公开(公告)号：US20050119493A1

公开(公告)日：2005-06-02

申请号：US10488411

申请日：2001-08-31

申请人： Sanjay Suri ,  J. Singh ,  S. Sarin ,  R. Bansal

发明人： Sanjay Suri ,  J. Singh ,  S. Sarin ,  R. Bansal

IPC分类号： C07D207/34 ,  C07D207/40 ,  C07D207/416 ,  C07D409/06 ,  C07D27/333

CPC分类号： C07D207/416 ,  C07D207/34 ,  C07D405/06 ,  C07D409/06

摘要： Improved process for the preparation of amorphous atorvastatin calcium salt (2:1) comprises hydrolyzing the lactone form of atorvastatin of formula of FIG. 1 with aqueous alkali or alkaline earth metal base, extracting with organic solvent the reaction mixture and adding the same to an anti-solvent to precipitate the product and finally filtering the product to afford amorphous atorvastatin calcium (2:1). The process also comprises the preparation of amorphous atorvastatin calcium salt (2:1) from its crystalline form.

摘要翻译： 用于制备无定形阿托伐他汀钙盐（2:1）的改进方法包括水解式（I）的阿托伐他汀的内酯形式。 1，用碱金属或碱土金属碱处理，用有机溶剂萃取反应混合物，并加入到反溶剂中沉淀产物，最后过滤产物，得到无定形阿托伐他汀钙（2:1）。 该方法还包括从其结晶形式制备无定形阿托伐他汀钙盐（2:1）。

公开(公告)号：US20060100435A1

公开(公告)日：2006-05-11

申请号：US10529008

申请日：2002-09-24

申请人： Sanjay Suri ,  Jujhar Singh ,  Shawkat Naim

发明人： Sanjay Suri ,  Jujhar Singh ,  Shawkat Naim

IPC分类号： C07D221/22

CPC分类号： C07D401/04

摘要： An improved process for the production of Desloratadine is described wherein Loratadine is reacted with neat alcohol in presence of inorganic base, followed by isolating Desloratadine on addition of excess water in crystalline form.

摘要翻译： 描述了一种用于制备地氯雷他定的改进方法，其中氯雷他定在无机碱存在下与纯醇反应，然后在加入过量水的结晶形式下分离去氯雷他定。

公开(公告)号：US08290838B1

公开(公告)日：2012-10-16

申请号：US11694613

申请日：2007-03-30

申请人： Aman Thakur ,  Jeffrey A. Hughes ,  Sanjay Suri

发明人： Aman Thakur ,  Jeffrey A. Hughes ,  Sanjay Suri

IPC分类号： G06Q40/00

CPC分类号： G06Q40/02

摘要： A system and method for preventing fraud in an online transaction is shown. Requests for financial transactions between on-line account holders are detected as well as relationships between the accounts. A fraud value related to a likelihood that a fraud is occurring in the transactions is determined based on the relationship. An indication of a likelihood of fraud is provided if the fraud value exceeds a predetermined amount. Thus the transaction is terminated and the appropriate parties are automatically notified.

摘要翻译： 示出了用于防止在线交易中的欺诈的系统和方法。 检测到在线账户持有者之间的金融交易请求以及账户之间的关系。 基于关系确定与交易中发生欺诈的可能性相关的欺诈价值。 如果欺诈值超过预定量，则提供欺诈可能性的指示。 因此，交易被终止，并且相应方被自动通知。

公开(公告)号：US20060122403A1

公开(公告)日：2006-06-08

申请号：US10520020

申请日：2002-09-03

申请人： Sanjay Suri ,  Jujhar Singh ,  Singh Grewal ,  Baldev Raj

发明人： Sanjay Suri ,  Jujhar Singh ,  Singh Grewal ,  Baldev Raj

IPC分类号： C07D207/34

CPC分类号： C07D405/06 ,  C07D207/34

摘要： Atorvastatin calcium Form VI Or hydrates thereof, characterized by its X-ray powder diffraction and/or solid state NMR is described, as well as methods for the preparation of the same.

摘要翻译： 阿托伐他汀钙形式VI或其水合物，其特征在于其X射线粉末衍射和/或固体NMR，以及其制备方法。

公开(公告)号：US08450491B2

公开(公告)日：2013-05-28

申请号：US10576971

申请日：2003-06-06

申请人： Sanjay Suri ,  Jujhar Singh ,  Gurdeep Singh Sarin ,  Madan Pal Tanwar ,  Manu Mahendru

发明人： Sanjay Suri ,  Jujhar Singh ,  Gurdeep Singh Sarin ,  Madan Pal Tanwar ,  Manu Mahendru

IPC分类号： C07D215/04 ,  A61K31/47

CPC分类号： C07D215/18

摘要： A method for the preparation of montelukast acid sodium salt thereof in amorphous form has been described. The method comprises of following steps: (a) generating the dilithium dianion of 1-(mercaptomethyl)cyclopropane acetic acid, by reacting with alkyl lithium, (b) coupling the said dianion with wet mesylate to get montelukast acid in crude form, (c) obtaining DCHA salt in crude form by adding dicyclohexylamine (DCHA) to crude acid obtained in the above step (b), (d) purifying and converting the said DCHA salt in crude form, to montelukast acid in pure form, and (e) reacting the pure montelukast acid in a polar protic solvent with a source of sodium ion followed by evaporating the solvent and triturating of the residue with non-polar water immiscible solvent.

摘要翻译： 已经描述了制备无定形形式的孟鲁司他酸钠盐的方法。 该方法包括以下步骤：（a）通过与烷基锂反应生成1-（巯基甲基）环丙烷乙酸的二锂二阴离子，（b）将所述二价阴离子与湿甲磺酸酯偶联得到粗制形式的孟鲁司特酸，（c 通过向上述步骤（b）中获得的粗酸加入二环己基胺（DCHA），（d）以粗制形式将所述DCHA盐纯化并转化成纯形式的孟鲁司特酸，得到粗制形式的DCHA盐，和（e） 使极性质子溶剂中的纯孟鲁司特酸与钠离子源反应，然后蒸发溶剂并用非极性水不混溶溶剂研磨残余物。

公开(公告)号：US07563911B2

公开(公告)日：2009-07-21

申请号：US10488411

申请日：2001-08-31

申请人： Sanjay Suri ,  Jujhar Singh ,  Gurdeep Singh Sarin ,  Baldev Raj Bansal

发明人： Sanjay Suri ,  Jujhar Singh ,  Gurdeep Singh Sarin ,  Baldev Raj Bansal

IPC分类号： C07D207/30

CPC分类号： C07D207/416 ,  C07D207/34 ,  C07D405/06 ,  C07D409/06

摘要： Improved process for the preparation of amorphous atorvastatin calcium salt (2:1) comprises hydrolyzing the lactone form of atorvastatin of formula of FIG. 1 with aqueous alkali or alkaline earth metal base, extracting with organic solvent the reaction mixture and adding the same to an anti-solvent to precipitate the product and finally filtering the product to afford amorphous atorvastatin calcium (2:1). The process also comprises the preparation of amorphous atorvastatin calcium salt (2:1) from its crystalline form.

摘要翻译： 用于制备无定形阿托伐他汀钙盐（2:1）的改进方法包括水解图1的式的阿托伐他汀的内酯形式。 1用碱金属或碱土金属碱处理，用有机溶剂萃取反应混合物，并将其加入到反溶剂中沉淀产物，最后过滤产物，得到无定形阿托伐他汀钙（2:1）。 该方法还包括从其结晶形式制备无定形阿托伐他汀钙盐（2:1）。

公开(公告)号：US20070082925A1

公开(公告)日：2007-04-12

申请号：US10576971

申请日：2003-06-06

申请人： Sanjay Suri ,  Jujhar Singh ,  Gurdeep Singh ,  Madan Tamvar ,  Manu Mahendru

发明人： Sanjay Suri ,  Jujhar Singh ,  Gurdeep Singh ,  Madan Tamvar ,  Manu Mahendru

IPC分类号： A61K31/47 ,  C07D215/04

CPC分类号： C07D215/18

摘要： A method for the preparation of montelukast acid sodium salt thereof in amorphous form has been described. The method comprises of following steps: (a) generating the dilithium dianion of 1-(mercaptomethyl)cyclopropane acetic acid, by reacting with alkyl lithium, (b) coupling the said dianion with wet mesylate to get montelukast acid in crude form, (c) obtaining DCHA salt in crude form by adding dicyclohexylamine (DCHA) to crude acid obtained in the above step (b), (d) purifying and converting the said DCHA salt in crude form, to montelukast acid in pure form, and (e) reacting the pure montelukast acid in a polar protic solvent with a source of sodium ion followed by evaporating the solvent and triturating of the residue with non-polar water immiscible solvent.

摘要翻译： 已经描述了制备无定形形式的孟鲁司他酸钠盐的方法。 该方法包括以下步骤：（a）通过与烷基锂反应生成1-（巯基甲基）环丙烷乙酸的二锂二阴离子，（b）将所述二价阴离子与湿甲磺酸酯偶联得到粗制形式的孟鲁司特酸，（c 通过向上述步骤（b）中获得的粗酸加入二环己基胺（DCHA），（d）以粗制形式将所述DCHA盐纯化并转化成纯形式的孟鲁司特酸，得到粗制形式的DCHA盐，和（e） 使极性质子溶剂中的纯孟鲁司特酸与钠离子源反应，然后蒸发溶剂并用非极性水不混溶溶剂研磨残余物。