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公开(公告)号：US20090073387A1
公开(公告)日：2009-03-19
申请号：US12207303
申请日：2008-09-09
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译： 评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。 在一个方面，使用上下文信息来补偿或校正测量数据。 在另一方面，重新映射参考坐标以改善比较或可视化。 在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。 在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。 关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。 与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。 这些改进是在比较之前划分规范性数据库或修改测量数据的结果。 关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。
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公开(公告)号：US08128229B2
公开(公告)日：2012-03-06
申请号：US12859727
申请日：2010-08-19
IPC分类号： A61B3/10
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译： 评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。 在一个方面，使用上下文信息来补偿或校正测量数据。 在另一方面，重新映射参考坐标以改善比较或可视化。 在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。 在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。 关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。 与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。 这些改进是在比较之前划分规范性数据库或修改测量数据的结果。 关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。
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公开(公告)号：US20110063573A1
公开(公告)日：2011-03-17
申请号：US12859727
申请日：2010-08-19
IPC分类号： A61B3/00
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译： 评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。 在一个方面，使用上下文信息来补偿或校正测量数据。 在另一方面，重新映射参考坐标以改善比较或可视化。 在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。 在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。 关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。 与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。 这些改进是在比较之前划分规范性数据库或修改测量数据的结果。 关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。
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公开(公告)号：US07798647B2
公开(公告)日：2010-09-21
申请号：US12207303
申请日：2008-09-09
IPC分类号： A61B3/00
CPC分类号： A61B3/12 , A61B3/1241
摘要： One embodiment of the present invention accounts for individual anatomical variation when evaluating optical nerve fiber measurements. In one aspect, contextual information is used to compensate or correct measurement data. In another aspect, reference coordinates are remapped for improved comparison or visualization. In one embodiment of this latter aspect, the method uses measurements of nerve fiber capacity and maps of nerve fiber retinal service to improve sensitivity and specificity in eye function metrics. In one instance, we use the birefringence of nerve fibers to determine the orientation of the fibers within the RNFL. Orientation of the fibers about the ONH is indicative of the service provided by the fibers and is used to improve the interpretation of thickness measurements of the nerve fiber layer. Normalized nerve fiber measurements about the optic nerve head improve specificity and sensitivity as compared to the standard model. These improvements are a result of partitioning the normative database or modifying the measurement data prior to comparison. Statistics on normalized measurements of nerve fiber bundles also show improvements in specificity and sensitivity.
摘要翻译： 评估光学神经纤维测量时，本发明的一个实施例解释了个体解剖学变化。 在一个方面，使用上下文信息来补偿或校正测量数据。 在另一方面，重新映射参考坐标以改善比较或可视化。 在后一方面的一个实施例中，该方法使用神经纤维能力的测量和神经纤维视网膜服务的图来提高眼睛功能度量中的灵敏度和特异性。 在一种情况下，我们使用神经纤维的双折射来确定RNFL内纤维的取向。 关于ONH的纤维的取向指示由纤维提供的服务，并且用于改善对神经纤维层的厚度测量的解释。 与标准模型相比，关于视神经头的规范化神经纤维测量提高了特异性和灵敏度。 这些改进是在比较之前划分规范性数据库或修改测量数据的结果。 关于神经纤维束的归一化测量的统计数据也显示出特异性和灵敏度的改善。
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5.发明申请METHODS, SYSTEMS AND APPLICATIONS OF VARIABLE IMAGING DEPTH IN FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY 审中-公开方法，系统和可变成像深度在FOURIER DOMAIN OPTICAL COHERENCE TOMOGRAPHY中的应用公开(公告)号：US20130120757A1
公开(公告)日：2013-05-16
申请号：US13354066
申请日：2012-01-19
CPC分类号： A61B3/102 , G01B9/02004 , G01B9/02069 , G01B9/02091 , G01N21/4795
摘要： Systems, methods and applications for adjusting the imaging depth of a Fourier Domain optical coherence tomography system without impacting the axial resolution of the system are presented. One embodiment of the invention involves changing the sweep rate of a swept-source OCT system while maintaining the same data acquisition rate and spectral bandwidth of the source. Another embodiment involves changing the data acquisition rate of a SS-OCT system while maintaining the same sweep rate over the same spectral bandwidth. Several applications of variable imaging depth in the field of ophthalmic imaging are described.
摘要翻译： 提出了一种用于调整傅立叶域光学相干断层扫描系统的成像深度而不影响系统轴向分辨率的系统，方法和应用。 本发明的一个实施例涉及改变扫频源OCT系统的扫描速率，同时维持源的相同的数据采集速率和光谱带宽。 另一实施例涉及改变SS-OCT系统的数据采集速率，同时在相同的光谱带宽上保持相同的扫描速率。 描述了眼科成像领域可变成像深度的几种应用。
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公开(公告)号：US07865005B2
公开(公告)日：2011-01-04
申请号：US11627087
申请日：2007-01-25
申请人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
发明人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/408 , G06T2211/424
摘要： In an imaging method, estimated data is iteratively projected and backprojected. The iterative projecting and backprojecting includes projecting or backprojecting the estimated data along parallel paths each employing energy-dependent parameters appropriate for a different energy. During each iteration, the estimated data is adjusted based on comparison of the estimated data with measured data.
摘要翻译： 在成像方法中，估计数据被迭代地投影并反向投影。 迭代投影和反向投影包括沿着并行路径投影或反投影估计数据，每个并行路径采用适用于不同能量的能量相关参数。 在每次迭代期间，基于估计数据与测量数据的比较来调整估计数据。
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公开(公告)号：US20090232375A1
公开(公告)日：2009-09-17
申请号：US12067185
申请日：2006-08-21
申请人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
IPC分类号： G06K9/00
CPC分类号： G01T1/2985 , A61B6/037 , G06T5/002 , G06T11/006 , G06T2207/10081 , G06T2207/10104 , G06T2207/10108 , G06T2207/30004 , G06T2211/424
摘要： An imaging system (10) comprises at least one radiation detector (20) disposed adjacent a subject receiving aperture (18) to detect radiation from a subject, receive the radiation and generate measured data. An image processor (38) iteratively reconstructs the detected radiation into image representations, in each reconstruction iteration the image processor (38) applies noise reduction algorithms to at least a difference between the measured data and a portion of a previous iteration image representation.
摘要翻译： 成像系统（10）包括邻近对象接收孔（18）设置的至少一个辐射检测器（20），以检测来自对象的辐射，接收辐射并产生测量数据。 图像处理器（38）将检测到的辐射重建成图像表示，在每个重建迭代中，图像处理器（38）将噪声降低算法应用于至少测量数据与先前迭代图像表示的一部分之间的差异。
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公开(公告)号：US06664542B2
公开(公告)日：2003-12-16
申请号：US10026381
申请日：2001-12-20
申请人： Jinghan Ye , Lingxiong Shao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Mary K. Durbin
IPC分类号： G01T1166
CPC分类号： G01T1/1648
摘要： A gamma camera system and method are described which use multiple point sources to detect inaccuracies in detector translational and rotational alignment. In practice of the method of the preferred embodiment, three capillary tubes, each containing a drop of an isotope, are located in different planes and locations with respect to the axis of rotation of the detectors. A SPECT acquisition is performed and the point source projection data is processed to calculate the point source coordinates, from which center-of-rotation correction factors may be calculated. These correction factors are applied by mechanical and software adjustments to the gantry and acquisition systems of the camera to correct for both translational and rotational inaccuracies.
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公开(公告)号：US08208599B2
公开(公告)日：2012-06-26
申请号：US12067185
申请日：2006-08-21
申请人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
发明人： Jinghan Ye , Lingxiong Shao , Zuo Zhao , Mary K. Durbin
IPC分类号： G06K9/00
CPC分类号： G01T1/2985 , A61B6/037 , G06T5/002 , G06T11/006 , G06T2207/10081 , G06T2207/10104 , G06T2207/10108 , G06T2207/30004 , G06T2211/424
摘要： An imaging system (10) comprises at least one radiation detector (20) disposed adjacent a subject receiving aperture (18) to detect radiation from a subject, receive the radiation and generate measured data. An image processor (38) iteratively reconstructs the detected radiation into image representations, in each reconstruction iteration the image processor (38) applies noise reduction algorithms to at least a difference between the measured data and a portion of a previous iteration image representation.
摘要翻译： 成像系统（10）包括邻近对象接收孔（18）设置的至少一个辐射检测器（20），以检测来自对象的辐射，接收辐射并产生测量数据。 图像处理器（38）将检测到的辐射重建成图像表示，在每个重建迭代中，图像处理器（38）将噪声降低算法应用于至少测量数据与先前迭代图像表示的一部分之间的差异。
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公开(公告)号：US20070183642A1
公开(公告)日：2007-08-09
申请号：US11627087
申请日：2007-01-25
申请人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
发明人： Jinghan Ye , Mary K. Durbin , Xiyun Song , Lingxiong Shao
IPC分类号： G06K9/00
CPC分类号： G06T11/006 , G06T2211/408 , G06T2211/424
摘要： In an imaging method, estimated data is iteratively projected and backprojected. The iterative projecting and backprojecting includes projecting or backprojecting the estimated data along parallel paths each employing energy-dependent parameters appropriate for a different energy. During each iteration, the estimated data is adjusted based on comparison of the estimated data with measured data.
摘要翻译： 在成像方法中，估计数据被迭代地投影并反向投影。 迭代投影和反向投影包括沿着并行路径投影或反投影估计数据，每个并行路径采用适用于不同能量的能量相关参数。 在每次迭代期间，基于估计数据与测量数据的比较来调整估计数据。
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