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公开(公告)号：US4990693A
公开(公告)日：1991-02-05
申请号：US465892
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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2.发明授权Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效新型物质KS-504a，KS-504b，KS-504d和KS-504e及其制备方法
公开(公告)号：US4983775A
公开(公告)日：1991-01-08
申请号：US465893
申请日：1990-01-16
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances Ks-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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3.发明授权Novel substances KS-504a, KS-504b, KS-504d and KS-504e and process for their preparation 失效新型物质KS-504a，KS-504b，KS-504d和KS-504e及其制备方法
公开(公告)号：US4912132A
公开(公告)日：1990-03-27
申请号：US181702
申请日：1988-04-14
申请人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
发明人： Satoshi Nakanishi , Koji Yamada , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Noriaki Hirayama , Hiroshi Kase , Joji Goto , Etsuyo Shimizu
CPC分类号： C12R1/645 , C07C35/48 , C07C45/58 , C07C47/46 , C07D303/48 , C12P17/02 , C12P7/02 , C12P7/24
摘要： Novel physiologically active substances KS-504a, KS-504b and KS-504d having a vasodilative activity and a novel physiologically active substance KS-504e having an activity to inhibit histamine secretion are produced by culturing a microorganism of the genus Mollisia.
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4.发明授权
公开(公告)号：US4868159A
公开(公告)日：1989-09-19
申请号：US165738
申请日：1988-03-09
申请人： Satoshi Nakanishi , Koji Yamada , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Hiroshi Kase
发明人： Satoshi Nakanishi , Koji Yamada , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Toru Yasuzawa , Hiroshi Kase
IPC分类号： C07H15/203 , C12P19/44
CPC分类号： C07H15/203 , C12P19/44 , C12R1/645
摘要： Novel physiologically active substances KS-501 and KS-502 having inhibitory activity on serotonin release from platelets and/or platelet aggregation are produced by culturing a microorganism of the genus Sporothrix.
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公开(公告)号：US5223637A
公开(公告)日：1993-06-29
申请号：US889388
申请日：1992-05-28
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C323/20 , C07C327/26 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
摘要翻译： 通过培养属于被孢霉属属的微生物来产生具有抑制环核苷酸磷酸二酯酶的活性的KS-506a，KS-506x和KS-506g以及具有抑制组胺释放活性的KS-506m和KS-506h。
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公开(公告)号：US5142096A
公开(公告)日：1992-08-25
申请号：US329329
申请日：1989-03-27
申请人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
发明人： Kazutoshi Kuroda , Hiroshi Kase , Katsuhiko Ando , Isao Kawamoto , Toru Yasuzawa , Hiroshi Sano , Joji Goto , Koji Yamada
IPC分类号： C07C323/20 , C07C327/26 , C12P7/00
CPC分类号： C07C327/26 , C07C323/20 , C12P7/00
摘要： KS-506a, KS-506x and KS-506g having an activity to inhibit cyclic nucleotide phosphodiesterase and KS-506m and KS-506h having an activity to inhibit histamine release are produced by culturing a microorganism belonging to the genus Mortierella.
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公开(公告)号：US5004833A
公开(公告)日：1991-04-02
申请号：US408192
申请日：1989-09-15
申请人： Toru Yasuzawa , Satoshi Nakanishi , Chikara Murakata , Hiroshi Kase , Hiroshi Sano , Koji Yamada
发明人： Toru Yasuzawa , Satoshi Nakanishi , Chikara Murakata , Hiroshi Kase , Hiroshi Sano , Koji Yamada
IPC分类号： C07H15/203
CPC分类号： C07H15/203
摘要： Disclosed are KS-501 derivatives represented by the formula (I) ##STR1## wherein X represents a hydrogen atom or COOR.sub.3, Y represents hydroxy or ##STR2## and R.sub.1, R.sub.2 and R.sub.3 are the same or different and represent a hydrogen atom or an alkyl group having 1 to 4 carbon atoms, provided that when R.sub.1, R.sub.2 and R.sub.3 are simultaneously hydrogen atoms, and when R.sub.1, R.sub.2 and X are simultaneously hydrogen atoms, Y does not represent ##STR3## and a pharmaceutically acceptable acid addition salt thereof. The KS-501 derivatives have a platelet aggregation-inhibiting property, and are expected to be useful as antithrombotic agent.
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公开(公告)号：US5132112A
公开(公告)日：1992-07-21
申请号：US682349
申请日：1991-04-09
申请人： Yoshikazu Morishita , Mitsuru Takahashi , Koji Yamada , Tomoyuki Sano , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Yutaka Saito , Hiroshi Kase , Yuzuru Matsuda
发明人： Yoshikazu Morishita , Mitsuru Takahashi , Koji Yamada , Tomoyuki Sano , Isao Kawamoto , Katsuhiko Ando , Hiroshi Sano , Yutaka Saito , Hiroshi Kase , Yuzuru Matsuda
IPC分类号： A61K31/70 , A61K31/7024 , A61P9/02 , A61P13/02 , A61P15/00 , C07H13/06 , C08B37/00 , C12P19/04 , C12R1/645
CPC分类号： C08B37/0024 , C12P19/04
摘要： Compounds comprising a linear .beta.1.fwdarw.6 glucan esterified by caproic acid, the number of D-glucose residues being from 7 to 40 and the number of caproic acid residues being from 2 to 30, may be be obtained by fermentation of a microorganism of the genus Aureobasidium. These compounds are designated HS-142-1. Preferred microorganism is Aureobasidium pullulans var. melanigenum KAC-2383 (FERM-BP 2407).The compounds of the present invention exhibit excellent antagonistic activity to ANP and are capable of inhibiting the bonding of ANP to ANP receptors.
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9.发明授权Hydroxamic acid derivatives and use thereof in combatting lipoxygenase-mediated diseases 失效羟肟酸衍生物及其在抗氧化酶介导的疾病中的应用
公开(公告)号：US5011854A
公开(公告)日：1991-04-30
申请号：US281050
申请日：1989-12-07
申请人： Mitsuru Takahashi , Shigeto Kitamura , Hiroshi Kase , Masaji Kasai , Isao Kawamoto , Takao Iida , Hiroshi Sano , Hiromitsu Saito , Koji Yamada , Chikara Murakata
发明人： Mitsuru Takahashi , Shigeto Kitamura , Hiroshi Kase , Masaji Kasai , Isao Kawamoto , Takao Iida , Hiroshi Sano , Hiromitsu Saito , Koji Yamada , Chikara Murakata
IPC分类号： C07C239/16 , C07C259/06
CPC分类号： C07C239/16 , C07C259/06
摘要： A hydroxamic acid compound represented by the general formula (I) or a salt thereof; ##STR1## wherein R.sup.1 represents a hydrogen atom, or a substituted or unsubstituted alkanoyl group, R.sup.2 represents an unsubstituted alkanoyl, substituted lower alkanoyl or substituted lower alkyl group, and m represents an integer of 3 to 7, which are useful for the prevention and/or treatment of diseases caused by lipoxygenase-mediated metablites.
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10.发明授权Novel substance KS-619-1, preparation process and pharmaceutical composition 失效新型物质KS-619-1，制备方法和药物组成
公开(公告)号：US4962125A
公开(公告)日：1990-10-09
申请号：US235654
申请日：1988-08-24
CPC分类号： C12P1/06
摘要： A novel physiologically active substance KS-619-1 having a vasodilative activity is produced by culturing Streptomyces californicus ATCC 3312.
摘要翻译： 具有血管扩张活性的新型生理活性物质KS-619-1是通过培养加利福尼亚镰刀菌（Streptomyces californicus）ATCC 3312产生的。
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