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公开(公告)号：US20090124662A1
公开(公告)日：2009-05-14
申请号：US11597678
申请日：2006-05-25
申请人： Samuel J. Danishefsky , Christoph Gaul , Jon T. Njardarson , Malcolm A.S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
发明人： Samuel J. Danishefsky , Christoph Gaul , Jon T. Njardarson , Malcolm A.S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
IPC分类号： A61K31/4523 , A61P35/00 , A61P25/00
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
摘要翻译： 一方面，本发明提供了一种用于治疗受试者中结肠和/或卵巢癌的方法，包括向有需要的受试者施用通式（I）的化合物：其中R1-R6，R，-R，Q， Y1，Y2和n如本文所定义，其中化合物以有效抑制结肠和/或卵巢肿瘤转移的量存在。
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公开(公告)号：US08957056B2
公开(公告)日：2015-02-17
申请号：US11597678
申请日：2005-05-25
申请人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
发明人： Samuel J. Danishefsky , Christoph Gaul , Jón T. Njardarson , Malcolm A. S. Moore , Kaida Wu , David C. Dorn , Mihirbaran Mandal
IPC分类号： A61K31/395 , A61K31/335 , C07D313/00 , C07D225/02 , A61K31/365 , A61K31/435
CPC分类号： A61K31/395 , A61K31/365 , A61K31/435
摘要： In one aspect, the present invention provides a method for treating colon and/or ovarian cancer in a subject comprising administering to a subject in need thereof a compound of general formula (I): wherein R1-R6, R, -R, Q, Y1, Y2 and n are as defined herein, wherein the compound is present in an amount effective to inhibit colon and/or ovarian tumor metastasis.
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公开(公告)号：US20090054488A1
公开(公告)日：2009-02-26
申请号：US11663580
申请日：2005-09-23
IPC分类号： A61K31/4523 , C07D405/02 , A61P35/00 , A61P9/00 , A61P37/00 , A61P7/00 , A61P31/00
CPC分类号： C07D313/00
摘要： The present invention provides compounds having formula (I): (I) wherein n, R1-R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.
摘要翻译： 本发明提供具有式（I）的化合物：（I）其中n，R 1 -R 5，R a -R b，Q，Y 1和Y 2如本文所定义; 并且另外提供其合成方法，其组合物及其用于治疗包括癌症，转移和涉及增加的血管发生的病症的各种疾病的方法。
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公开(公告)号：US07943800B2
公开(公告)日：2011-05-17
申请号：US10551158
申请日：2004-03-26
IPC分类号： C07C49/587 , A61K31/12
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： The present invention provides compounds having formula (I), and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1—R6, Ra—Rc, Q, Y1, Y2 and n are as defined herein.
摘要翻译： 本发明提供具有式（I）的化合物，另外提供其合成方法，组合物及其用于治疗包括癌症，转移和涉及增加的血管发生的病症的各种疾病的方法，其中R1-R6， Ra-Rc，Q，Y1，Y2和n如本文所定义。
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公开(公告)号：US08324284B2
公开(公告)日：2012-12-04
申请号：US13106625
申请日：2011-05-12
IPC分类号： A61K31/12 , C07C49/587
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein.
摘要翻译： 本发明提供具有式（I）的化合物：另外提供其合成方法，组合物及其在治疗包括癌症，转移和涉及血管生成增加的疾病的各种疾病中的应用的方法，其中R1-R6， Ra-Rc，Q，Y1，Y2和n如本文所定义。
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公开(公告)号：US20110281916A1
公开(公告)日：2011-11-17
申请号：US13106625
申请日：2011-05-12
IPC分类号： A61K31/4427 , A61K31/365 , A61P35/04 , A61K31/4412
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： The present invention provides compounds having formula (I): and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis, wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein.
摘要翻译： 本发明提供了具有式（I）的化合物：另外提供了其合成方法，组合物及其在治疗包括癌症，转移和涉及血管生成增加的疾病的各种疾病中的应用的方法，其中R1-R6， Ra-Rc，Q，Y1，Y2和n如本文所定义。
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7.发明申请公开(公告)号：US20090149516A1
公开(公告)日：2009-06-11
申请号：US12135823
申请日：2008-06-09
申请人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A.S. Moore , David Dorn
发明人： Samuel J. Danishefsky , Alexey Rivkin , Fumihiko Yoshimura , Ting-Chao Chou , Ana E. Gabarda , Huajin Dong , Kaida Wu , Malcolm A.S. Moore , David Dorn
IPC分类号： A61K31/427 , C07D417/06 , A61P35/00
CPC分类号： C07D417/06 , C07D493/04
摘要： The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).
摘要翻译： 本发明提供式（I）化合物：如本文中一般性地和类别和亚类所述。 本发明还提供包含式（I）化合物的药物组合物，并提供治疗癌症的方法，包括施用式（I）化合物。
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公开(公告)号：US08188141B2
公开(公告)日：2012-05-29
申请号：US11663580
申请日：2005-09-23
IPC分类号： A61K31/38 , A61K31/335 , C07D337/00 , C07D309/00 , C07C49/00
CPC分类号： C07D313/00
摘要： The present invention provides compounds having formula (I): (I) wherein n, R1-R5, Ra-Rb, Q, Y1 and Y2 are as defined herein; and additionally provides methods for the synthesis thereof, compositions thereof, and methods for the use thereof in the treatment of various disorders including cancer, metastasis and disorders involving increased angiogenesis.
摘要翻译： 本发明提供具有式（I）的化合物：（I）其中n，R 1 -R 5，R a -R b，Q，Y 1和Y 2如本文所定义; 并且另外提供其合成方法，其组合物及其用于治疗包括癌症，转移和涉及增加的血管发生的病症的各种疾病的方法。
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公开(公告)号：US07531181B2
公开(公告)日：2009-05-12
申请号：US11145084
申请日：2005-06-03
CPC分类号： C07K14/005 , A61K38/00 , A61K39/12 , A61K39/21 , A61K2039/55577 , A61K2039/6018 , A61K2039/6081 , A61K2039/627 , C07K1/1077 , C07K14/375 , C07K14/505 , C12N2740/16122 , C12N2740/16134
摘要： The present invention provides multi-antigenic constructs comprising one or more carbohydrate antigens having the formula: wherein R1, R2A, R2B, R3, R4, W1, W2 and W3 are as defined herein; and additionally provides compositions thereof, and methods for their use in the treatment and/or prevention of HIV infection, and methods for inducing HIV-specific antibodies in a subject, comprising administering to a subject in need thereof, an effective amount of any of the inventive compounds as disclosed herein, either in conjugated form or unconjugated and in combination with a suitable immunogenic carrier. In another aspect, the invention provides an antibody or antibody fragment which binds specifically to a gp120 glycan or glycopeptide of the invention.
摘要翻译： 本发明提供包含一种或多种具有下式的碳水化合物抗原的多抗原构建体：其中R1，R2A，R2B，R3，R4，W1，W2和W3如本文所定义; 并且还提供其组合物及其用于治疗和/或预防HIV感染的方法，以及在受试者中诱导HIV-特异性抗体的方法，包括向有需要的受试者施用有效量的任何 本文公开的本发明化合物，其以缀合形式或未缀合并与合适的免疫原性载体组合。 另一方面，本发明提供了与本发明的gp120聚糖或糖肽特异性结合的抗体或抗体片段。
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公开(公告)号：US08202911B2
公开(公告)日：2012-06-19
申请号：US13053161
申请日：2011-03-21
IPC分类号： A61K31/12 , C07C49/587
CPC分类号： C07D313/00 , A61K31/365 , A61K31/395 , A61K31/435 , C07D225/02 , C07D405/06 , C07D495/04 , A61K2300/00
摘要： In one aspect, the present invention provides pharmaceutical compositions comprising a therapeutically effective amount of a compound of general formula (I), wherein R1-R6, Ra-Rc, Q, Y1, Y2 and n are as defined herein, whereby the composition is formulated for administration to a subject at a dosage between about 0.1 mg/kg to about 50 mg/kg of body weight. In another aspect, the present invention provides a method for treating breast tumor metastasis in a subject comprising administering to a subject in need thereof a therapeutically effective amount of the inventive composition described directly above and a pharmaceutically acceptable carrier, adjuvant or vehicle.
摘要翻译： 一方面，本发明提供包含治疗有效量的通式（I）化合物的药物组合物，其中R 1 -R 6，R a -R c，Q，Y 1，Y 2和n如本文所定义，其中组合物为 配制成以约0.1mg / kg至约50mg / kg体重的剂量施用于受试者。 另一方面，本发明提供一种用于治疗受试者的乳腺肿瘤转移的方法，其包括向有需要的受试者施用治疗有效量的上述直接描述的本发明组合物和药学上可接受的载体，佐剂或媒介物。
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