公开(公告)号：US20110136889A1

公开(公告)日：2011-06-09

申请号：US11910606

申请日：2006-04-10

申请人： Sanjay Bhanot ,  Brett P. Monia ,  John Geisler ,  Robert Mckay ,  Kenneth W. Dobie

发明人： Sanjay Bhanot ,  Brett P. Monia ,  John Geisler ,  Robert Mckay ,  Kenneth W. Dobie

IPC分类号： A61K31/7088 ,  C07H21/00 ,  C07H21/04 ,  A61P3/04 ,  A61P3/10 ,  A61P3/00 ,  A61P1/16 ,  A61P9/00

CPC分类号： C12N15/1137 ,  A61K31/202 ,  C12N2310/11 ,  C12N2310/315 ,  C12N2310/321 ,  C12N2310/3341 ,  C12N2310/341 ,  C12N2310/346 ,  C12N2310/3521

摘要： Disclosed herein are compounds, compositions and methods for modulating the expression of ACC1 or ACC2 or both in a cell, tissue or animal. Also provided are uses of disclosed compounds and compositions in the manufacture of a medicament for treatment of diseases and disorders.

摘要翻译： 本文公开了用于在细胞，组织或动物中调节ACC1或ACC2或两者的表达的化合物，组合物和方法。 还提供了所公开的化合物和组合物在制备用于治疗疾病和病症的药物中的用途。

公开(公告)号：US20080079238A1

公开(公告)日：2008-04-03

申请号：US11903496

申请日：2007-09-21

申请人： John Geisler ,  Tim Dehate

发明人： John Geisler ,  Tim Dehate

IPC分类号： A63C5/14

CPC分类号： A63C5/061

摘要： A mechanically attached snowboard with a plurality of snow removal elements attached to its top surface that allows a snowboarder to remove compact snow and ice from the bottom on his or her boot before placing the boot into the binding or act as a temporary traction device for the detached rear boot. Each removal element includes an adapter adhesively attached and particularly embedded into the snowboard. Each adapter includes a threaded bore that is designed to receive a threaded bolt attached to a conical cap. During use, the conical cap extends above the top surface of the snowboard and scrapes away snow and ice located in the treads formed on the bottom of the snowboarder's boot. In the preferred embodiment, a plurality of adapters and caps are aligned on the top surface of the snowboard so that the entire lower surface of the boot can be easily cleaned by stomping or swiping the bottom surface of the boot thereover. The caps also act as a temporary traction device for the rear boot when exiting a chairlift.

摘要翻译： 一种机械连接的滑雪板，具有附接到其顶表面的多个除雪元件，其允许滑雪板在将靴子放置在捆绑中之前从底部移除紧固的雪和冰，或者用作临时牵引装置 分离的后靴。 每个移除元件包括粘合地附接并特别嵌入到滑雪板中的适配器。 每个适配器包括螺纹孔，其被设计成接收连接到锥形盖的螺纹螺栓。 在使用过程中，锥形帽在滑雪板的上表面上方延伸，并刮掉位于滑雪板靴底部形成的胎面中的雪和冰。 在优选实施例中，多个适配器和盖子对准在滑雪板的顶表面上，使得靴子的整个下表面可以通过踩踏或滑动其上的靴子的底表面来容易地清洁。 当离开升降椅时，盖子也可以用作后靴的临时牵引装置。