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公开(公告)号：US6107465A
公开(公告)日：2000-08-22
申请号：US24386
申请日：1987-03-10
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： A61K38/00 , C07K14/545 , C12N15/24 , C07K14/54 , A61K38/20
CPC分类号： C07K14/545 , A61K38/00 , Y10S930/141
摘要： A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
摘要翻译： 白细胞介素1β（IL-1β），其衍生物具有IL-1β的修饰的氨基酸序列，编码所述衍生物的基因，包含所述衍生物作为药学上有效成分的药物组合物和均匀的IL -1 beta和衍生物。
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公开(公告)号：US5543140A
公开(公告)日：1996-08-06
申请号：US252229
申请日：1994-06-01
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12N15/25 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , F16L5/02 , A61K38/20
CPC分类号： C07K14/545 , F16L5/02 , A61K38/00 , Y10S514/825 , Y10S514/886 , Y10S530/82
摘要： Methods for stimulating immunity, inhibiting tumor growth, promoting production of a cytokine, and preventing or inhibiting radiation injury by administration of Interleukin-1.alpha. (IL-1.alpha.) derivatives, are disclosed.
摘要翻译： 公开了刺激免疫，抑制肿瘤生长，促进细胞因子产生以及通过施用白细胞介素-1α（IL-1α）衍生物预防或抑制放射性损伤的方法。
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3.发明授权Antitumor active substance, process for preparing the same, drug containing the substance, gene coding for the substance, vector containing the gene and recombinant microorganism 失效抗肿瘤活性物质，其制备方法，含有物质的药物，编码该物质的基因，含有该基因的载体和重组微生物
公开(公告)号：US4898818A
公开(公告)日：1990-02-06
申请号：US810776
申请日：1985-12-19
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： A61K38/00 , C07K14/545 , C12N15/12
CPC分类号： C07K14/545 , A61K38/00
摘要： This invention provides an antitumor active substance GIF, a process for preparing the same, an antitumor composition containing the substance, a gene coding for GIF, a vector containing the gene and a recombinant microorganism, the substance GIF comprises as its component protein polypeptide A of the following primary structure. ##STR1## wherein X is Cys or Ser and Z is H or a peptide represented by the amino acid sequence ##STR2## or a peptide having the above sequence wherein at least one amino acid is removed from the N terminal or an amino acid.
摘要翻译： 本发明提供了一种抗肿瘤活性物质GIF，其制备方法，含有该物质的抗肿瘤组合物，编码GIF的基因，含该基因的载体和重组微生物，该GIF物质作为其成分的蛋白多肽A 以下主要结构。 其中X为Cys或Ser，Z为H或由氨基酸序列“IMAGE”表示的肽或具有上述序列的肽，其中至少一个氨基酸从N末端或氨基酸中除去。
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公开(公告)号：US5008374A
公开(公告)日：1991-04-16
申请号：US23373
申请日：1987-03-09
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12N15/25 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , F16L5/02
CPC分类号： C07K14/545 , F16L5/02 , A61K38/00 , Y10S514/825 , Y10S514/886 , Y10S530/82
摘要： An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..
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公开(公告)号：US5847098A
公开(公告)日：1998-12-08
申请号：US474168
申请日：1995-06-07
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： A61K38/00 , C07K14/545 , C12N15/24 , C12N5/10
CPC分类号： C07K14/545 , A61K38/00 , Y10S514/825 , Y10S514/886
摘要： A homogeneous interleukin 1.beta. (IL-1.beta.), its derivative having a modified amino acid sequence of IL-1.beta., a gene coding for said derivative, medical composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.beta. and the derivative.
摘要翻译： 白细胞介素1β（IL-1β），其衍生物具有IL-1β的修饰的氨基酸序列，编码所述衍生物的基因，包含所述衍生物作为药学上有效成分的药物组合物和均匀的IL -1 beta和衍生物。
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公开(公告)号：US5702698A
公开(公告)日：1997-12-30
申请号：US461733
申请日：1995-06-05
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12N15/25 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , F16L5/02 , A61K38/20
CPC分类号： C07K14/545 , F16L5/02 , A61K38/00 , Y10S514/825 , Y10S514/886 , Y10S530/82
摘要： Methods are disclosed for promoting production of colony stimulating factor and inhibiting growth of Meth A tumor cells comprising administering a pharmaceutically effective amount of modified IL-1.alpha. to a subject.
摘要翻译： 公开了用于促进集落刺激因子的产生和抑制Meth A肿瘤细胞生长的方法，包括向受试者施用药学有效量的经修饰的IL-1α。
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公开(公告)号：US5371204A
公开(公告)日：1994-12-06
申请号：US643292
申请日：1991-01-22
申请人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
发明人： Satoru Nakai , Mayumi Kaneta , Yoshikazu Kikumoto , Yeong-Man Hong , Kazuyoshi Kawai , Setsuko Takegata , Kiyoshi Ishii , Yasuo Yanagihara , Yoshikatsu Hirai
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/04 , A61P43/00 , C07K14/00 , C07K14/52 , C07K14/54 , C07K14/545 , C12N15/25 , C12P21/02 , C12R1/125 , C12R1/19 , C12R1/865 , C12R1/91 , F16L5/02 , C12P13/02
CPC分类号： C07K14/545 , F16L5/02 , A61K38/00 , Y10S514/825 , Y10S514/886 , Y10S530/82
摘要： An interleukin-1.alpha. (IL-1.alpha.) derivative having a modified amino acid sequence of IL-1.alpha., a gene coding for said derivative, medicinal composition comprising said derivative as a pharmaceutically effective component and a medicinal use of homogeneous IL-1.alpha..
摘要翻译： 具有IL-1α修饰氨基酸序列的白细胞介素-1α（IL-1α）衍生物，编码所述衍生物的基因，包含所述衍生物作为药学上有效成分的药物组合物和均匀的IL-1 α 。
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8.发明授权
公开(公告)号：US5120534A
公开(公告)日：1992-06-09
申请号：US386073
申请日：1989-07-28
申请人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
发明人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
IPC分类号： A61K38/00 , C07K14/545
CPC分类号： C07K14/545 , A61K38/00
摘要： The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a IL-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.
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公开(公告)号：US5756675A
公开(公告)日：1998-05-26
申请号：US254419
申请日：1994-06-06
申请人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
发明人： Yoshikatsu Hirai , Satoru Nakai , Koutoku Aihara , Kazuyoshi Kawai , Mayumi Kaneta , Takashi Kamogashira , Yoshihiro Masui
IPC分类号： A61K38/00 , C07K14/545 , C07K14/54
CPC分类号： C07K14/545 , A61K38/00
摘要： The present invention provides a medicament for treating thrombocytopenia comprising as an active component at least one polypeptide selected from IL-1 and derivative thereof and a Il-1.alpha. derivative having an amino acid sequence of the formula (.alpha.) which is so modified as to fulfill at least one of the requirements of: deletion of the 16-position Arg; replacement of the 16-position Arg by another amino acid residue; deletion of the sequence of the 1-position Ser to the 14-position Phe and deletion of the amino acid sequence of the 1-position Ser to the 15-position Met.
摘要翻译： 本发明提供了治疗血小板减少症的药物，其包含至少一种选自IL-1及其衍生物的多肽作为活性成分和具有式（α）的氨基酸序列的II-1α衍生物，其被修饰为 满足至少一项要求：删除16位Arg; 用另一个氨基酸残基取代16位Arg; 将1位Ser序列删除至14位Phe，并将1位Ser的氨基酸序列缺失至15位Met。
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10.发明授权Method of treating colon, renal, and lung carcinomas with .gamma.-interferon and �Ser.sup.71 !-interleukin-1.beta. 失效用γ-干扰素和[Ser71] - 白细胞介素-1β治疗结肠癌，肾癌和肺癌的方法
公开(公告)号：US5849282A
公开(公告)日：1998-12-15
申请号：US173866
申请日：1993-12-23
申请人： Kazuyoshi Kawai , Yasue Konishi , Satoru Nakai , Yoshikatsu Hirai
发明人： Kazuyoshi Kawai , Yasue Konishi , Satoru Nakai , Yoshikatsu Hirai
CPC分类号： A61K9/0019 , A61K38/217 , A61K47/183 , A61K9/19
摘要： This invention provides an anti-tumor agent and a method for treating a tumor wherein gamma-interferon and interleukin-1 are used as active ingredients.
摘要翻译： 本发明提供抗肿瘤剂和治疗肿瘤的方法，其中使用γ-干扰素和白细胞介素-1作为活性成分。
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