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公开(公告)号：US20090258435A1
公开(公告)日：2009-10-15
申请号：US12103245
申请日：2008-04-15
IPC分类号： G01N33/566 , G01N33/536
CPC分类号： G01N33/532 , G01N33/54393 , G01N33/566
摘要： Methods are disclosed for designing an antibody reagent for use in an assay for the detection of an analyte to obtain an optimum assay sensitivity and/or dynamic range. The antibody reagent is a conjugate of a small molecule attached by a spacer group to an antibody for the analyte. The method comprises controlling, in the preparation of the conjugate, reaction parameters comprising the hydrophobicity or hydrophilicity of the spacer group, the length of the spacer group, the number of molecules of the small molecule attached to the antibody and the point of attachment of the small molecule to the antibody to obtain an optimum assay sensitivity and/or dynamic range. In some embodiments the method comprises preparing two or more conjugates by selecting a set of parameters for each conjugate wherein the set of parameters is different for each conjugate, conducting an assay for the analyte employing each conjugate and selecting for use in the assay the conjugate that provides the optimum assay sensitivity and/or dynamic range.
摘要翻译： 公开了设计用于分析物检测以获得最佳测定灵敏度和/或动态范围的测定中的抗体试剂的方法。 抗体试剂是通过间隔基团与分析物的抗体连接的小分子的缀合物。 该方法包括在共轭物的制备中控制包括间隔基团的疏水性或亲水性，间隔基团的长度，与抗体连接的小分子的分子数目和 小分子到抗体以获得最佳测定灵敏度和/或动态范围。 在一些实施方案中，该方法包括通过为每个缀合物选择一组参数来制备两种或多种缀合物，其中该组参数对于每个缀合物是不同的，使用每个缀合物进行分析物的测定，并选择用于测定缀合物 提供最佳测定灵敏度和/或动态范围。
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公开(公告)号：US20090199326A1
公开(公告)日：2009-08-13
申请号：US12366361
申请日：2009-02-05
申请人： Bill E. Brauner , James E. Duffy , Eivind Clausen
发明人： Bill E. Brauner , James E. Duffy , Eivind Clausen
摘要： A retractable earplug assembly is provided that is configured to retrofit to a hardhat that includes a protective housing removably mountable to the hardhat. The earplug assembly further includes a guide base slideably cooperating with a guide portion of the housing for movement thereof along a fixed path. The earplug assembly includes an elongated flexible tether having a distal portion thereof mounted to an earplug device, and a proximal portion thereof mounted to the guide base. When the guide base is selectively moved along the fixed path, the tether and the earplug device move between a retracted condition and an extended condition, enabling usable access to the earplug device.
摘要翻译： 提供可伸缩耳塞组件，其被配置成改装为包括可移除地安装到硬帽的保护壳体的硬帽。 耳塞组件还包括可滑动地与壳体的引导部分配合的引导基座，用于沿固定路径移动。 耳塞组件包括细长的柔性系绳，其具有其远端部分安装到耳塞装置，并且其近端部分安装到导向基座。 当导向台选择性地沿着固定路径移动时，系绳和耳塞装置在缩回状态和延伸状态之间移动，使得能够接近耳塞装置。
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