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公开(公告)号：US08367054B2
公开(公告)日：2013-02-05
申请号：US12515975
申请日：2007-11-16
申请人： Sanjay Bandyopadhyay , Venkatesan Natarajan , Sanjeev Kumar Mendiratta , Pankaj Ramanbhai Patel
发明人： Sanjay Bandyopadhyay , Venkatesan Natarajan , Sanjeev Kumar Mendiratta , Pankaj Ramanbhai Patel
CPC分类号： A61K9/19 , A61K9/0019 , A61K38/212 , A61K47/12 , A61K47/183 , A61K47/26 , A61K47/60
摘要： Lyophilized and stabilized formulations of PEG-Interferon alpha conjugates and the process for their preparation that reduces lyophilization cycle time and are more cost competitive.
摘要翻译： 冻干和稳定的PEG-干扰素α缀合物的制剂及其制备方法，其减少冻干周期时间并且具有更高的成本竞争力。
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公开(公告)号：US20130330808A1
公开(公告)日：2013-12-12
申请号：US13885002
申请日：2011-11-15
IPC分类号： C12N9/72
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： The present invention provides process of purification of tissue plasminogen activator (tPA) from a crude mixture or a partially purified mixture containing tPA protein and impurities by using hydrophobic interaction column chromatography, optionally in combination with ion exchange column chromatography.
摘要翻译： 本发明提供了通过使用疏水相互作用柱层析，任选与离子交换柱层析组合，从粗混合物或含有tPA蛋白质和杂质的部分纯化的混合物中纯化组织纤溶酶原激活物（tPA）的方法。
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公开(公告)号：US09175281B2
公开(公告)日：2015-11-03
申请号：US13885002
申请日：2011-11-15
IPC分类号： C12N9/72
CPC分类号： C12N9/6459 , C12Y304/21069
摘要： The present invention provides process of purification of tissue plasminogen activator (tPA) from a crude mixture or a partially purified mixture containing tPA protein and impurities by using hydrophobic interaction column chromatography, optionally in combination with ion exchange column chromatography.
摘要翻译： 本发明提供了通过使用疏水相互作用柱层析，任选与离子交换柱层析组合，从粗混合物或含有tPA蛋白质和杂质的部分纯化的混合物中纯化组织纤溶酶原激活物（tPA）的方法。
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公开(公告)号：US20120142891A1
公开(公告)日：2012-06-07
申请号：US12679346
申请日：2008-09-22
申请人： Sanjeev Kumar Mendirette , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
发明人： Sanjeev Kumar Mendirette , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
CPC分类号： C12N15/62 , C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
摘要： The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
摘要翻译： 本发明公开了通过使用G-CSF作为这些细胞中高水平表达的新型融合配偶体从细菌细胞中产生所需重组肽的改进方法。 本发明还提供了包含融合蛋白的表达系统，其中G-CSF通过酶或化学切割位点可操作地连接到目的肽，其可用于从融合配偶体与所述肽分离。
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5.发明授权Process for the expression of peptides of interest using GCSF as a fusion partner 有权使用GCSF作为融合配偶体表达目的肽的方法公开(公告)号：US08507221B2
公开(公告)日：2013-08-13
申请号：US12679346
申请日：2008-09-22
申请人： Sanjeev Kumar Mendiretta , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
发明人： Sanjeev Kumar Mendiretta , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
IPC分类号： C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
CPC分类号： C12N15/62 , C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
摘要： The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
摘要翻译： 本发明公开了通过使用G-CSF作为这些细胞中高水平表达的新型融合配偶体从细菌细胞中产生所需重组肽的改进方法。 本发明还提供了包含融合蛋白的表达系统，其中G-CSF通过酶或化学切割位点可操作地连接到目的肽，其可用于从融合配偶体与所述肽分离。
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