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公开(公告)号：US11576988B2
公开(公告)日：2023-02-14
申请号：US17332969
申请日：2021-05-27
发明人： Marco Leupold , Wei Gao , Stefan Schlack , Christian Grimm
摘要： A sterile packaging unit includes a disposable bioprocessing component (20) and a packaging (30). The disposable bioprocessing component (20) has a component wall that encloses a processing space and on which is secured a sensor system (40) with at least one sensor head (T, P, I, L, D) and with attached sensor electronics (42) that include a memory unit (44). The packaging (30) hermetically encloses the disposable bioprocessing component (20) and has a flexible packaging wall. The disposable bioprocessing component (20) and the packaging (30). are sterilized by being jointly irradiated with ionizing radiation. The sensor electronics (42) are connected electrically to a contact unit (34) extending through the packaging wall.
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公开(公告)号：US11124753B2
公开(公告)日：2021-09-21
申请号：US15577822
申请日：2016-03-08
IPC分类号： C12M1/00 , C12M3/00 , C12M1/02 , C12M1/36 , C12M1/34 , F28D1/06 , B01F15/00 , C12M1/06 , F28D21/00
摘要： A system for receiving a disposable bag (44) has a receiving container (10) with a container interior for receiving the disposable bag (44) and a temperature-control hollow wall (20) that at least partially surrounds the container interior of the receiving container (10). A temperature-control unit controls the temperature of the container interior by will a temperature-control medium arranged in the temperature-control hollow wall (20) at a maximum pressure of about 1 bar.
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公开(公告)号：US20200283710A1
公开(公告)日：2020-09-10
申请号：US16648656
申请日：2018-09-06
IPC分类号： C12M1/00
摘要： A container (1, 1b) of a bioreactor (1a, 1b) has a container interior (22) designed for being filled with a medium (8) including a photoreactive material, and designed for at least partially triggering a photochemical reaction of the photoreactive material. The container (1, 1b) has at least one illuminant receiving pouch (11) that is at least partially transparent for an electromagnetic radiation (14), and that is arranged on a illuminant opening (12) within the container interior (22) and is designed to receive at least one illuminant (15, 15a, 15b, 15c, 15d, 15e) from an outer side (A) through the illuminant opening (12, 12a, 12b). The illuminant at least partially irradiates the medium (8) such that the photochemical reaction of the photoreactive material can be triggered by electromagnetic radiation (14) emitted by the illuminant and the illuminant is isolated in relation to the medium (8) by the illuminant receiving pouch (11).
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公开(公告)号：US20230125762A1
公开(公告)日：2023-04-27
申请号：US17800427
申请日：2020-10-16
发明人： Andreas Prediger , Sina Götemann , Marco Leupold , Jochen Scholz
IPC分类号： C12M1/21 , G01D5/24 , H03K17/955 , G01F23/26 , C12M1/00
摘要： System for detecting at least one presence of foam of a medium in a bioreactor plant, wherein the system comprises: —a bioreactor plant having at least one disposable container for receiving the medium that may comprise the foam; and—at least two capacitive sensor units which are attached at at least two different situating positions of the bioreactor plant, wherein the capacitive sensor units each comprise at least one electrode system for capacitive measurement and are able to detect the presence of foam at the at least two situating positions on the basis of the capacitive measurement; and wherein the capacitive sensor units are designed to transmit captured data relating to the presence of foam to at least one monitoring unit for monitoring, open-loop and/or closed-loop control of foam formation in the bioreactor plant on the basis of said data.
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公开(公告)号：US11542464B2
公开(公告)日：2023-01-03
申请号：US16318604
申请日：2017-07-03
发明人： Christian Grimm , Wei Gao , Marco Leupold
摘要： A single use probe, sterilizable by irradiation, for a single use component for use in a biopharmaceutical process, comprises at least one sensor relevant for the biopharmaceutical process, an RFID tag and a memory rewritable in principle, in which data with respect to an integrity check of the single use probe are stored. A method for quality assurance of such a single use probe comprises: providing the probe with an RFID tag and a memory rewritable in principle, in particular a FeRAM memory as part of the RFID tag; defining a measurement-principle-specific quality parameter of the single use probe; defining a tolerance value for the parameter; performing an integrity check of the probe by first determining and writing into the memory values of the defined quality parameter before sterilization of the probe by irradiation; determining the values of the defined quality parameter after irradiation; and comparing the values of the quality parameter determined before radiation to those determined after.
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公开(公告)号：US20210283283A1
公开(公告)日：2021-09-16
申请号：US17332969
申请日：2021-05-27
发明人： Marco Leupold , Wei Gao , Stefan Schlack , Christian Grimm
摘要： A sterile packaging unit includes a disposable bioprocessing component (20) and a packaging (30). The disposable bioprocessing component (20) has a component wall that encloses a processing space and on which is secured a sensor system (40) with at least one sensor head (T, P, I, L, D) and with attached sensor electronics (42) that include a memory unit (44). The packaging (30) hermetically encloses the disposable bioprocessing component (20) and has a flexible packaging wall. The disposable bioprocessing component (20) and the packaging (30). are sterilized by being jointly irradiated with ionizing radiation. The sensor electronics (42) are connected electrically to a contact unit (34) extending through the packaging wall.
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公开(公告)号：US20180280553A1
公开(公告)日：2018-10-04
申请号：US15763609
申请日：2016-09-22
发明人： Marco Leupold , Wei Gao , Stefan Schlack , Christian Grimm
摘要： A sterile packaging unit includes a disposable bioprocessing component (20) and a packaging (30). The disposable bioprocessing component (20) has a component wall that encloses a processing space and on which is secured a sensor system (40) with at least one sensor head (T, P, I, L, D) and with attached sensor electronics (42) that include a memory unit (44). The packaging (30) hermetically encloses the disposable bioprocessing component (20) and has a flexible packaging wall. The disposable bioprocessing component (20) and the packaging (30). are sterilized by being jointly irradiated with ionizing radiation. The sensor electronics (42) are connected electrically to a contact unit (34) extending through the packaging wall.
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公开(公告)号：US20180187140A1
公开(公告)日：2018-07-05
申请号：US15577574
申请日：2016-03-08
CPC分类号： C12M29/26 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/28 , C12M23/38 , C12M23/48 , C12M27/02 , C12M41/00 , C12M41/12
摘要： A bioreactor (1; 2; 3) includes a receiving container (10) for receiving a disposable bag (44). A bottom surface (11) of the receiving container (10) is designed to support the disposable bag (44) in the receiving container (10). An outlet opening (5) is formed in the bottom surface (11) and tapers down with respect to the ground for receiving a drain port (45) of the disposable bag (44). The drain port is complementary to the outlet opening (5).
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公开(公告)号：US12129457B2
公开(公告)日：2024-10-29
申请号：US16648656
申请日：2018-09-06
IPC分类号： C12M1/00
摘要： A container (1, 1b) of a bioreactor (1a, 1b) has a container interior (22) designed for being filled with a medium (8) including a photoreactive material, and designed for at least partially triggering a photochemical reaction of the photoreactive material. The container (1, 1b) has at least one illuminant receiving pouch (11) that is at least partially transparent for an electromagnetic radiation (14), and that is arranged on a illuminant opening (12) within the container interior (22) and is designed to receive at least one illuminant (15, 15a, 15b, 15c, 15d, 15e) from an outer side (A) through the illuminant opening (12, 12a, 12b). The illuminant at least partially irradiates the medium (8) such that the photochemical reaction of the photoreactive material can be triggered by electromagnetic radiation (14) emitted by the illuminant and the illuminant is isolated in relation to the medium (8) by the illuminant receiving pouch (11).
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公开(公告)号：US11827874B2
公开(公告)日：2023-11-28
申请号：US17156701
申请日：2021-01-25
CPC分类号： C12M29/26 , C12M23/14 , C12M23/22 , C12M23/26 , C12M23/28 , C12M23/38 , C12M23/48 , C12M27/02 , C12M41/00 , C12M41/12
摘要： A bioreactor (1; 2; 3) includes a receiving container (10) for receiving a disposable bag (44). A bottom surface (11) of the receiving container (10) is designed to support the disposable bag (44) in the receiving container (10). An outlet opening (5) is formed in the bottom surface (11) and tapers down with respect to the ground for receiving a drain port (45) of the disposable bag (44). The drain port is complementary to the outlet opening (5).
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