-
公开(公告)号：US20090044096A1
公开(公告)日：2009-02-12
申请号：US12186682
申请日：2008-08-06
IPC分类号： G06F17/24
CPC分类号： G06F17/30976 , G06F8/51 , G06N5/02
摘要： Using natural language-like user inputs to provide statistics on a subset of data is described. In one embodiment, a user input that includes at least one word or phrase representing a rule is received. The rule includes an identification of a subset of data and a statistical expression to be performed on the subset of data. The subset of data includes at least part of the data elements of a data set. Each data element includes information on an individual or group. Instructions are provided for translating the rule into an executable format. The executable format includes a translated identification of the subset and a translated statistical expression. The subset of the data is accessed using the translated identification of the subset. The translated statistical expression is executed to obtain statistics on data elements of the subset of data. The statistics on the data elements are provided.
摘要翻译： 描述了使用自然语言的用户输入来提供数据子集的统计数据。 在一个实施例中，接收包括表示规则的至少一个单词或短语的用户输入。 该规则包括要对数据子集执行的数据子集的标识和统计表达式。 数据子集包括数据集的数据元素的至少一部分。 每个数据元素包括关于个人或组的信息。 提供了将规则翻译成可执行格式的说明。 可执行格式包括该子集的翻译标识和翻译的统计表达式。 使用子集的翻译标识来访问数据的子集。 执行翻译的统计表达式以获得关于数据子集的数据元素的统计。 提供了有关数据元素的统计信息。
-
公开(公告)号：US08700597B2
公开(公告)日：2014-04-15
申请号：US12186682
申请日：2008-08-06
CPC分类号： G06F17/30976 , G06F8/51 , G06N5/02
摘要： Using natural language-like user inputs to provide statistics on a subset of data is described. In one embodiment, a user input that includes at least one word or phrase representing a rule is received. The rule includes an identification of a subset of data and a statistical expression to be performed on the subset of data. The subset of data includes at least part of the data elements of a data set. Each data element includes information on an individual or group. Instructions are provided for translating the rule into an executable format. The executable format includes a translated identification of the subset and a translated statistical expression. The subset of the data is accessed using the translated identification of the subset. The translated statistical expression is executed to obtain statistics on data elements of the subset of data. The statistics on the data elements are provided.
摘要翻译： 描述了使用自然语言的用户输入来提供数据子集的统计数据。 在一个实施例中，接收包括表示规则的至少一个单词或短语的用户输入。 该规则包括要对数据子集执行的数据子集的标识和统计表达式。 数据子集包括数据集的数据元素的至少一部分。 每个数据元素包括关于个人或组的信息。 提供了将规则翻译成可执行格式的说明。 可执行格式包括该子集的翻译标识和翻译的统计表达式。 使用子集的翻译标识来访问数据的子集。 执行翻译的统计表达式以获得关于数据子集的数据元素的统计。 提供了有关数据元素的统计信息。
-
公开(公告)号：US08124581B2
公开(公告)日：2012-02-28
申请号：US12802371
申请日：2010-06-04
申请人： Li Dangsheng , Sharmistha Das , Herbert Samuels
发明人： Li Dangsheng , Sharmistha Das , Herbert Samuels
IPC分类号： A61K38/00
CPC分类号： A61K38/17 , C07K14/4705 , C07K2319/10 , A61K2300/00
摘要： Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer.
摘要翻译： 本文公开了这样的发现，即将NRIF3家族的转录核糖体（NRIF3和相关分子）施用于乳腺癌细胞诱导快速和深刻的凋亡（24小时内几乎100％的细胞死亡）。 将新的死亡结构域（DD1）映射到NRIF3家族所有成员共同的短30个氨基酸区域。 还发现另外两个死亡区域（DD2和DD3）有有效的乳腺癌杀伤活动。 机制研究表明，DD1诱导的细胞凋亡发生在一个新的caspase-2介导的途径，涉及线粒体膜透化，但不需要其他半胱天冬酶。 有趣的是，NRIF3相关分子的细胞毒性是细胞型特异性的，因为它们选择性地杀死乳腺癌或相关细胞，而不是其他检测不同来源的细胞，表明在乳腺癌细胞中存在可由NRIF3选择性触发的特异性死亡开关 和相关分子。 还公开了利用NRIF3相关分子和/或靶向该死亡开关以开发针对乳腺癌的新型和更多选择性治疗剂的策略。
-
公开(公告)号：US20080182794A1
公开(公告)日：2008-07-31
申请号：US11834853
申请日：2007-08-07
申请人： Li Dangsheng , Sharmistha Das , Herbert Samuels
发明人： Li Dangsheng , Sharmistha Das , Herbert Samuels
IPC分类号： A61K38/03 , A61K31/7088 , C12N15/64 , A61P35/00
CPC分类号： A61K38/17 , C07K14/4705 , C07K2319/10 , A61K2300/00
摘要： Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer.
摘要翻译： 本文公开了这样的发现，即将NRIF3家族的转录核糖体（NRIF3和相关分子）施用于乳腺癌细胞诱导快速和深刻的凋亡（24小时内几乎100％的细胞死亡）。 将新的死亡结构域（DD1）映射到NRIF3家族所有成员共同的短30个氨基酸区域。 还发现另外两个死亡区域（DD2和DD3）有有效的乳腺癌杀伤活动。 机制研究表明，DD1诱导的细胞凋亡发生在一个新的caspase-2介导的途径，涉及线粒体膜透化，但不需要其他半胱天冬酶。 有趣的是，NRIF3相关分子的细胞毒性是细胞型特异性的，因为它们选择性地杀死乳腺癌或相关细胞，而不是其他检测不同来源的细胞，表明在乳腺癌细胞中存在可由NRIF3选择性触发的特异性死亡开关 和相关分子。 还公开了利用NRIF3相关分子和/或靶向该死亡开关以开发针对乳腺癌的新型和更多选择性治疗剂的策略。
-
公开(公告)号：US20050272651A1
公开(公告)日：2005-12-08
申请号：US11068717
申请日：2005-02-23
申请人： Li Dangsheng , Sharmistha Das , Herbert Samuels
发明人： Li Dangsheng , Sharmistha Das , Herbert Samuels
IPC分类号： A61K38/17 , A61K38/18 , C07K14/47 , C07K14/475
CPC分类号： A61K38/17 , C07K14/4705 , C07K2319/10 , A61K2300/00
摘要： Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer.
摘要翻译： 本文公开了这样的发现，即将NRIF3家族的转录核糖体（NRIF3和相关分子）施用于乳腺癌细胞诱导快速和深刻的凋亡（24小时内几乎100％的细胞死亡）。 将新的死亡结构域（DD1）映射到NRIF3家族所有成员共同的短30个氨基酸区域。 还发现另外两个死亡区域（DD2和DD3）有有效的乳腺癌杀伤活动。 机制研究表明，DD1诱导的细胞凋亡发生在一个新的caspase-2介导的途径，涉及线粒体膜透化，但不需要其他半胱天冬酶。 有趣的是，NRIF3相关分子的细胞毒性是细胞型特异性的，因为它们选择性地杀死乳腺癌或相关细胞，而不是其他检测不同来源的细胞，表明在乳腺癌细胞中存在可由NRIF3选择性触发的特异性死亡开关 和相关分子。 还公开了利用NRIF3相关分子和/或靶向该死亡开关以开发针对乳腺癌的新型和更多选择性治疗剂的策略。
-
公开(公告)号：US06950511B2
公开(公告)日：2005-09-27
申请号：US10713940
申请日：2003-11-13
申请人： Sharmistha Das , Matthew McShea
发明人： Sharmistha Das , Matthew McShea
CPC分类号： H04Q1/46
摘要： A plurality of Goertzel filters whose operating frequencies are distributed across the voice baseband are used to detect voice and control tones in a signal. Filters operating at frequencies of control tones and detecting that most of the signal energy occurs at those frequencies indicates presence of the control tones. At least three of the filters detecting that about 10% to 20% of the signal energy occurs at each of their operating frequencies indicate presence of voice. The total energy detected in the signal being below a noise threshold indicates presence of noise or silence.
摘要翻译： 使用多个操作频率分布在语音基带上的Goertzel滤波器来检测信号中的语音和控制音调。 在控制频率的频率下工作的滤波器并且检测到在这些频率处发生大部分信号能量的滤波器指示控制音调的存在。 检测到在其工作频率的每一个处发生大约10％至20％的信号能量的滤波器中的至少三个表示声音的存在。 在信号中检测到的总能量低于噪声阈值表明存在噪声或沉默。
-
公开(公告)号：US20100317594A1
公开(公告)日：2010-12-16
申请号：US12802371
申请日：2010-06-04
申请人： Li Dangsheng , Sharmistha Das , Herbert Samuels
发明人： Li Dangsheng , Sharmistha Das , Herbert Samuels
CPC分类号： A61K38/17 , C07K14/4705 , C07K2319/10 , A61K2300/00
摘要： Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer.
摘要翻译： 本文公开了这样的发现，即将NRIF3家族的转录核糖体（NRIF3和相关分子）施用于乳腺癌细胞诱导快速和深刻的凋亡（24小时内几乎100％的细胞死亡）。 将新的死亡结构域（DD1）映射到NRIF3家族所有成员共同的短30个氨基酸区域。 还发现另外两个死亡区域（DD2和DD3）有有效的乳腺癌杀伤活动。 机制研究表明，DD1诱导的细胞凋亡发生在一个新的caspase-2介导的途径，涉及线粒体膜透化，但不需要其他半胱天冬酶。 有趣的是，NRIF3相关分子的细胞毒性是细胞型特异性的，因为它们选择性地杀死乳腺癌或相关细胞，而不是其他检测不同来源的细胞，表明在乳腺癌细胞中存在可由NRIF3选择性触发的特异性死亡开关 和相关分子。 还公开了利用NRIF3相关分子和/或靶向该死亡开关以开发针对乳腺癌的新型和更多选择性治疗剂的策略。
-
公开(公告)号：US07772202B2
公开(公告)日：2010-08-10
申请号：US11834853
申请日：2007-08-07
申请人： Li Dangsheng , Sharmistha Das , Herbert Samuels
发明人： Li Dangsheng , Sharmistha Das , Herbert Samuels
CPC分类号： A61K38/17 , C07K14/4705 , C07K2319/10 , A61K2300/00
摘要： Disclosed herein is the discovery that administration of the NRIF3 family of transcriptional coregulators (NRIF3 and related molecules) to breast cancer cells induce rapid and profound apoptosis (nearly 100% cell death within 24 h). A novel death domain (DD1) was mapped to a short 30 amino acid region common to all members of the NRIF3 family. Two other death domains (DD2 and DD3) were also found to have effective breast cancer killing activities. Mechanistic studies showed that DD1-induced apoptosis occurred through a novel caspase-2 mediated pathway that involved mitochondria membrane permeabilization but did not require other caspases. Interestingly, cytotoxicity of NRIF3 related molecules was cell-type specific, as they selectively killed breast cancer or related cells but not other examined cells of different origins, suggesting the presence in breast cancer cells of a specific death switch that can be selectively triggered by NRIF3 and related molecules. Also disclosed are strategies utilizing NRIF3 related molecules and/or targeting this death switch for the development of novel and more selective therapeutics against breast cancer.
-
公开(公告)号：US20050105716A1
公开(公告)日：2005-05-19
申请号：US10713940
申请日：2003-11-13
申请人： Sharmistha Das , Matthew McShea
发明人： Sharmistha Das , Matthew McShea
CPC分类号： H04Q1/46
摘要： A plurality of Goertzel filters whose operating frequencies are distributed across the voice baseband are used to detect voice and control tones in a signal. Filters operating at frequencies of control tones and detecting that most of the signal energy occurs at those frequencies indicates presence of the control tones. At least three of the filters detecting that about 10% to 20% of the signal energy occurs at each of their operating frequencies indicate presence of voice. The total energy detected in the signal being below a noise threshold indicates presence of noise or silence.
-
-
-
-
-
-
-
-
搜索结果
9 条记录 (耗时 0.029 秒)
