公开(公告)号：US20240033711A1

公开(公告)日：2024-02-01

申请号：US18258672

申请日：2021-12-21

申请人： Sartorius Stedim Biotech GmbH

发明人： Adrian Ley ,  Rebecca Petersen ,  Florian Taft ,  Patrick Adametz ,  Axel Thiefes ,  Kathrin Toeppner ,  Stella Weber ,  Nils Gehrmann ,  Franziska Hagemann ,  Volkmar Thom

IPC分类号： B01J20/24 ,  B01J20/30 ,  B01J20/28 ,  B01J20/285

CPC分类号： B01J20/24 ,  B01J20/3007 ,  B01J20/28033 ,  B01J20/285 ,  B01J20/28085

摘要： The present invention relates to a chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix for adsorptive material separation in liquid media, and a method of producing the chromatographic material comprising a polymer network material-based self-supporting bi-continuous separation matrix.

公开(公告)号：US11364480B2

公开(公告)日：2022-06-21

申请号：US16479559

申请日：2018-01-16

申请人： Sartorius Stedim Biotech GmbH

发明人： Adrian Ley ,  Florian Taft ,  Jan Schwellenbach ,  Louis Villain

IPC分类号： B01J20/26 ,  B01J20/28 ,  B01J20/286 ,  B01J20/32 ,  C07K1/22

摘要： A chromatography medium includes a porous matrix and nonporous globules bound on the inner and outer surfaces of the porous matrix. The average radius of the microglobules is not more than 30% of the average pore diameter of the porous matrix. The chromatography medium can be used in affinity chromatography. A method for preparing the chromatography medium may include providing a porous starting matrix, providing a polymerization solution, and initiating polymerization of the polymerization solution in the presence of the porous starting matrix to form insoluble nonporous microglobules that are bound to the inner and outer surfaces of the porous starting matrix.