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公开(公告)号：US06444809B1
公开(公告)日：2002-09-03
申请号：US09668257
申请日：2000-09-22
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: C07D40104
CPC classification number: C07D401/04 , C07D413/04
Abstract: Compounds of formula I wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: G，J，L，M，m和D中的式I化合物具有说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐是神经激肽A的非肽拮抗剂，可用于治疗哮喘等 还公开了药物组合物，制备式I化合物的方法和中间体。
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公开(公告)号：US5990130A
公开(公告)日：1999-11-23
申请号：US106606
申请日：1998-06-29
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/535 , A61K31/5355 , A61K31/55 , A61K31/551 , A61P11/00 , A61P11/06 , A61P43/00 , C07D401/04 , C07D413/04 , C07D413/14 , C07D417/04
CPC classification number: C07D401/04 , C07D413/04
Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
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公开(公告)号：US5977135A
公开(公告)日：1999-11-02
申请号：US89019
申请日：1998-06-02
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/517 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/00 , A61P29/00 , A61P43/00 , C07D401/04 , A61K31/47 , C07D217/22
CPC classification number: C07D401/04
Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: 其中Q1，m和M具有本说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐的式I化合物是神经激肽A的非肽拮抗剂，可用于治疗哮喘等。还公开了药物 组合物，制备式I化合物的方法和中间体。
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公开(公告)号：US5965576A
公开(公告)日：1999-10-12
申请号：US980399
申请日：1997-11-26
Applicant: Ashokkumar Bhikkappa Shenvi , Robert Toms Jacobs , Scott Carson Miller , Cyrus John Ohnmacht, Jr. , Chris Allan Veale
Inventor： Ashokkumar Bhikkappa Shenvi , Robert Toms Jacobs , Scott Carson Miller , Cyrus John Ohnmacht, Jr. , Chris Allan Veale
IPC: A61K31/40 , A61P11/00 , C07D401/06 , C07D401/14 , A61K31/445
CPC classification number: C07D401/06 , C07D401/14
Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: 其中Q1，Q2，Q3和Q4具有本说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐的式I化合物是神经激肽A的非肽拮抗剂，可用于治疗哮喘等。另外 公开的是药物组合物，制备式I化合物的方法和中间体。
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公开(公告)号：US6124279A
公开(公告)日：2000-09-26
申请号：US336087
申请日：1999-06-18
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/535 , A61K31/5355 , A61K31/55 , A61K31/551 , A61P11/00 , A61P11/06 , A61P43/00 , C07D401/04 , C07D413/04 , C07D413/14 , A61K31/553 , C07D413/02
CPC classification number: C07D401/04 , C07D413/04
Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: 其中G，J，L，M，m和D具有本说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐的式I化合物是神经激肽A的非肽拮抗剂，可用于治疗哮喘， 还公开了药物组合物，制备式I化合物和中间体的方法。
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Patent Agency Ranking6.发明授权Substituted piperidinobutyl nitrogen-containing heterocyclic compounds and analogues thereof as neurokinin antagonists 失效取代的哌啶丁基含氮杂环化合物及其类似物作为神经激肽拮抗剂
公开(公告)号：US5739149A
公开(公告)日：1998-04-14
申请号：US790867
申请日：1997-02-03
Applicant: Robert Toms Jacobs , Scott Carson Miller , Ashokkumar Bhikkappa Shenvi , Cyrus John Ohnmacht, Jr. , Chris Allan Veale
Inventor： Robert Toms Jacobs , Scott Carson Miller , Ashokkumar Bhikkappa Shenvi , Cyrus John Ohnmacht, Jr. , Chris Allan Veale
IPC: A61K31/4427 , A61K31/445 , A61K31/505 , A61P11/00 , A61P11/06 , A61P43/00 , C07D401/06 , C07D401/14 , C07D401/04
CPC classification number: C07D401/06 , C07D401/14
Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: 式I的化合物其中Q1，Q2，Q3和Q4具有本说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐是神经激肽A的非肽拮抗剂，可用于治疗 哮喘等。还公开了药物组合物，制备式I化合物的方法和中间体。
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公开(公告)号：US07053213B2
公开(公告)日：2006-05-30
申请号：US10233160
申请日：2002-08-30
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: C07D413/04 , C07D239/02 , C07D419/04
CPC classification number: C07D401/04 , C07D413/04
Abstract: Pharmaceutical compositions containing novel therapeutic heterocycles for use in diseases in which an NK2 receptor is implicated, processes for preparing and methods for using the same.
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公开(公告)号：US5861392A
公开(公告)日：1999-01-19
申请号：US689199
申请日：1996-08-05
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: A61K31/4427 , A61K31/445 , A61K31/454 , A61K31/505 , A61K31/506 , A61K31/513 , A61K31/535 , A61K31/5355 , A61K31/55 , A61K31/551 , A61P11/00 , A61P11/06 , A61P43/00 , C07D401/04 , C07D413/04 , C07D413/14 , A61K31/54 , A61K31/42
CPC classification number: C07D401/04 , C07D413/04
Abstract: Compounds of formula I ##STR1## wherein G, J, L, M, m and D have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: 式I的化合物其中G，J，L，M，m和D具有本说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐是神经激肽A的非肽拮抗剂， 用于治疗哮喘等。还公开了药物组合物，制备式I化合物的方法和中间体。
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公开(公告)号：US5705505A
公开(公告)日：1998-01-06
申请号：US717999
申请日：1996-09-26
Applicant: Ashokkumar Bhikkappa Shenvi , Robert Toms Jacobs , Scott Carson Miller , Cyrus John Ohnmacht, Jr. , Chris Allan Veale
Inventor： Ashokkumar Bhikkappa Shenvi , Robert Toms Jacobs , Scott Carson Miller , Cyrus John Ohnmacht, Jr. , Chris Allan Veale
IPC: A61K31/40 , A61P11/00 , C07D401/06 , C07D401/14 , A61K31/47 , C07D217/24
CPC classification number: C07D401/06 , C07D401/14
Abstract: Compounds of formula I ##STR1## wherein Q.sup.1, Q.sup.2, Q.sup.3, and Q.sup.4 have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
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公开(公告)号：US5677317A
公开(公告)日：1997-10-14
申请号：US629299
申请日：1996-04-08
Applicant: Scott Carson Miller
Inventor： Scott Carson Miller
IPC: A61K31/4427 , A61K31/445 , A61K31/4468 , A61K31/4545 , A61K31/505 , A61K31/506 , A61P11/00 , A61P11/06 , A61P43/00 , C07D211/76 , C07D401/04 , C07D401/06 , C07D403/04 , C07D403/06 , C07D413/12
CPC classification number: C07D401/04 , C07D211/76 , C07D403/04 , Y10S514/826
Abstract: Compounds of formula I ##STR1## wherein J, B, L, X, m and M have any of the meanings given in the specification, their N-oxides, and their pharmaceutically acceptable salts are nonpeptide antagonists of neurokinin A and useful for the treatment of asthma, etc. Also disclosed are pharmaceutical compositions, processes for preparing the compounds of formula I and intermediates.
Abstract translation: 式I的化合物其中J，B，L，X，m和M具有本说明书中给出的任何含义，其N-氧化物及其药学上可接受的盐是神经激肽A的非肽拮抗剂和有用的 用于治疗哮喘等。还公开了药物组合物，制备式I化合物的方法和中间体。
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