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公开(公告)号:US20130302355A1
公开(公告)日:2013-11-14
申请号:US13819935
申请日:2011-09-02
IPC分类号: C07K16/18
CPC分类号: C07K16/18 , A61K39/3955 , A61K39/39558 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyper-proliferative disorders are provided.
摘要翻译: 提供了新型调节剂,包括抗体及其衍生物,以及使用这种调节剂治疗高增殖性疾病的方法。
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公开(公告)号:US09458231B2
公开(公告)日:2016-10-04
申请号:US13819935
申请日:2011-09-02
CPC分类号: C07K16/18 , A61K39/3955 , A61K39/39558 , A61K47/6825 , A61K47/6849 , A61K47/6851 , A61K2039/505 , C07K16/2896 , C07K16/30 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , A61K2300/00
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
摘要翻译: 提供了新型调节剂,包括抗体及其衍生物,以及使用这些调节剂治疗过度增殖性疾病的方法。
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公开(公告)号:US09320812B2
公开(公告)日:2016-04-26
申请号:US13992599
申请日:2011-12-07
申请人: Johannes Hampl , Scott J. Dylla , Orit Foord , Robert A. Stull
发明人: Johannes Hampl , Scott J. Dylla , Orit Foord , Robert A. Stull
CPC分类号: C07K16/18 , A61K38/47 , A61K47/64 , A61K47/6455 , A61K47/6811 , A61K47/6815 , A61K47/6855 , A61K47/6867 , A61K47/6869 , A61K47/6891 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Y302/02022 , G01N33/574
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
摘要翻译: 提供了新型调节剂,包括抗体及其衍生物,以及这些调节剂治疗过度增殖性疾病的方法。
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公开(公告)号:US20140105888A1
公开(公告)日:2014-04-17
申请号:US14000289
申请日:2012-02-17
申请人: Orit Foord , Scott J. Dylla , Robert A. Stull , Alex Bankovich , Alexandra Leida Liana Lazetic , Jeffrey Bernstein
发明人: Orit Foord , Scott J. Dylla , Robert A. Stull , Alex Bankovich , Alexandra Leida Liana Lazetic , Jeffrey Bernstein
CPC分类号: C07K16/32 , A61K47/6803 , A61K47/6851 , C07K16/30 , C07K16/40 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N2740/15043
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
摘要翻译: 提供了新型调节剂,包括抗体及其衍生物,以及使用这些调节剂治疗过度增殖性疾病的方法。
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公开(公告)号:US09409995B2
公开(公告)日:2016-08-09
申请号:US14000289
申请日:2012-02-17
申请人: Orit Foord , Scott J. Dylla , Robert A. Stull , Alex Bankovich , Alexandra Leida Liana Lazetic , Jeffrey Bernstein
发明人: Orit Foord , Scott J. Dylla , Robert A. Stull , Alex Bankovich , Alexandra Leida Liana Lazetic , Jeffrey Bernstein
IPC分类号: C07K16/40 , A61K39/395 , C07K16/30 , A61K47/48
CPC分类号: C07K16/32 , A61K47/6803 , A61K47/6851 , C07K16/30 , C07K16/40 , C07K2317/24 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/92 , C12N2740/15043
摘要: PTK modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyper-proliferative disorders are provided.
摘要翻译: 提供PTK调节剂,包括抗体及其衍生物,以及使用这些调节剂治疗高增殖性疾病的方法。
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公开(公告)号:US20140093495A1
公开(公告)日:2014-04-03
申请号:US13992599
申请日:2011-12-07
申请人: Johannes Hampl , Scott J. Dylla , Orit Foord , Robert A. Stull
发明人: Johannes Hampl , Scott J. Dylla , Orit Foord , Robert A. Stull
IPC分类号: C07K16/40
CPC分类号: C07K16/18 , A61K38/47 , A61K47/64 , A61K47/6455 , A61K47/6811 , A61K47/6815 , A61K47/6855 , A61K47/6867 , A61K47/6869 , A61K47/6891 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Y302/02022 , G01N33/574
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of such modulators to treat hyperproliferative disorders are provided.
摘要翻译: 提供了新型调节剂,包括抗体及其衍生物,以及这些调节剂治疗过度增殖性疾病的方法。
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公开(公告)号:US20130224191A1
公开(公告)日:2013-08-29
申请号:US13819208
申请日:2011-08-26
申请人: Robert A. Stull , Scott J. Dylla , Orit Foord , Monette Aujay
发明人: Robert A. Stull , Scott J. Dylla , Orit Foord , Monette Aujay
CPC分类号: C07K16/40 , C07K16/18 , C07K2317/24 , C07K2317/33 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/92 , C07K2319/30 , C12N9/14 , G01N33/6893
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
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公开(公告)号:US20130058947A1
公开(公告)日:2013-03-07
申请号:US13369275
申请日:2012-02-08
申请人: Robert A. Stull , Monette Aujay , Orit Foord , Alex Bankovich , Johannes Hampl , Scott J. Dylla
发明人: Robert A. Stull , Monette Aujay , Orit Foord , Alex Bankovich , Johannes Hampl , Scott J. Dylla
IPC分类号: A61K39/395 , C07H21/04 , A61P35/00 , C07K16/28
CPC分类号: C07K16/2896 , A61K2039/505 , C07K2317/24 , C07K2317/33 , C07K2317/55 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat proliferative disorders are provided.
摘要翻译: 提供了新型调节剂,包括抗体及其衍生物,以及使用这些调节剂治疗增殖性疾病的方法。
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公开(公告)号:US20140302034A1
公开(公告)日:2014-10-09
申请号:US13995086
申请日:2011-12-07
申请人: Alex Bankovich , Orit Foord , Johannes Hampl , Scott J. Dylla
发明人: Alex Bankovich , Orit Foord , Johannes Hampl , Scott J. Dylla
CPC分类号: C07K16/18 , A61K38/47 , A61K47/64 , A61K47/6455 , A61K47/6811 , A61K47/6815 , A61K47/6855 , A61K47/6867 , A61K47/6869 , A61K47/6891 , C07K16/28 , C07K16/2809 , C07K16/2896 , C07K16/30 , C07K16/3015 , C07K16/3061 , C07K16/3069 , C07K16/40 , C07K2317/14 , C07K2317/24 , C07K2317/33 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12Y302/02022 , G01N33/574
摘要: Novel modulators, including antibodies and derivatives thereof, and methods of using such modulators to treat hyperproliferative disorders are provided.
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10.
公开(公告)号:US09062113B2
公开(公告)日:2015-06-23
申请号:US12268363
申请日:2008-11-10
申请人: Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
发明人: Richard Weber , Xiao Feng , Orit Foord , Larry Green , Jean Gudas , Bruce Keyt , Ying Liu , Palaniswami Rathanaswami , Robert Raya , Xiao Dong Yang , Jose Corvalan , Ian Foltz , Xiao-Chi Jia , Jaspal S. Kang , Chadwick T. King , Scott L. Klakamp , Qiaojuan Jane Su
CPC分类号: C07K16/30 , A61K47/6803 , A61K47/6849 , A61K47/6897 , A61K2039/505 , B82Y5/00 , C07K16/2863 , C07K2317/21 , C07K2317/34 , C07K2317/77 , C07K2317/92 , Y10S435/81
摘要: The present invention relates to novel antibodies, particularly antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to the type III deletion mutant, EGFRvIII. The invention also relates to human monoclonal antibodies directed against deletion mutants of epidermal growth factor receptor and particularly to EGFRvIII. Diagnostic and therapeutic formulations of such antibodies, and immunoconjugates thereof, are also provided.
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