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公开(公告)号：US20050227913A1
公开(公告)日：2005-10-13
申请号：US11049134
申请日：2005-02-02
IPC分类号： A61K9/127 , A61K38/17 , A61K38/37 , C07K14/775
CPC分类号： A61K9/1075 , A61K9/127 , A61K9/1274 , A61K38/37 , C07K14/21 , C07K2319/00 , C07K2319/04
摘要： Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes.
摘要翻译： 描述低免疫原性蛋白质，多肽或肽制剂的方法和组成。 该方法包括形成蛋白质，多肽或肽与可以是含丝氨酸化合物或其它磷脂酰基化合物或磷脂的结合剂的复合物。 所形成的复合物包括简单的复合物，胶束，耳蜗结构，脂质体，非双层和新型脂质结构。 在形成这种复合物时，蛋白质，多肽或肽的抗原性和致死性降低。
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2.发明申请Method of complexing a protein by the use of a dispersed system and proteins thereof 有权通过使用分散系统和蛋白质来络合蛋白质的方法公开(公告)号：US20050026242A1
公开(公告)日：2005-02-03
申请号：US10872638
申请日：2004-06-21
CPC分类号： C12P21/02 , A61K9/127 , A61K9/1271 , A61K38/37 , A61K38/47 , A61K47/10 , A61K47/18 , C07K1/1077 , C07K14/755 , C12N9/2462 , C12Y302/01017
摘要： The present invention relates to methods for complexing a protein in a dispersed medium. Also disclosed are associated proteins produced by the methods of complexing of the present invention. Pharmaceutically effective stabilized protein dosages are also disclosed. The present invention also relates to a method for associating AHF protein in a dispersed medium.
摘要翻译： 本发明涉及在分散介质中络合蛋白质的方法。 还公开了通过本发明的络合方法产生的相关蛋白质。 还公开了药学上有效的稳定蛋白质剂量。 本发明还涉及在分散介质中使AHF蛋白质结合的方法。
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公开(公告)号：US20050069578A1
公开(公告)日：2005-03-31
申请号：US10911865
申请日：2004-08-05
摘要： Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties.
摘要翻译： 提供了可用于重构含有蛋白质/肽药物的浓缩制剂的组合物。 组合物通常包括一种或多种脂质，以及促进和稳定（a）具有更大蛋白质包封的脂质分子组装形成的一种或多种醇; （b）蛋白质 - 脂质复合物和（c）蛋白质和脂质溶液。 重建培养基改善了蛋白质 - 脂质缔合，从而改变药物性质。
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