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1.发明授权公开(公告)号：US09273305B1
公开(公告)日：2016-03-01
申请号：US13869799
申请日：2013-04-24
Applicant: Sandia Corporation , STC.UNM
Inventor： Bryan J. Kaehr , C. Jeffrey Brinker , Jason L. Townson
IPC: C12N11/14
CPC classification number: G01N1/2806 , C08K3/36 , C12N11/14 , G01N1/2853
Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
Abstract translation: 本发明涉及使用硅酸将生物材料（包括细胞结构）转化为无机材料以提供具有稳定结构和功能的生物复合材料（纳米材料）。 在本发明中，已经发现了稳定生物材料的结构和功能的手段，包括细胞，生物分子，肽，蛋白质（特别是酶），脂质，脂质囊泡，多糖，细胞骨架细丝，组织和器官与硅 酸，使得这些材料可以用作生物复合材料。 在许多情况下，这些材料保留其原始生物活性，并且可以在恶劣条件下使用，否则会破坏生物材料的完整性。 在某些情况下，这些生物材料可能长时间保持稳定，并在储存后重构，以将生物材料返回其原始形式。 此外，通过暴露整个细胞以形成CSCs，CSC可以起到提供独特的系统来研究否则不可用的酶或级联的酶。
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Patent Agency Ranking
2.发明申请公开(公告)号：US20160208238A1
公开(公告)日：2016-07-21
申请号：US14996048
申请日：2016-01-14
Applicant: Sandia Corporation , STC.UNM
Inventor： Bryan J. Kaehr , C. Jeffrey Brinker , Jason L. Townson
IPC: C12N11/14
CPC classification number: G01N1/2806 , C08K3/36 , C12N11/14 , G01N1/2853
Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
Abstract translation: 本发明涉及使用硅酸将生物材料（包括细胞结构）转化为无机材料以提供具有稳定结构和功能的生物复合材料（纳米材料）。 在本发明中，已经发现了稳定生物材料的结构和功能的手段，包括细胞，生物分子，肽，蛋白质（特别是酶），脂质，脂质囊泡，多糖，细胞骨架细丝，组织和器官与硅 酸，使得这些材料可以用作生物复合材料。 在许多情况下，这些材料保留其原始生物活性，并且可以在恶劣条件下使用，否则会破坏生物材料的完整性。 在某些情况下，这些生物材料可能长时间保持稳定，并在储存后重构，以将生物材料返回其原始形式。 此外，通过暴露整个细胞以形成CSCs，CSC可以起到提供独特的系统来研究否则不可用的酶或级联的酶。
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公开(公告)号：US09989447B1
公开(公告)日：2018-06-05
申请号：US14795366
申请日：2015-07-09
Applicant: Sandia Corporation , STC.UNM
Inventor： Bryan J. Kaehr , Kristin Meyer , Jason L. Townson
CPC classification number: G01N1/2806 , C08K3/36 , C12N11/14 , G01N1/2853
Abstract: The present invention relates to methods of transforming organic matter into organic-inorganic composites, inorganic replicas, or conductive replicas. Organic matter, such as biological cells and tissue and organs, can be converted into such composites and replicas using the methods described herein. In particular, such methods transform organic matter (into inorganic, organic-inorganic, or conductive constructs), while simultaneously preserving microscopic and/or macroscopic structural detail.
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公开(公告)号：US09970000B2
公开(公告)日：2018-05-15
申请号：US14996048
申请日：2016-01-14
Inventor： Bryan J. Kaehr , C. Jeffrey Brinker , Jason L. Townson
CPC classification number: G01N1/2806 , C08K3/36 , C12N11/14 , G01N1/2853
Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
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公开(公告)号：US20180299357A1
公开(公告)日：2018-10-18
申请号：US15950979
申请日：2018-04-11
Inventor： Bryan J. Kaehr , C. Jeffrey Brinker , Jason L. Townson
Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
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公开(公告)号：US10605705B2
公开(公告)日：2020-03-31
申请号：US15950979
申请日：2018-04-11
Inventor： Bryan J. Kaehr , C. Jeffrey Brinker , Jason L. Townson
Abstract: The present invention is directed to the use of silicic acid to transform biological materials, including cellular architecture into inorganic materials to provide biocomposites (nanomaterials) with stabilized structure and function. In the present invention, there has been discovered a means to stabilize the structure and function of biological materials, including cells, biomolecules, peptides, proteins (especially including enzymes), lipids, lipid vesicles, polysaccharides, cytoskeletal filaments, tissue and organs with silicic acid such that these materials may be used as biocomposites. In many instances, these materials retain their original biological activity and may be used in harsh conditions which would otherwise destroy the integrity of the biological material. In certain instances, these biomaterials may be storage stable for long periods of time and reconstituted after storage to return the biological material back to its original form. In addition, by exposing an entire cell to form CSCs, the CSCs may function to provide a unique system to study enzymes or a cascade of enzymes which are otherwise unavailable.
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