公开(公告)号：US07910151B2

公开(公告)日：2011-03-22

申请号：US11260526

申请日：2005-10-27

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： A61L33/00

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法及其制造方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 控制释放系统可以结合到可植入药物递送或生物传感装置中。

公开(公告)号：US07510551B2

公开(公告)日：2009-03-31

申请号：US10641507

申请日：2003-08-15

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 在一个实施方案中，将控制释放系统结合到可植入药物递送装置中。

公开(公告)号：US07455667B2

公开(公告)日：2008-11-25

申请号：US11259301

申请日：2005-10-26

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard, Jr. ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： A61K9/22

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods are provided for the controlled release or exposure of reservoir contents. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. In one embodiment, the controlled release system is incorporated into an implantable drug delivery device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 在一个实施方案中，将控制释放系统结合到可植入药物递送装置中。

公开(公告)号：US20080168921A1

公开(公告)日：2008-07-17

申请号：US11260526

申请日：2005-10-27

申请人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard ,  Stephen J. Herman ,  Barry Y. Yomtov

发明人： Scott A. Uhland ,  Benjamin F. Polito ,  John M. Maloney ,  Norman F. Sheppard ,  Stephen J. Herman ,  Barry Y. Yomtov

IPC分类号： C23C18/44

CPC分类号： A61M25/0082 ,  A61B5/0215 ,  A61B5/042 ,  A61B5/1459 ,  A61B5/1473 ,  A61B5/4839 ,  A61M5/14276 ,  A61M25/0069 ,  A61M37/00 ,  A61M2005/1726 ,  A61M2205/0244 ,  A61M2205/123 ,  A61M2205/3653 ,  A61N1/32 ,  Y10T436/25

摘要： Devices and methods for the controlled release or exposure of reservoir contents, and methods of manufacture thereof, are provided. The device includes a reservoir cap formed of an electrically conductive material, which prevents the reservoir contents from passing out from the device and prevents exposure of the reservoir contents to molecules outside of the device; an electrical input lead connected to said reservoir cap; and an electrical output lead connected to said reservoir cap, such that upon application of an electrical current through the reservoir cap, via the input lead and output lead, the reservoir cap ruptures to release or expose the reservoir contents. The reservoir contents can comprise a release system containing drug molecules for release or can comprise a secondary device, such as a sensor. The controlled release system may be incorporated into an implantable drug delivery or biosensing device.

摘要翻译： 提供了用于控制释放或暴露储存器内容物的装置和方法及其制造方法。 该装置包括由导电材料形成的储存器盖，其防止储存器内容物从装置中流出并防止储存器内容物暴露于装置外部的分子; 连接到所述储存器盖的电输入引线; 以及连接到所述储存器盖的电输出引线，使得当经由所述输入引线和输出引线施加电流通过所述储存器盖时，所述储存器盖破裂以释放或暴露所述储存器内容物。 储存器内容物可以包含含有用于释放的药物分子的释放系统，或者可以包括次级装置，例如传感器。 控制释放系统可以结合到可植入药物递送或生物传感装置中。