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公开(公告)号：US20120142891A1
公开(公告)日：2012-06-07
申请号：US12679346
申请日：2008-09-22
申请人： Sanjeev Kumar Mendirette , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
发明人： Sanjeev Kumar Mendirette , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
CPC分类号： C12N15/62 , C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
摘要： The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
摘要翻译： 本发明公开了通过使用G-CSF作为这些细胞中高水平表达的新型融合配偶体从细菌细胞中产生所需重组肽的改进方法。 本发明还提供了包含融合蛋白的表达系统，其中G-CSF通过酶或化学切割位点可操作地连接到目的肽，其可用于从融合配偶体与所述肽分离。
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2.发明授权Process for the expression of peptides of interest using GCSF as a fusion partner 有权使用GCSF作为融合配偶体表达目的肽的方法公开(公告)号：US08507221B2
公开(公告)日：2013-08-13
申请号：US12679346
申请日：2008-09-22
申请人： Sanjeev Kumar Mendiretta , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
发明人： Sanjeev Kumar Mendiretta , Pankaj R. Patel , Sanjay Bandyopadhyay , Vibhor Saraswat , Arun Kumar Singh
IPC分类号： C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
CPC分类号： C12N15/62 , C07K14/535 , C07K14/62 , C07K14/635 , C12P21/02
摘要： The present invention discloses an improved process for the production of desired recombinant peptides from bacterial cells by using G-CSF as a novel fusion partner for their high level expression in these cells. The invention further provides an expression system comprising the fusion protein wherein the G-CSF is operatively linked to the peptide of interest via an enzymatic or chemical cleavage site which can be used to separate the fusion partner from the said peptide.
摘要翻译： 本发明公开了通过使用G-CSF作为这些细胞中高水平表达的新型融合配偶体从细菌细胞中产生所需重组肽的改进方法。 本发明还提供了包含融合蛋白的表达系统，其中G-CSF通过酶或化学切割位点可操作地连接到目的肽，其可用于从融合配偶体与所述肽分离。
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公开(公告)号：US08021862B2
公开(公告)日：2011-09-20
申请号：US12280496
申请日：2007-03-05
CPC分类号： C07K14/535 , C12N1/20
摘要： The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
摘要翻译： 本发明公开了一种通过在生产阶段通过高盐诱导的质粒稳定性增加而以高产率生产G-CSF的改进方法。
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公开(公告)号：US08492120B2
公开(公告)日：2013-07-23
申请号：US12952277
申请日：2010-11-23
IPC分类号： C12N1/20 , C07K14/535
CPC分类号： C07K14/535 , C12N1/20
摘要： The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
摘要翻译： 本发明公开了一种通过在生产阶段通过高盐诱导的质粒稳定性增加而以高产率生产G-CSF的改进方法。
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公开(公告)号：US20110070611A1
公开(公告)日：2011-03-24
申请号：US12952277
申请日：2010-11-23
IPC分类号： C12P21/00
CPC分类号： C07K14/535 , C12N1/20
摘要： The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
摘要翻译： 本发明公开了一种通过在生产阶段通过高盐诱导的质粒稳定性增加而以高产率生产G-CSF的改进方法。
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公开(公告)号：US20090305354A1
公开(公告)日：2009-12-10
申请号：US12280496
申请日：2007-03-07
IPC分类号： C12P21/02
CPC分类号： C07K14/535 , C12N1/20
摘要： The present invention discloses an improved process for the production of G-CSF in high yield via a high salt-induced increase in plasmid stability during the production phase.
摘要翻译： 本发明公开了一种通过在生产阶段通过高盐诱导的质粒稳定性增加而以高产率生产G-CSF的改进方法。
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公开(公告)号：US20090215121A1
公开(公告)日：2009-08-27
申请号：US11793114
申请日：2005-12-19
IPC分类号： C12P21/06
CPC分类号： C07K14/565
摘要： The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation.
摘要翻译： 本发明涉及通过发酵提高产率的用于生产干扰素-β的新方法。
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公开(公告)号：US07923220B2
公开(公告)日：2011-04-12
申请号：US11793114
申请日：2005-12-19
IPC分类号： C12P21/00
CPC分类号： C07K14/565
摘要： The present invention relates to a novel process for the production of interferon-beta in improved yields by fermentation.
摘要翻译： 本发明涉及通过发酵提高产率的用于生产干扰素-β的新方法。
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