公开(公告)号：US09642802B2

公开(公告)日：2017-05-09

申请号：US13809469

申请日：2011-07-08

申请人： Sander Langereis ,  Holger Gruell ,  Mariska De Smet ,  Erica Maria Gerarda Aussems-Custers ,  Johan Lub

发明人： Sander Langereis ,  Holger Gruell ,  Mariska De Smet ,  Erica Maria Gerarda Aussems-Custers ,  Johan Lub

IPC分类号： A61K9/127 ,  A61K41/00 ,  A61K31/704 ,  A61K49/10 ,  A61K49/18

CPC分类号： A61K9/127 ,  A61K31/704 ,  A61K41/0028 ,  A61K49/106 ,  A61K49/1812

摘要： Disclosed are carriers for drugs and/or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long/short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.

公开(公告)号：US20130108551A1

公开(公告)日：2013-05-02

申请号：US13809469

申请日：2011-07-08

申请人： Sander Langereis ,  Holger Gruell ,  Mariska De Smet ,  Erica Maria Gerarda Aussems-Custers ,  Johan Lub

发明人： Sander Langereis ,  Holger Gruell ,  Mariska De Smet ,  Erica Maria Gerarda Aussems-Custers ,  Johan Lub

IPC分类号： A61K9/127

CPC分类号： A61K9/127 ,  A61K31/704 ,  A61K41/0028 ,  A61K49/106 ,  A61K49/1812

摘要： Disclosed are carriers for drugs and/or MR imaging agents having a lipid bilayer shell comprising a phospholipid having two terminal alkyl chains, one being a short chain having a chain length of at most seven carbon atoms, the other being a long chain having a chain length of at least fifteen carbon atoms. The mixed long/short chain phospholipids serve to tune the release properties of the carrier. Preferred phospholipids are phosphatidylcholines.

摘要翻译： 公开了具有脂质双层壳的药物和/或MR成像剂的载体，其包含具有两个末端烷基链的磷脂，一个是具有至多7个碳原子的链长的短链，另一个是具有链的长链 长度至少十五个碳原子。 混合的长/短链磷脂用于调节载体的释放性质。 优选的磷脂是磷脂酰胆碱。