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![Therapeutically useful substituted hydropyrido [3,2,1-ij] quinoline compounds](/abs-image/US/2012/11/13/US08309729B2/abs.jpg.150x150.jpg)
1.发明授权Therapeutically useful substituted hydropyrido [3,2,1-ij] quinoline compounds 失效治疗上有用的取代氢吡啶并[3,2,1-ij]喹啉化合物公开(公告)号：US08309729B2
公开(公告)日：2012-11-13
申请号：US13461398
申请日：2012-05-01
申请人： Santosh C. Sinha , Smita Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael Garst
发明人： Santosh C. Sinha , Smita Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael Garst
IPC分类号： C07D471/00 , C07D451/00 , A61K31/44
CPC分类号： C07D471/04 , C07D471/06
摘要： Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了由结构式表示的化合物：还公开了与之相关的治疗方法，组合物和药物。
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![Therapeutically useful substituted hydropyrido [3,2,1-ij] quinoline compounds](/abs-image/US/2012/05/29/US08188279B2/abs.jpg.150x150.jpg)
公开(公告)号：US08188279B2
公开(公告)日：2012-05-29
申请号：US13150751
申请日：2011-06-01
申请人： Santosh C. Sinha , Smita Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael Garst
发明人： Santosh C. Sinha , Smita Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael Garst
IPC分类号： C07D471/00 , C07D471/06 , A61K31/44
CPC分类号： C07D471/04 , C07D471/06
摘要： Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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![THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-ij] QUINOLINE COMPOUNDS](/abs-image/US/2011/09/29/US20110237797A1/abs.jpg.150x150.jpg)
3.发明申请THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-ij] QUINOLINE COMPOUNDS 失效可治疗有效的替代羟脯氨酸[3,2,1-ij]喹啉化合物公开(公告)号：US20110237797A1
公开(公告)日：2011-09-29
申请号：US13150751
申请日：2011-06-01
申请人： Santosh C. Sinha , Smita Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael Garst
发明人： Santosh C. Sinha , Smita Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael Garst
IPC分类号： C07D471/16 , C07D455/04
CPC分类号： C07D471/04 , C07D471/06
摘要： Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了由结构式表示的化合物：还公开了与之相关的治疗方法，组合物和药物。
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![THERAPEUTICALLY USEFUL SUBSTITUTED 1,7-DIPHENYL-1,2,3,5,6,7-HEXAHYDROPYRIDO[3,2,1-Ij]QUINOLINE COMPOUNDS](/abs-image/US/2009/11/12/US20090281322A1/abs.jpg.150x150.jpg)
4.发明申请THERAPEUTICALLY USEFUL SUBSTITUTED 1,7-DIPHENYL-1,2,3,5,6,7-HEXAHYDROPYRIDO[3,2,1-Ij]QUINOLINE COMPOUNDS 审中-公开可理解地用于取代的1,3-二氢-1,2,3,5,6,7-四氢吡啶并[3,2,1-ij]喹啉化合物公开(公告)号：US20090281322A1
公开(公告)日：2009-11-12
申请号：US12433978
申请日：2009-05-01
申请人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello
IPC分类号： C07D471/06
CPC分类号： C07D471/06 , C07D471/04 , C07D471/16
摘要： Disclosed herein are compounds represented by the structural formula: Therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了由结构式表示的化合物：还公开了与其有关的治疗方法，组合物和药物。
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![THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-ij] QUINOLINE COMPOUNDS](/abs-image/US/2012/12/06/US20120309782A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120309782A1
公开(公告)日：2012-12-06
申请号：US13569418
申请日：2012-08-08
申请人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael E. Garst
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael E. Garst
IPC分类号： A61K31/4745 , A61K31/4375 , A61P9/10 , A61P27/02 , A61P27/06
CPC分类号： C07D471/04 , C07D471/06
摘要： Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
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![THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-ij] QUINOLINE COMPOUNDS](/abs-image/US/2012/08/23/US20120214838A1/abs.jpg.150x150.jpg)
6.发明申请THERAPEUTICALLY USEFUL SUBSTITUTED HYDROPYRIDO [3,2,1-ij] QUINOLINE COMPOUNDS 失效可治疗有效的替代羟脯氨酸[3,2,1-ij]喹啉化合物公开(公告)号：US20120214838A1
公开(公告)日：2012-08-23
申请号：US13461398
申请日：2012-05-01
申请人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael E. Garst
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael E. Garst
IPC分类号： A61K31/4375 , A61P29/00 , A61P25/06 , A61P1/00 , A61P17/02 , A61P11/06 , A61P11/00 , A61P9/00 , A61P9/10 , A61P25/02 , A61P27/02
CPC分类号： C07D471/04 , C07D471/06
摘要： Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了由结构式表示的化合物：还公开了与之相关的治疗方法，组合物和药物。
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![Therapeutically useful substituted hydropyrido [3,2,1-ij] quinoline compounds](/abs-image/US/2013/04/30/US08431702B2/abs.jpg.150x150.jpg)
7.发明授权Therapeutically useful substituted hydropyrido [3,2,1-ij] quinoline compounds 失效治疗上有用的取代氢吡啶并[3,2,1-ij]喹啉化合物公开(公告)号：US08431702B2
公开(公告)日：2013-04-30
申请号：US13569418
申请日：2012-08-08
申请人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael E. Garst
发明人： Santosh C. Sinha , Smita S. Bhat , Ken Chow , Richard L. Beard , John E. Donello , Michael E. Garst
IPC分类号： C07D471/00 , C07D451/00 , A61K31/44
CPC分类号： C07D471/04 , C07D471/06
摘要： Disclosed herein are compounds represented by the structural formula: therapeutic methods, compositions, and medicaments related thereto are also disclosed.
摘要翻译： 本文公开了由结构式表示的化合物：还公开了与之相关的治疗方法，组合物和药物。
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公开(公告)号：US09040532B2
公开(公告)日：2015-05-26
申请号：US13500501
申请日：2010-10-06
申请人： Ken Chow , Liming Wang , Wenkui K. Fang , Evelyn G. Corpuz , Santosh C. Sinha , Daniel W. Gil , Mohammad I. Dibas , John E. Donello
发明人： Ken Chow , Liming Wang , Wenkui K. Fang , Evelyn G. Corpuz , Santosh C. Sinha , Daniel W. Gil , Mohammad I. Dibas , John E. Donello
IPC分类号： A61K31/40 , A61K31/498 , A61K31/4184 , A61K31/4709 , C07D403/12 , C07D401/12 , C07D207/22 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04
CPC分类号： A61K31/498 , A61K31/40 , A61K31/4025 , A61K31/404 , A61K31/4184 , A61K31/435 , A61K31/437 , A61K31/4375 , A61K31/4709 , C07D207/22 , C07D403/12 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , Y10S514/913
摘要： Compounds are described herein useful for treating diseases and conditions by modulation of one or more alpha adrenergic receptor. The compounds can include a naphthalene, a quinoline, a benzoimidazole or an isoquinoline as a core structure. Methods of making, using and formulating these compounds are described.
摘要翻译： 本文描述的化合物可用于通过调节一种或多种α-肾上腺素能受体来治疗疾病和病症。 化合物可以包括萘，喹啉，苯并咪唑或异喹啉作为核心结构。 描述制备，使用和配制这些化合物的方法。
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公开(公告)号：US08071636B2
公开(公告)日：2011-12-06
申请号：US12479129
申请日：2009-06-05
申请人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
发明人： Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha , Daniel W. Gil , John E. Donello
IPC分类号： A01N43/50 , A61K31/415 , C07D233/00
CPC分类号： A61K31/4168
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, both acute and chronic.
摘要翻译： 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性和慢性疼痛的类型。
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10.发明申请公开(公告)号：US20120165380A1
公开(公告)日：2012-06-28
申请号：US13275029
申请日：2011-10-17
申请人： Daniel W. Gil , John E. Donello , Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
发明人： Daniel W. Gil , John E. Donello , Wenkui K. Fang , Phong X. Nguyen , Ken Chow , Todd M. Heidelbaugh , Dario G. Gomez , Michael E. Garst , Santosh C. Sinha
IPC分类号： A61K31/4168 , A61P29/00 , A61P25/00 , C07D233/48
CPC分类号： A61K31/40 , A61K9/0053 , A61K31/4168 , A61K31/4174 , C07D233/48 , C07D233/50
摘要： Described herein are compounds for and methods of treating conditions or diseases in a subject by administering to the subject a pharmaceutical composition containing an effective amount of an α-adrenergic modulator. The compounds and methods are also useful for alleviating types of pain, acute, neuropathic and chronic.
摘要翻译： 本文描述了通过向受试者施用含有有效量的α-肾上腺素能调节剂的药物组合物来治疗受试者的病症或疾病的化合物和方法。 化合物和方法也可用于缓解急性，神经性和慢性疼痛的类型。
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