公开(公告)号：US20180265461A1

公开(公告)日：2018-09-20

申请号：US15988300

申请日：2018-05-24

申请人： Mitsubishi Chemical Corporation

发明人： Akihiro Goto

IPC分类号： C07C327/06 ,  C07C327/08

CPC分类号： C07C327/06 ,  C07B61/00 ,  C07C327/08 ,  C07C327/22 ,  C07C327/24 ,  C07C327/26 ,  C07C327/32 ,  C07C2601/14 ,  C07D213/70 ,  C07D277/74

摘要： According to the present invention, there is provided a method for producing carboxylic acid thioester, comprising reacting a compound represented by the following formula (I), carboxylic acid and thiol in the presence of a catalyst including at least one Group 2 metal compound. The production method is a production method which is simple in reaction operation, which places a small load on the environment and the human body and which enables carboxylic acid thioester to be catalytically obtained at a high yield even at a normal temperature and a normal pressure (25° C., 1 atm). In the formula (I), R1 and R2 each independently represent a hydrocarbon group having 1 to 20 carbon atoms.

公开(公告)号：US10005860B2

公开(公告)日：2018-06-26

申请号：US15428940

申请日：2017-02-09

申请人： Basell Poliolefine Italia S.r.l.

发明人： Alessandro Mignogna ,  Reynald Chevalier ,  Igor Kashulin ,  Ilya Nifant'ev ,  Giampiero Morini ,  Martin Schneider

IPC分类号： C08F110/06 ,  C07C327/26 ,  C07C327/28 ,  C07C329/10 ,  C07C333/04

CPC分类号： C08F110/06 ,  C07C327/26 ,  C07C327/28 ,  C07C329/10 ,  C07C333/04 ,  C08F4/651 ,  C08F2500/12 ,  C08F2500/15 ,  C08F4/6545

摘要： Catalyst component for the polymerization of olefins comprising Mg, Ti and an electron donor of formula (I) In which X and Y are selected from, R1, and —OR1 and —NR2, B is oxygen or sulphur S is sulphur, R1 is selected from C1-C15 hydrocarbon groups, optionally contain a heteroatom selected from halogen, P, S, N, O and Si, which can be fused together to form one or more cycles, R is hydrogen or R1 and A is a bivalent bridging group with chain length between the two bridging bonds being 1-10 atoms.

公开(公告)号：US20150133544A1

公开(公告)日：2015-05-14

申请号：US14535953

申请日：2014-11-07

申请人： Promentis Pharmaceuticals, Inc.

发明人： Michael Neary ,  James Nieman ,  Steven Tanis ,  Daniel Lawton

IPC分类号： C07C327/34

CPC分类号： C07D277/08 ,  A61K31/165 ,  A61K31/265 ,  A61K31/426 ,  A61K31/513 ,  C07C323/57 ,  C07C323/58 ,  C07C323/59 ,  C07C323/60 ,  C07C327/26 ,  C07C327/32 ,  C07C327/34 ,  C07C329/06 ,  C07D241/08 ,  C07D277/14 ,  C07D327/04

摘要： A novel substituted N-acetyl-L-cysteine (NAC) derivative and methods of using this compound for the treatment of diseases and/or conditions, including but not limited to diseases and/or conditions of, or involving, the Central Nervous System (CNS), including schizophrenia adrenoleukodystrophy, mitochondrial diseases (e.g. Leigh syndrome, Alpers' disease, and MELAS), Huntington's disease, trichotillomania, HIV-associated neurocognitive disorder, hypoxic-ischemic encephalopathy, drug craving, and drug addiction.

摘要翻译： 新型取代的N-乙酰基-L-半胱氨酸（NAC）衍生物和使用该化合物治疗疾病和/或病症的方法，包括但不限于中枢神经系统的疾病和/或病症或涉及中枢神经系统 CNS），包括精神分裂症肾上腺脑白质营养不良，线粒体疾病（例如Leigh综合征，阿尔卑斯病和MELAS），亨廷顿病，头痛性痴呆，HIV相关神经认知障碍，缺氧缺血性脑病，药物渴求和药物成瘾。

公开(公告)号：US20100032620A1

公开(公告)日：2010-02-11

申请号：US12518808

申请日：2007-12-19

申请人： Mineki Hasegawa ,  Masatomi Irisawa

发明人： Mineki Hasegawa ,  Masatomi Irisawa

IPC分类号： C07C321/10 ,  C09K19/32 ,  C09K19/30 ,  C09K19/36 ,  C08F299/04

CPC分类号： C09K19/3087 ,  C07C327/26 ,  C07C327/28 ,  C07C2601/14 ,  C08F220/30 ,  C08F222/1006 ,  C09K19/3861 ,  C09K2019/0448 ,  G02B5/3016 ,  Y10T428/10

摘要： A polymerizable optically active compound of formula (1) has high helical twisting power. When added to a liquid crystal (LC) composition it achieves required helical pitch without largely impairing the physical and optical properties of the LC composition. The compound is suited to be compounded with a LC material, particularly a cholesteric LC material for making an optically anisotropic element excellent in heat resistance, solvent resistance, transparency, optical characteristics, and LC alignment fixing ability. The compound is also useful to form a LC alignment layer, a LC alignment controlling agent, a coating material, a protective film, etc. X1 and X2 each represent a (meth)acryloyloxy group; Y1 and Y2 each represent a single bond, an optionally branched C1-8 alkylene group, an ether linkage, a thioether linkage, —COO—, —OCO—, —OCO—O—, —S—CO—, —CO—S—, an optionally substituted 6-membered ring, an optionally substituted naphthalene ring, or a combination thereof.

摘要翻译： 式（1）的可聚合光学活性化合物具有高的螺旋扭转力。 当添加到液晶（LC）组合物中时，其获得所需的螺距，而不会大大损害LC组合物的物理和光学性质。 该化合物适合与LC材料，特别是用于制备耐热性，耐溶剂性，透明性，光学特性和LC取向定影性优异的光学各向异性元件的胆甾型液晶材料。 该化合物也可用于形成LC取向层，LC取向控制剂，涂料，保护膜等。X1和X2各自表示（甲基）丙烯酰氧基; Y1和Y2各自表示单键，任选支链的C 1-8亚烷基，醚键，硫醚键，-COO-，-OCO-，-OCO-O-，-S-CO-，-CO-S - 任选取代的6元环，任选取代的萘环或其组合。

公开(公告)号：US07030111B2

公开(公告)日：2006-04-18

申请号：US10457029

申请日：2003-06-06

申请人： Takumi Kawabe ,  Hidetaka Kobayashi

发明人： Takumi Kawabe ,  Hidetaka Kobayashi

IPC分类号： A61K31/5375 ,  A61K31/495 ,  C07D265/30 ,  C07D241/04

CPC分类号： C07C327/26 ,  C07C69/76 ,  C07C327/36 ,  C07D213/65 ,  G01N33/5011

摘要： The invention provides compositions and methods to inhibit the cell cycle G2 checkpoint, in particular the DNA-damage-induced G2 checkpoint, in mammalian cells including human cells. Specifically, the invention provides compositions and methods to sensitize cells to DNA-damaging agents by abrogating the cell cycle G2 checkpoint. Compounds of the invention are used to treat proliferative disorders such as cancer. The invention provides compositions and methods for selectively sensitizing G1 checkpoint impaired cancer cells to DNA-damaging agents and treatments.

摘要翻译： 本发明提供抑制哺乳动物细胞（包括人细胞）中的细胞周期G2检查点，特别是DNA损伤诱导的G2检查点的组合物和方法。 具体地，本发明提供了通过废除细胞周期G2检查点来使细胞对DNA损伤剂敏感的组合物和方法。 本发明的化合物用于治疗增殖性疾病如癌症。 本发明提供了选择性地使G1检查点受损的癌细胞对DNA损伤剂和治疗敏感的组合物和方法。

公开(公告)号：US20040170909A1

公开(公告)日：2004-09-02

申请号：US10748424

申请日：2003-12-30

发明人： Nusrallah Jubran ,  Zbigniew Tokarski ,  Kam W. Law ,  Eric Morrison ,  Vytautas Getautis ,  Vygintas Jankauskas

IPC分类号： G03G005/06 ,  C07C255/57

CPC分类号： C07D295/088 ,  C07C255/41 ,  C07C317/22 ,  C07C327/26 ,  C07C2603/18 ,  C07D285/125 ,  G03G5/0612 ,  G03G5/0618 ,  G03G5/062

摘要： Improved organophotoreceptor comprises an electrically conductive substrate and a photoconductive element on the electrically conductive substrate, the photoconductive element comprising: (a) a charge transport material having the formulaX-Z-Xnullwhere X and Xnull are, each independently, a (9-fluorenylidene)malononitrile group, and Z is a linking group; and (b) a charge generating compound. Corresponding electrophotographic apparatuses and imaging methods are described.

摘要翻译： 改进的有机光感受器包括在导电衬底上的导电衬底和光电导元件，光电导元件包括：（a）具有式XZX'的电荷传输材料，其中X和X'各自独立地为（9-亚芴基） 丙二腈基，Z为连接基团; 和（b）电荷产生化合物。 描述相应的电子照相设备和成像方法。

公开(公告)号：US20030102458A1

公开(公告)日：2003-06-05

申请号：US10244404

申请日：2002-09-17

发明人： Naoyuki Nishikawa ,  Kentaro Toyooka

IPC分类号： C09K019/30 ,  C09K019/20

CPC分类号： C07C237/24 ,  C07C62/34 ,  C07C69/757 ,  C07C69/76 ,  C07C235/40 ,  C07C237/42 ,  C07C323/62 ,  C07C327/24 ,  C07C327/26 ,  C07C327/28 ,  C07C2601/04 ,  C07C2601/14 ,  C07D333/20 ,  C07D333/38 ,  Y10T428/10

摘要： A 4-membered compound is represented by the following formula (I) is disclosed (in the formula, X1 and X2 each independently represent an oxygen atom, a sulfur atom or a substituted or unsubstituted imino group, Y1 and Y2 each independently represent a single bond, an oxygen atom or a substituted or unsubstituted imino group, B1 and B2 each independently represent an optionally substituted aliphatic, aliphatic carbonyl, aromatic or aromatic carbonyl group having 1-20 carbon atoms, and A1 and A2 each independently represent a group represented by the following formula (II) (Ar1, Ar2 and Ar3 each independently represent a cyclic group having 5-14 carbon atoms, L1 and L2 each independently represent a single bond or a divalent linking group, and p represents an integer of 0-2)). There is also disclosed a birefringence medium containing a 4-membered compound represented by the formula (I) and an optical element comprising the birefringence medium. 1

摘要翻译： 公开了下式（I）表示的4元化合物（式中，X1和X2各自独立地表示氧原子，硫原子或取代或未取代的亚氨基，Y1和Y2各自独立地表示单 键，氧原子或取代或未取代的亚氨基，B1和B2各自独立地表示具有1-20个碳原子的任选取代的脂族，脂族羰基，芳族或芳族羰基，并且A1和A2各自独立地表示由 下式（II）（Ar1，Ar2和Ar3各自独立地表示具有5-14个碳原子的环状基团，L1和L2各自独立地表示单键或二价连接基团，p表示0-2的整数） ）。 还公开了含有由式（I）表示的4元化合物和包含双折射介质的光学元件的双折射介质。

公开(公告)号：US06201020B1

公开(公告)日：2001-03-13

申请号：US09224294

申请日：1998-12-31

申请人： Jie Zhang ,  Larisa E. Serdyuk ,  Jia-He Li

发明人： Jie Zhang ,  Larisa E. Serdyuk ,  Jia-He Li

IPC分类号： A61K31235

CPC分类号： C07C327/26 ,  C07C69/017

摘要： This invention relates to compounds, pharmaceutical compositions, and methods of using compounds of the formula: A is O or S; R is C1-C10 straight or branched chain alkyl, C2-C10 straight or branched chain alkenyl, C2-C10 straight or branched chain alkynyl, aryl, heteroaryl, carbocycle, or heterocycle; D is a bond, or a C1-C3 straight or branched chain alkyl, C2-C3 straight or branched chain alkenyl, C2-C3 straight or branched chain alkynyl, wherein any of the carbon atoms of said alkyl, alkenyl, or alkynyl of D are optionally replaced with oxygen, nitrogen, or sulfur; and X is aryl, heteroaryl, carbocycle, or heterocycle.

摘要翻译： 本发明涉及化合物，药物组合物和使用下式的化合物的方法：A为O或S; R为C1-C10直链或支链烷基，C2-C10直链或支链烯基，C2-C10直链或支链 链炔基，芳基，杂芳基，碳环或杂环; D是键或C1-C3直链或支链烷基，C2-C3直链或支链烯基，C2-C3直链或支链炔基，其中任何 D的所述烷基，烯基或炔基的碳原子任选被氧，氮或硫取代; 和X是芳基，杂芳基，碳环或杂环。

公开(公告)号：US5770758A

公开(公告)日：1998-06-23

申请号：US770353

申请日：1996-12-20

申请人： Walter Kunz ,  Beat Jau

发明人： Walter Kunz ,  Beat Jau

IPC分类号： C07C323/62 ,  C07C20060101 ,  C07C319/02 ,  C07C319/12 ,  C07C323/33 ,  C07C323/34 ,  C07C323/47 ,  C07C323/49 ,  C07C323/63 ,  C07C323/64 ,  C07C327/26 ,  C07C335/16 ,  C07C335/22 ,  C07D20060101 ,  C07D277/82 ,  C07D285/00 ,  C07D285/01 ,  C07D285/06 ,  C07D285/14 ,  C07D417/04 ,  C07C255/07 ,  C07C321/08 ,  C07C327/16

CPC分类号： C07D285/14 ,  C07C319/02 ,  C07C319/12 ,  C07C323/63 ,  C07C327/26 ,  C07C335/22 ,  C07D277/82

摘要： Compounds of the formula I ##STR1## and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III ##STR2## In the compounds of the formulae I and III: X is halogen, n is 0,1,2 or 3; Z is CN, CO-A or CS-A, A is hydrogen, halogen, OR.sub.1, SR.sub.2 and N(R.sub.3)R.sub.4 ; R.sub.1 to R .sub.4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R.sub.3 and R.sub.4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O,S and/or N. Processes for the preparation of compounds of the formula I are described.

摘要翻译： 式I的化合物及其二硫化物及其盐是制备具有式III的杀微生物和植物免疫作用的化合物的重要的中间产物。在式I和III的化合物中 X为卤素，n为0,1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的 未取代的苄基或苯乙基，取代或未取代的不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。用于制备 描述了式I。

公开(公告)号：US5241108A

公开(公告)日：1993-08-31

申请号：US624009

申请日：1990-12-07

申请人： Gerhard Horpel ,  Karl-Heinz Nordsiek

发明人： Gerhard Horpel ,  Karl-Heinz Nordsiek

IPC分类号： C07C327/36 ,  C07C327/26 ,  C08G75/14 ,  C08K5/36 ,  C08K5/38 ,  C08L21/00

CPC分类号： C08K5/38 ,  C07C327/26 ,  C08G75/14 ,  C08L21/00

摘要： Polysulfide derivatives having the general formula (A--S--S--).sub.2 X--S--S--A, processes for their production and their use for crosslinking of reversion-stable rubber vulcanizates are provided. Crosslinking with reduced reversion and loss of elastomeric properties with age is achieved by the crosslinking system provided by the invention.

摘要翻译： 提供了具有通式（A-S-S-）2 X-S-S-A的多硫化物衍生物及其制备方法及其用于交换回复稳定的橡胶硫化橡胶。 通过本发明提供的交联体系实现了具有降低的回复和随着年龄的弹性体特性损失的交联。