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    Method for anticipating sensitivity to medicine for osteoporosis
    3.
    发明授权
    Method for anticipating sensitivity to medicine for osteoporosis 失效
    预测骨质疏松症药物敏感度的方法

    公开(公告)号：US06566064B1

    公开(公告)日：2003-05-20

    申请号：US09572891

    申请日：2000-05-18

    申请人： Masataka Shiraki ,  Yasuyoshi Ouchi ,  Takayuki Hosoi ,  Nobutaka Kusaba ,  Toshiaki Baba ,  Hiroshi Yoshida

    发明人： Masataka Shiraki ,  Yasuyoshi Ouchi ,  Takayuki Hosoi ,  Nobutaka Kusaba ,  Toshiaki Baba ,  Hiroshi Yoshida

    IPC分类号： C12Q168

    CPC分类号： C12Q1/6883 ,  C12Q2600/106 ,  C12Q2600/156

    摘要： A method for anticipating sensitivity to a medicine for osteoporosis is provided which is characterized by analyzing respective genetic polymorphisms of a vitamin D receptor gene, an estrogen receptor gene, and an apolipoprotein E gene from a genome DNA contained in a sample obtained from a human, and anticipating, based on the analyzed combination of the genetic polymorphisms, that the sample is derived from an individual who shows a specific priority to sensitivities to a plurality of remedies for osteoporosis. A reagent for simultaneously detecting genetic polymorphisms is also provided which contains amplification primers and/or detection probes specific to respective genes of the vitamin D receptor gene, apolipoprotein E gene, and estrogen receptor gene. Further, a method for simultaneously detecting these genes, and a method for selecting remedies for bone disease based on the genetic polymorphisms are provided. According to the method of the present invention, a diagnosis as to which remedy, or medicine, for osteoporosis a subject patient has higher sensitivity can be made before the administration of the medicine so that selection of an appropriate medicine is possible and the QOL (quality of life) of the patient can be improved.

    摘要翻译： 本发明提供一种用于预测对于骨质疏松症药物的敏感性的方法，其特征在于分析来自人获得的样品中含有的基因组DNA中的维生素D受体基因，雌激素受体基因和载脂蛋白E基因的遗传多态性， 并且基于所分析的遗传多态性的组合，预期样品来源于对多种骨质疏松症的治疗方案具有特定优先权的个体。 还提供了用于同时检测遗传多态性的试剂，其包含对维生素D受体基因，载脂蛋白E基因和雌激素受体基因的各自基因特异的扩增引物和/或检测探针。 此外，提供了同时检测这些基因的方法，以及基于遗传多态性选择骨疾病补救方法。 根据本发明的方法，可以在给药之前进行对患者具有较高敏感性的骨质疏松症的补救或药物的诊断，以便选择合适的药物是可行的，并且生活质量 的生命）可以改善。

    Estimation of change in bone mineral density and diagnosis of osteoporosis
    4.
    发明授权
    Estimation of change in bone mineral density and diagnosis of osteoporosis 失效
    骨矿物质密度变化和骨质疏松症诊断的估计

    公开(公告)号：US6008005A

    公开(公告)日：1999-12-28

    申请号：US603121

    申请日：1996-02-20

    申请人： Masataka Shiraki ,  Jui-Tung Chen ,  Ikuo Morita ,  Naoko Maruo

    发明人： Masataka Shiraki ,  Jui-Tung Chen ,  Ikuo Morita ,  Naoko Maruo

    IPC分类号： G01N33/50 ,  C12P21/08 ,  G01N33/53 ,  G01N33/68 ,  C07K16/00 ,  G01N21/76

    CPC分类号： G01N33/6869

    摘要： A method for estimation of change in bone mineral density or a method for diagnosis of osteoporosis, comprising the step of measuring change in a concentration of soluble interleukin-6 receptor in a blood sample, by for example, sandwich assay or competition assay; and a kit for carrying out said methods, comprising:(1) an anti-sIL-6R antibody immobilized to a solid carrier, and(2) an anti-sIL-6R antibody is bound to a detectable marker or capable of binding to a detectable marker.

    摘要翻译： 一种评价骨矿物质密度变化的方法或骨质疏松症诊断方法，其特征在于，包括测定血液样品中可溶性白细胞介素-6受体浓度的变化的步骤，例如，夹心测定法，竞赛法等。 以及用于实施所述方法的试剂盒，其包含：（1）固定在固体载体上的抗-SIL-6R抗体，和（2）抗-SIL-6R抗体与可检测标记结合或能够结合至 可检测标记。

    Method and system for supporting maintenance for a molding system
    5.
    发明授权
    Method and system for supporting maintenance for a molding system 失效
    支持模塑系统维护的方法和系统

    公开(公告)号：US06615159B1

    公开(公告)日：2003-09-02

    申请号：US09518406

    申请日：2000-03-03

    申请人： Tadashi Nishida ,  Minoru Kondo ,  Kazuya Nishikore ,  Masataka Shiraki

    发明人： Tadashi Nishida ,  Minoru Kondo ,  Kazuya Nishikore ,  Masataka Shiraki

    IPC分类号： G21C1700

    CPC分类号： G05B23/0283 ,  B22C19/04

    摘要： A method and system is provided to determine or estimate components that may have to be maintained before a molding system that has those components is caused to be stopped by problems with those components. Cycle times that each correspond to the time of the cycle of each operation of the molding system and operation times of the steps performed by the components, which operation times affect the cycle times, are measured and stored. Based on the sum of the operation times that exceed a predetermined time or the sum of the number of operation times that exceed the predetermined time, any step that may cause a problem among the steps of the components, which affect the cycle time, is determined.

    摘要翻译： 提供了一种方法和系统来确定或估计在具有那些部件的模制系统由于那些部件的问题而被停止的情况下可能必须维护的部件。 测量和存储每个对应于模制系统的每个操作的周期的时间和由组件执行的步骤的操作时间的循环时间，操作时间影响循环时间。 基于超过预定时间的操作时间的总和或超过预定时间的操作次数的总和，确定可能导致影响循环时间的部件的步骤中的问题的任何步骤 。

    Estimation of change in bone mineral density and diagnosis of osteoporosis
    6.
    发明授权
    Estimation of change in bone mineral density and diagnosis of osteoporosis 失效
    骨矿物质密度变化和骨质疏松症诊断的估计

    公开(公告)号：US06258552B1

    公开(公告)日：2001-07-10

    申请号：US08603121

    申请日：1996-02-20

    申请人： Masataka Shiraki ,  Jui-Tung Chen ,  Ikuo Morita ,  Naoko Maruo

    发明人： Masataka Shiraki ,  Jui-Tung Chen ,  Ikuo Morita ,  Naoko Maruo

    IPC分类号： G01N3353

    CPC分类号： G01N33/6869

    摘要： A method for estimation of change in bone mineral density or a method for diagnosis of osteoporosis, comprising the step of measuring change in a concentration of soluble interleukin-6 receptor in a blood sample, by for example, sandwich assay or competition assay; and a kit for carrying out the methods, comprising: (1) an anti-sIL-6R antibody immobilized to a solid carrier, and (2) an anti-sIL-6R antibody bound to a detectable marker or capable of binding to a detectable marker.

    摘要翻译： 一种评价骨矿物质密度变化的方法或骨质疏松症诊断方法，其特征在于，包括测定血液样品中可溶性白细胞介素-6受体浓度的变化的步骤，例如，夹心测定法，竞赛法等。 以及用于进行所述方法的试剂盒，其包括：（1）固定在固体载体上的抗-SIL-6R抗体，和（2）结合可检测标记或能够结合可检测标记的抗sIL-6R抗体 标记。