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公开(公告)号：US09062046B2
公开(公告)日：2015-06-23
申请号：US13810431
申请日：2011-07-15
申请人： Sanjay Kumar , Rajiv Sharma , Robert Zahler , Bichismita Sahu , Veena R. Agarwal , Nishigandha Naik
发明人： Sanjay Kumar , Rajiv Sharma , Robert Zahler , Bichismita Sahu , Veena R. Agarwal , Nishigandha Naik
IPC分类号： A61K31/43 , C07D471/00 , C07D491/00 , C07D498/00 , C07D513/00 , C07D515/00 , C07D471/04 , A61K31/4745
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/411
摘要： The present invention relates to substituted imidazo[4,5-c]quinoline derivatives, the compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of formula (I), and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammatory diseases and angiogenesis related disorders.
摘要翻译： 本发明涉及取代的咪唑并[4,5-c]喹啉衍生物，式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如说明书中所定义，其制备方法 包含式（I）化合物的药物组合物及其在治疗由一种或多种激酶，特别是增殖性疾病或病症如癌症介导的疾病或病症中的用途。 这些化合物也可用于治疗炎性疾病和血管发生相关疾病。
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公开(公告)号：US20130116248A1
公开(公告)日：2013-05-09
申请号：US13810431
申请日：2011-07-15
申请人： Sanjay Kumar , Rajiv Sharma , Robert Zahler , Bichismita Sahu , Veena R. Agarwal , Nishigandha Naik
发明人： Sanjay Kumar , Rajiv Sharma , Robert Zahler , Bichismita Sahu , Veena R. Agarwal , Nishigandha Naik
IPC分类号： C07D471/04
CPC分类号： C07D471/04 , A61K31/4745 , Y02A50/411
摘要： The present invention relates to substituted imidazo[4,5-c]quinoline derivatives, the compounds of formula (I), wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, processes for their preparation, pharmaceutical compositions comprising compounds of formula (I), and their use in the treatment of diseases or disorders mediated by one or more kinases, particularly proliferative diseases or disorders such as cancer. These compounds can also be used in the treatment of inflammatory diseases and angiogenesis related disorders.
摘要翻译： 本发明涉及取代的咪唑并[4,5-c]喹啉衍生物，式（I）化合物，其中R 1，R 2，R 3，R 4，R 5，R 6和R 7如说明书中所定义，其制备方法 包含式（I）化合物的药物组合物及其在治疗由一种或多种激酶，特别是增殖性疾病或病症如癌症介导的疾病或病症中的用途。 这些化合物也可用于治疗炎性疾病和血管发生相关疾病。
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3.发明授权公开(公告)号：US09193758B2
公开(公告)日：2015-11-24
申请号：US14110689
申请日：2012-04-06
IPC分类号： C07H15/00 , C07H21/00 , C07K1/08 , A61K47/48 , C07D239/47 , C07D239/54 , C07D473/18 , C07D473/34 , C07K14/00
CPC分类号： C07K14/003 , A61K47/60 , C07C229/12 , C07C271/20 , C07D239/47 , C07D239/54 , C07D473/18 , C07D473/34 , C07K1/04 , C07K1/08
摘要： The present invention relates to γ-PNA monomers according to Formula I where substituent groups R1, R2, R3, R4, R5, R6, B and P are defined as set forth in the specification. The invention also provides methodology for synthesizing compounds according to Formula I and methodology for synthesizing PNA oligomers that incorporate one or more Formula I monomers.
摘要翻译： 本发明涉及式I中的取代基R1，R2，R3，R4，R5，R6，B和P定义如说明书中所述的式I的γ-PNA单体。 本发明还提供了合成根据式I的化合物和合成含有一种或多种式I单体的PNA低聚物的方法。
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4.发明申请CONFORMATIONALLY-PREORGANIZED, MINIPEG-CONTAINING GAMMA-PEPTIDE NUCLEIC ACIDS 有权具有前瞻性，含MINIPEG的GAMMA-PEPTIDE NUCLEIC ACIDS公开(公告)号：US20140128570A1
公开(公告)日：2014-05-08
申请号：US14110689
申请日：2012-04-06
IPC分类号： C07D239/47 , C07D473/18 , C07D473/34 , C07D239/54 , C07K1/08
CPC分类号： C07K14/003 , A61K47/60 , C07C229/12 , C07C271/20 , C07D239/47 , C07D239/54 , C07D473/18 , C07D473/34 , C07K1/04 , C07K1/08
摘要： The present invention relates to γ-PNA monomers according to Formula I where substituent groups R1, R2, R3, R4, R5, R6, B and P are defined as set forth in the specification. The invention also provides methodology for synthesizing compounds according to Formula I and methodology for synthesizing PNA oligomers that incorporate one or more Formula I monomers.
摘要翻译： 本发明涉及式I中的取代基R1，R2，R3，R4，R5，R6，B和P定义如说明书中所述的式I的γ-PNA单体。 本发明还提供了合成根据式I的化合物和合成含有一种或多种式I单体的PNA低聚物的方法。
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