of a polyol additive, which retards the degradation of the hydrogel. The hydrogel may be useful as a tissue adhesive or sealant for medical applications, including but not limited to, ophthalmic applications such as sealing wounds resulting from trauma such as corneal lacerations, or from surgical procedures such as vitrectomy procedures, cataract surgery, LASIK surgery, glaucoma surgery, and corneal transplants; neurosurgery applications, such as sealing the dura; as a plug to seal a fistula or the punctum; adhesion prevention to prevent undesired tissue to tissue adhesions resulting from trauma or surgery; and as a hemostat sealant.

    摘要翻译： 描述了具有增加的降解时间的水凝胶组织粘合剂。 通过在多元醇添加剂的存在下使氧化多糖与水分散性多臂胺反应形成水凝胶组织粘合剂，其延缓了水凝胶的降解。 水凝胶可用作用于医疗应用的组织粘合剂或密封剂，包括但不限于眼科应用，例如由诸如角膜撕裂等创伤引起的伤口，或外科手术如玻璃体切除术，白内障手术，LASIK手术， 青光眼手术和角膜移植; 神经外科应用如密封硬脑膜; 作为密封瘘管或泪点的塞子; 防止粘附以防止由创伤或手术导致的不想要的组织到组织粘连; 并作为止血剂密封胶。

    Method for preparing glycidyloxystyrene monomers and polymers thereof
    7.
    发明授权
    Method for preparing glycidyloxystyrene monomers and polymers thereof 失效
    缩水甘油氧基苯乙烯单体的制备方法及其聚合物

    公开(公告)号：US07468415B2

    公开(公告)日：2008-12-23

    申请号：US11961093

    申请日：2007-12-20

    申请人： Keith Kunitsky ,  Mukesh C. Shah ,  Steven W. Shuey ,  Mark E. Wagman

    发明人： Keith Kunitsky ,  Mukesh C. Shah ,  Steven W. Shuey ,  Mark E. Wagman

    IPC分类号： C08F2/00 ,  C07D301/28 ,  C08F12/22

    CPC分类号： C08F12/22 ,  C07D303/23

    摘要： It was found that glycidyloxystyrenes, including glycidyloxystyrene and substituted glycidyloxystyrene, can be synthesized from hydroxycinnamic acid or substituted hydroxycinnamic acids in a one-pot, two-step process. The substrate can be thermally decarboxylated and then without purification, reacted in the presence of a halomethyl-oxirane and a base. The resulting product can be polymerized or coppolymerized to a fully substituted product.

    摘要翻译： 发现缩水甘油氧基苯乙烯，包括缩水甘油氧基苯乙烯和取代的缩水甘油氧基苯乙烯，可以一锅二步法从羟基肉桂酸或取代的羟基肉桂酸合成。 底物可以热脱羧，然后不经纯化，在卤代甲基 - 环氧乙烷和碱的存在下反应。 所得产物可以被聚合或共聚合成完全取代的产物。