摘要:
An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS or at risk for AIDS. The peptide has from about 25 to about 37 amino acids, such as, for example, the sequence A T L Y S V 1 H Q R I D V K D T SEQ ID NO. 5 K E A L E K I E E E Q N K S
摘要:
Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the following sequence: (SEQ ID NO:2) 5 10 Ala Thr Leu Xaa Xaa Val His Xaa Xaa Ile Xaa Xaa 15 20 20 Xaa Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu 25 30 35 Glu Gln Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr wherein Xaa at position 4 is Tyr or Trp; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.
摘要:
Improved process for the preparation of amorphous atorvastatin calcium salt (2:1) comprises hydrolyzing the lactone form of atorvastatin of formula of FIG. 1 with aqueous alkali or alkaline earth metal base, extracting with organic solvent the reaction mixture and adding the same to an anti-solvent to precipitate the product and finally filtering the product to afford amorphous atorvastatin calcium (2:1). The process also comprises the preparation of amorphous atorvastatin calcium salt (2:1) from its crystalline form.
摘要:
Peptide fragments of the p17 gag protein of HIV-1 from Clade C of from about 30 to about 50 amino acids, including the region extending from position 75 to position 129, raise antibodies recognizing other subtypes, including Clade A, Clade B, Clade E as well as peptides of non-coextensive but overlapping portions of the p17 gag protein. DNA sequences can be used to encode for the peptides of interest. An example of the Clade C peptide of this invention is a peptide having about 30 to about 32 amino acids taken consecutively from a part or the entirety of the following sequence:(SEQ ID NO:2) 5 10 Ala Thr Leu Xaa Xaa Val His Xaa Xaa Ile Xaa Xaa Xaa - 15 20 25 Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu Glu Gln - 30 35 Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr wherein Xaa at position 4 is Tyr or Trp; Xaa at position 5 is Cys or Ser; Xaa at position 8 is Lys, Glu, or Ala; Xaa at position 9 is Gly, Lys, Asp, Glu, or Arg; Xaa at position 11 is Glu; Xaa at position 12 is Val; Xaa at position 13 is Arg; Xaa at position 21 is Lys; Xaa at position 22 is Ile; Xaa at position 23 is Glu or Lys; Xaa at position 29 is Ile, Ser or Cys; Xaa at position 33 is a direct bond; and Xaa at position 34 is a direct bond.
摘要翻译:含有约30至约50个氨基酸(包括从第75位延伸到第129位的区域)的来自分化蛋白C的HIV-1的p17 gag蛋白的肽片段引起识别其他亚型的抗体,包括分化物A,分支B,分化物E 以及p17 gag蛋白的非共同延伸但重叠部分的肽。 DNA序列可用于编码感兴趣的肽。 本发明的肽C肽的实例是从以下序列的一部分或全部连续取代的具有约30至约32个氨基酸的肽: - (SEQ ID NO:2)-5 10-Ala Thr Leu Xaa Xaa Val他的Xaa Xaa Ile Xaa Xaa Xaa - - 15 20 25 - Asp Thr Lys Glu Ala Leu Asp Xaa Xaa Xaa Glu Glu Gln - - 30 35 - Asn Lys Xaa Gln Gln Lys Xaa Xaa Thr - 其中第4位的Xaa是Tyr 或Trp; 5位的Xaa是Cys或Ser; 位置8处的Xaa是Lys,Glu或Ala; 位置9处的Xaa是Gly,Lys,Asp,Glu或Arg; 位置11的Xaa为Glu; 位置12的Xaa为Val; 13位的Xaa是Arg; 21位的Xaa为Lys; 22号的Xaa是Ile; 第23位的Xaa是Glu或Lys; 第29位的Xaa是Ile,Ser或Cys; 33位的Xaa是直接键; 位置34处的Xaa是直接键合。
摘要:
A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of &bgr;-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as, for example A T L Y S V H Q R I D V K D T (SEQ ID NO: 5) K E A L E K I E E E Q N K S The heteroconjugate is effective in eliciting a THI directed immune response and provides a vaccine composition for treating or preventing AIDS.
摘要:
The present invention describes a process for the preparation of a fraction, mainly containing picroside I and kurrooa, from the plant Picrorhiza kurrooa.
摘要:
A heteroconjugate is formed by linking a T cell binding ligand (TCBL) such as Peptide J of .beta.-2 microglobulin to a modified HGP-30 antigentic peptide fragment of p17 gag peptide, such as. for exampleATL YSV HQR IDV KDTKEA LEK IEE EQN KS (SEQ ID NO: 5)The heteroconjugate is effective in eliciting a THI directed immune response and provides a vaccine composition for treating or preventing AIDS.
摘要:
An antigenic peptide fragment from the p17 gag protein of HIV includes a portion from HGP-30 and a contiguous portion from HGP-35 such that the peptide fragment is capable of inducing a TH1 immune response when administered to a person suffering from AIDS or at risk for AIDS. The peptide has from about 25 to about 37 amino acids, such as, for example, the sequence ##EQU1##