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1.
公开(公告)号:US20040097516A1
公开(公告)日:2004-05-20
申请号:US10664337
申请日:2003-09-17
申请人: Schering Corporation
发明人: Michael P. Dwyer , Timothy J. Guzi , Kamil Paruch , Ronald J. Doll , Kartik M. Keertikar , Viyyoor M. Girijavallabhan
IPC分类号: A61K031/496 , A61K031/4745 , C07D471/02
CPC分类号: C07D471/04
摘要: In its many embodiments, the present invention provides a novel class of pyrazolonull1,5-anullpyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的吡唑并[1,5-a]吡啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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公开(公告)号:US20040209878A1
公开(公告)日:2004-10-21
申请号:US10776988
申请日:2004-02-11
发明人: Timothy J. Guzi , Kamil Paruch , Michael P. Dwyer , Ronald J. Doll , Viyyoor M. Girijavallabhan , Alan Mallams , Carmen S. Alvarez , Kartik M. Keertikar , Jocelyn Rivera , Tin-Yau Chan , Vincent Madison , Thierry O. Fischmann , Lawrence W. Dillard , Vinh D. Tran , Zhen Min He , Ray Anthony James , Haengsoon Park , Vidyadhar M. Paradkar , Douglas Walsh Hobbs
IPC分类号: A61K031/5377 , A61K031/519 , C07D487/04
CPC分类号: C07D487/04 , A61K31/495
摘要: In its many embodiments, the present invention provides a novel class of pyrazolonull1,5-anullpyrimidine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
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3.
公开(公告)号:US20040097517A1
公开(公告)日:2004-05-20
申请号:US10664338
申请日:2003-09-17
申请人: Schering Corporation
发明人: Michael P. Dwyer , Timothy J. Guzi , Kamil Paruch , Ronald J. Doll , Kartik M. Keertikar , Viyyoor M. Girijavallabhan
IPC分类号: C07D471/02 , A61K031/496 , A61K031/4745
CPC分类号: C07D471/04
摘要: In its many embodiments, the present invention provides a novel class of imidazonull1,2-anullpyridine compounds as inhibitors of cyclin dependent kinases, methods of preparing such compounds, pharmaceutical compositions containing one or more such compounds, methods of preparing pharmaceutical formulations comprising one or more such compounds, and methods of treatment, prevention, inhibition, or amelioration of one or more diseases associated with the CDKs using such compounds or pharmaceutical compositions.
摘要翻译: 在其许多实施方案中,本发明提供了一类新颖的咪唑并[1,2-a]吡啶化合物作为细胞周期蛋白依赖性激酶的抑制剂,制备此类化合物的方法,含有一种或多种此类化合物的药物组合物,制备药物制剂的方法 包括一种或多种这样的化合物,以及使用这些化合物或药物组合物治疗,预防,抑制或改善与CDK相关的一种或多种疾病的方法。
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4.
公开(公告)号:US20040122018A1
公开(公告)日:2004-06-24
申请号:US10325896
申请日:2002-12-19
申请人: Schering Corporation
发明人: Hugh Y. Zhu , F. George Njoroge , Alan B. Cooper , Timothy Guzi , Dinanath F. Rane , Keith P. Minor , Ronald J. Doll , Viyyoor M. Girijavallabhan , Bama Santhanam , Patrick A. Pinto , Bancha Vibulbhan , Kartik M. Keertikar , Carmen S. Alvarez , John J. Baldwin , Ge Li , Chia-Yu Huang , Ray A. James , W. Robert Bishop , James J-S Wang , Jagdish A. Desai
IPC分类号: A61K031/496 , A61K031/473 , C07D43/02
CPC分类号: C07D231/12 , C07D221/16 , C07D233/56 , C07D249/08 , C07D401/04 , C07D401/06 , C07D401/14
摘要: Disclosed are novel tricyclic compounds represented by the formula (1.0): 1 and a pharmaceutically acceptable salt or solvate thereof. The compounds are useful for inhibiting farnesyl protein transferase. Also disclosed are pharmaceutical compositions comprising compounds of formula 1.0. Also disclosed are methods of treating cancer using the compounds of formula 1.0.
摘要翻译: 公开了由式(1.0)表示的新型三环化合物及其药学上可接受的盐或溶剂化物。 该化合物可用于抑制法呢基蛋白转移酶。 还公开了含有式1.0化合物的药物组合物。 还公开了使用式1.0化合物治疗癌症的方法。
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