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1.发明申请Method Of Complexing A Protein By The Use Of A Dispersed System And Proteins Thereof 审中-公开通过使用分散系统和蛋白质使蛋白质复合的方法公开(公告)号：US20100105870A1
公开(公告)日：2010-04-29
申请号：US12606445
申请日：2009-10-27
申请人： Sathyamangalam V. Balasubramanian , Robert M. Straubinger , Karthik Ramani , Marc Besman , Ramesh Kashi
发明人： Sathyamangalam V. Balasubramanian , Robert M. Straubinger , Karthik Ramani , Marc Besman , Ramesh Kashi
IPC分类号： C07K14/555 , C07K1/00 , C07K14/755
CPC分类号： C12P21/02 , A61K9/127 , A61K9/1271 , A61K38/37 , A61K38/47 , A61K47/10 , A61K47/18 , C07K1/1077 , C07K14/755 , C12N9/2462 , C12Y302/01017
摘要： The present invention relates to methods for complexing a protein in a dispersed medium. Also disclosed are associated proteins produced by the methods of complexing of the present invention. Pharmaceutically effective stabilized protein dosages are also disclosed. The present invention also relates to a method for associating AHF protein in a dispersed medium.
摘要翻译： 本发明涉及在分散介质中络合蛋白质的方法。 还公开了通过本发明的络合方法产生的相关蛋白质。 还公开了药学上有效的稳定蛋白质剂量。 本发明还涉及在分散介质中使AHF蛋白质结合的方法。
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2.发明授权Method of complexing a protein by the use of a dispersed system and proteins thereof 有权通过使用分散系统和蛋白质来络合蛋白质的方法公开(公告)号：US07625584B2
公开(公告)日：2009-12-01
申请号：US10872638
申请日：2004-06-21
申请人： Sathyamangalam V. Balasubramanian , Robert M. Straubinger , Karthik Ramani , Marc Besman , Ramesh Kashi
发明人： Sathyamangalam V. Balasubramanian , Robert M. Straubinger , Karthik Ramani , Marc Besman , Ramesh Kashi
IPC分类号： A61K9/127
CPC分类号： C12P21/02 , A61K9/127 , A61K9/1271 , A61K38/37 , A61K38/47 , A61K47/10 , A61K47/18 , C07K1/1077 , C07K14/755 , C12N9/2462 , C12Y302/01017
摘要： The present invention relates to methods for complexing a protein in a dispersed medium. Also disclosed are associated proteins produced by the methods of complexing of the present invention. Pharmaceutically effective stabilized protein dosages are also disclosed. The present invention also relates to a method for associating AHF protein in a dispersed medium.
摘要翻译： 本发明涉及在分散介质中络合蛋白质的方法。 还公开了通过本发明的络合方法产生的相关蛋白质。 还公开了药学上有效的稳定蛋白质剂量。 本发明还涉及在分散介质中使AHF蛋白质结合的方法。
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公开(公告)号：US07351688B2
公开(公告)日：2008-04-01
申请号：US11049134
申请日：2005-02-02
IPC分类号： A61K38/00
CPC分类号： A61K9/1075 , A61K9/127 , A61K9/1274 , A61K38/37 , C07K14/21 , C07K2319/00 , C07K2319/04
摘要： Methods and composition are described for low immunogenic protein, polypeptide or peptide formulations. The method comprises forming complexes of the protein, polypeptide or peptide with a binding agent which can be a serine containing compound or other phosphatidyl compounds or phospholipids. The complexes formed include simple complexes, micelles, cochleate structures, liposomes, non-bilayer and novel lipidic structures. The antigenicity and imminogenicity of the protein, polypeptides or peptides is reduced upon formation of such complexes.
摘要翻译： 描述低免疫原性蛋白质，多肽或肽制剂的方法和组成。 该方法包括形成蛋白质，多肽或肽与可以是含丝氨酸化合物或其它磷脂酰基化合物或磷脂的结合剂的复合物。 所形成的复合物包括简单的复合物，胶束，耳蜗结构，脂质体，非双层和新型脂质结构。 在形成这种复合物时，蛋白质，多肽或肽的抗原性和致死性降低。
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公开(公告)号：US06348215B1
公开(公告)日：2002-02-19
申请号：US09684115
申请日：2000-10-06
IPC分类号： A61K9127
CPC分类号： C07D305/14 , A61K9/127
摘要： The invention provides a method of stabilizing a taxane in a dispersed system, which method comprises exposing the taxane to a molecule which improves physical stability of the taxane in the dispersed system. By improving physical stability of the taxane in the dispersed system, higher taxane content can be achieved. The invention thus further provides a stable taxane-containing liposome preparation comprising a liposome containing one or more taxanes present in the liposome in an amount of less than 20 mol % total taxane to liposome, wherein the liposome is suspended in a glycerol:water composition having at least 30% glycerol.
摘要翻译： 本发明提供了一种在分散体系中稳定紫杉烷的方法，该方法包括将紫杉烷暴露于改善分散体系中紫杉烷的物理稳定性的分子。 通过提高分散体系中紫杉烷的物理稳定性，可以实现更高的紫杉烷含量。 因此，本发明进一步提供了一种稳定的含紫杉烷的脂质体制剂，其包含含有脂质体中存在的一种或多种紫杉烷的脂质体，其量小于20mol％总紫杉烷与脂质体，其中所述脂质体悬浮于具有 至少30％的甘油。
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公开(公告)号：US08349794B2
公开(公告)日：2013-01-08
申请号：US12204922
申请日：2008-09-05
摘要： Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties.
摘要翻译： 提供了可用于重构含有蛋白质/肽药物的浓缩制剂的组合物。 组合物通常包括一种或多种脂质，以及促进和稳定（a）具有更大蛋白质包封的脂质分子组装形成的一种或多种醇; （b）蛋白质 - 脂质复合物和（c）蛋白质和脂质溶液。 重建培养基改善了蛋白质 - 脂质缔合，从而改变药物性质。
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公开(公告)号：US20090062205A1
公开(公告)日：2009-03-05
申请号：US12204922
申请日：2008-09-05
摘要： Compositions useful for reconstitution of concentrated formulations containing protein/peptide pharmaceuticals are provided. The composition generally includes one or more lipids, as well as one or more alcohols that promote and stabilize the formation of (a) lipid molecular assemblies with greater protein encapsulation; (b) protein-lipid complexes and (c) protein and lipid solutions. The reconstitution medium improves the protein-lipid association that in turn alters the pharmaceutical properties.
摘要翻译： 提供了可用于重构含有蛋白质/肽药物的浓缩制剂的组合物。 组合物通常包括一种或多种脂质，以及促进和稳定（a）具有更大蛋白质包封的脂质分子组装形成的一种或多种醇; （b）蛋白质 - 脂质复合物和（c）蛋白质和脂质溶液。 重建培养基改善了蛋白质 - 脂质缔合，从而改变药物性质。
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