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1.发明申请Novel and Practical Serological Assay for the Clinical Diagnosis of Leishmaniasis 有权利什曼病临床诊断的新型实用血清学检测公开(公告)号：US20100092938A1
公开(公告)日：2010-04-15
申请号：US12544733
申请日：2009-08-20
Applicant: Samuel K. Martin
Inventor： Samuel K. Martin
CPC classification number: G01N33/56905 , A01N1/02 , A01N1/0221 , C12Q1/08 , Y02A50/55
Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.
Abstract translation: 公开了在疑似感染寄生原虫利什曼原虫的受试者中诊断内脏，皮肤和犬利什曼病的方法。 公开了用于检测利什曼原虫寄生虫可溶性抗原的抗体的抗体捕获酶联免疫吸附测定（ELISA）和用于检测宿主样品中利什曼原虫寄生虫可溶性抗原的抗原捕获ELISA。 还公开了用于在具有内脏，皮肤或犬利什曼病的受试者的样品中检测利什曼原虫寄生虫循环抗原或IgM和IgG抗体的免疫诊断试剂盒。 在这些方法和试剂盒中，可以通过光度或视觉方式进行检测。 方法和试剂盒还允许在样品中可视化利什曼原虫或反义具。
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公开(公告)号：US07611896B2
公开(公告)日：2009-11-03
申请号：US11150322
申请日：2005-06-13
Applicant: Samuel K. Martin
Inventor： Samuel K. Martin
CPC classification number: G01N33/56905 , A01N1/02 , A01N1/0221 , C12Q1/08 , Y02A50/55
Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.
Abstract translation: 公开了在疑似感染寄生原虫利什曼原虫的受试者中诊断内脏，皮肤和犬利什曼病的方法。 公开了用于检测利什曼原虫寄生虫可溶性抗原的抗体的抗体捕获酶联免疫吸附测定（ELISA）和用于检测宿主样品中利什曼原虫寄生虫可溶性抗原的抗原捕获ELISA。 还公开了用于在具有内脏，皮肤或犬利什曼病的受试者的样品中检测利什曼原虫寄生虫循环抗原或IgM和IgG抗体的免疫诊断试剂盒。 在这些方法和试剂盒中，可以通过光度或视觉方式进行检测。 方法和试剂盒还允许在样品中可视化利什曼原虫或反义具。
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3.发明授权Artemisinins in the clinical and veterinary management of kinetoplastid infections 失效青蒿素在动物原核生物感染的临床和兽医管理中的应用公开(公告)号：US07566465B2
公开(公告)日：2009-07-28
申请号：US11644494
申请日：2006-12-21
Applicant: Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
Inventor： Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
IPC: A61K36/282
CPC classification number: A61K31/366 , A61K31/357 , A61K36/282
Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.
Abstract translation: 本发明涉及通过施用含有来自艾蒿植物的提取物的药物组合物来治疗激素质感染。 本发明还涉及分离的，半合成的和合成的青蒿素，其在治疗动粒细胞感染中显示出改进的功效。 本发明还涉及一种用阿魏酸和青蒿素治疗激素质感染的方法，其中口服阿片ic酸。
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公开(公告)号：US07008774B2
公开(公告)日：2006-03-07
申请号：US10173586
申请日：2002-06-18
Applicant: Jeffrey R. Ryan , Samuel K. Martin , Anthony M. Smithyman
Inventor： Jeffrey R. Ryan , Samuel K. Martin , Anthony M. Smithyman
IPC: G01N33/53 , C12Q1/70 , C12Q1/69 , A61K30/005 , C07K14/00
CPC classification number: G01N33/56905 , C07K14/44 , G01N2469/20 , Y02A50/55
Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.
Abstract translation: 公开了在疑似感染寄生原虫利什曼原虫的受试者中诊断内脏，皮肤和犬利什曼病的方法。 公开了用于检测利什曼原虫寄生虫可溶性抗原的抗体的抗体捕获酶联免疫吸附测定（ELISA）和用于检测宿主样品中利什曼原虫寄生虫可溶性抗原的抗原捕获ELISA。 还公开了用于在具有内脏，皮肤或犬利什曼病的受试者的样品中检测利什曼原虫寄生虫循环抗原或IgM和IgG抗体的免疫诊断试剂盒。 在这些方法和试剂盒中，可以通过光度或视觉方式进行检测。 方法和试剂盒还允许在样品中可视化利什曼原虫或反义具。
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5.发明申请Artemisinins in the Clinical and Veterinary Management of Kinetoplastid Infextions 审中-公开青蒿素在动物体内侵袭的临床和兽医管理中的应用公开(公告)号：US20140243402A1
公开(公告)日：2014-08-28
申请号：US13999318
申请日：2014-02-04
Applicant: Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
Inventor： Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
IPC: A61K31/366 , A61K36/282
CPC classification number: A61K31/366 , A61K31/357 , A61K36/282
Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.
Abstract translation: 本发明涉及通过施用含有来自艾蒿植物的提取物的药物组合物来治疗激素质感染。 本发明还涉及分离的，半合成的和合成的青蒿素，其在治疗动粒细胞感染中显示出改进的功效。 本发明还涉及一种用阿魏酸和青蒿素治疗激素质感染的方法，其中口服阿片ic酸。
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Patent Agency Ranking
6.发明授权Method for obtaining a cellular product from a cell or a tissue using protein-free medium 有权使用无蛋白质培养基从细胞或组织获得细胞产物的方法公开(公告)号：US07993917B2
公开(公告)日：2011-08-09
申请号：US12544733
申请日：2009-08-20
Applicant: Samuel K. Martin
Inventor： Samuel K. Martin
CPC classification number: G01N33/56905 , A01N1/02 , A01N1/0221 , C12Q1/08 , Y02A50/55
Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.
Abstract translation: 公开了在疑似感染寄生原虫利什曼原虫的受试者中诊断内脏，皮肤和犬利什曼病的方法。 公开了用于检测利什曼原虫寄生虫可溶性抗原的抗体的抗体捕获酶联免疫吸附测定（ELISA）和用于检测宿主样品中利什曼原虫寄生虫可溶性抗原的抗原捕获ELISA。 还公开了用于在具有内脏，皮肤或犬利什曼病的受试者的样品中检测利什曼原虫寄生虫循环抗原或IgM和IgG抗体的免疫诊断试剂盒。 在这些方法和试剂盒中，可以通过光度或视觉方式进行检测。 方法和试剂盒还允许在样品中可视化利什曼原虫或反义具。
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7.发明授权Artemisinins in the clinical and veterinary management of kinetoplastid infections 有权青蒿素在动物原核生物感染的临床和兽医管理中的应用公开(公告)号：US08715751B2
公开(公告)日：2014-05-06
申请号：US12460289
申请日：2009-07-16
Applicant: Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
Inventor： Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
IPC: A61K36/282 , A61K36/00 , C07K16/20
CPC classification number: A61K31/366 , A61K31/357 , A61K36/282
Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.
Abstract translation: 本发明涉及通过施用含有来自艾蒿植物的提取物的药物组合物来治疗激素质感染。 本发明还涉及分离的，半合成的和合成的青蒿素，其在治疗动粒细胞感染中显示出改进的功效。 本发明还涉及一种用阿魏酸和青蒿素治疗激素质感染的方法，其中口服阿片ic酸。
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公开(公告)号：US5137294A
公开(公告)日：1992-08-11
申请号：US577023
申请日：1990-09-04
Applicant: Samuel K. Martin
Inventor： Samuel K. Martin
IPC: B60R3/02
CPC classification number: B60R3/02
Abstract: A folding step apparatus (38) is provided for vehicles having either a hinged door (26) or a sliding door (26'). The apparatus includes two parallel step supporting members (44) pivotally attached to the underside of the vehicle for adjustably supporting a step (42) or plurality of steps. A spring member (46) is used to bias the supporting members (44) and attached steps to a retracted position beneath the vehicle. A cable (64) has a first end attached to the locking end of the door and a second end attached to a front one of the supporting members (44). The cable is at least partially disposed within a hollow cord (70) which extends through portions of the vehicle frame. Opening the vehicle door causes the folding step assembly (38) to pivot about an axis perpendicular to the longitudinal horizontal axis (36) of the vehicle, thereby extending the step assembly (38) for facilitating easy boarding of the vehicle.
Abstract translation: 为具有铰接门（26）或滑动门（26'）的车辆提供折叠步进装置（38）。 该装置包括两个平行的台阶支撑构件（44），其枢转地附接到车辆的下侧，用于可调节地支撑台阶（42）或多个台阶。 弹簧构件（46）用于将支撑构件（44）和附接的台阶偏压到车辆下方的缩回位置。 电缆（64）具有附接到门的锁定端的第一端和附接到支撑构件（44）的前侧的第二端。 电缆至少部分地设置在延伸穿过车辆框架的部分的空心线（70）内。 打开车门使得折叠步骤组件（38）围绕垂直于车辆的纵向水平轴线（36）的轴线枢转，从而延伸台阶组件（38），以便于车辆的轻松登机。
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公开(公告)号：US20090317499A1
公开(公告)日：2009-12-24
申请号：US12460289
申请日：2009-07-16
Applicant: Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
Inventor： Bruno K. Kubata , Samuel K. Martin , Wilbur K. Milhous
IPC: A61K36/282 , A61K31/335 , A61P33/00
CPC classification number: A61K31/366 , A61K31/357 , A61K36/282
Abstract: The invention relates to the treatment of kintoplastid infections by administering a pharmaceutical composition containing an extract from the plant Artemisia annua. The invention also relates to isolated, semi-synthetic and synthetic artemisinins that show improved efficacy in treating kinetoplastid infections. This invention also relates to a method of treating kintoplastid infections with artelinic acid and artemisinins and where Artelinic acid is administered orally.
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公开(公告)号：US07452721B2
公开(公告)日：2008-11-18
申请号：US10990971
申请日：2004-11-18
Applicant: Samuel K. Martin
Inventor： Samuel K. Martin
CPC classification number: G01N33/56905 , C07K14/44 , G01N2469/20 , Y02A50/55
Abstract: Methods for the diagnosis of visceral, cutaneous and canine leishmaniasis in a subject suspected of being infected with the parasitic protozoa Leishmania is disclosed. Disclosed are antibody-capture enzyme-linked immunosorbent assays (ELISAs) for the detection of antibodies to Leishmania parasite soluble antigens and antigen-capture ELISAs for the detection of Leishmania parasite soluble antigens in host samples. Also disclosed are immunodiagnostic kits for the detection of Leishmania parasite circulating antigens or IgM and IgG antibodies in a sample from subject having visceral, cutaneous or canine leishmaniasis. In these methods and kits, detection may be done photometrically or visually. The methods and kits also allow the visualization of Leishmania amastigotes or promastigotes in a sample.
Abstract translation: 公开了在疑似感染寄生原虫利什曼原虫的受试者中诊断内脏，皮肤和犬利什曼病的方法。 公开了用于检测利什曼原虫寄生虫可溶性抗原的抗体的抗体捕获酶联免疫吸附测定（ELISA）和用于检测宿主样品中利什曼原虫寄生虫可溶性抗原的抗原捕获ELISA。 还公开了用于在具有内脏，皮肤或犬利什曼病的受试者的样品中检测利什曼原虫寄生虫循环抗原或IgM和IgG抗体的免疫诊断试剂盒。 在这些方法和试剂盒中，可以通过光度或视觉方式进行检测。 方法和试剂盒还允许在样品中可视化利什曼原虫或反义具。
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