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    Collagen density and structural change measurement and mapping in tissue
    9.
    发明授权
    Collagen density and structural change measurement and mapping in tissue 有权
    胶原密度和组织结构变化测量和绘图

    公开(公告)号：US08047990B2

    公开(公告)日：2011-11-01

    申请号：US11656315

    申请日：2007-01-19

    申请人： Everette C. Burdette ,  Scott P. Huntley

    发明人： Everette C. Burdette ,  Scott P. Huntley

    IPC分类号： A61B8/00

    CPC分类号： G01S7/52071 ,  A61B8/08 ,  G06T7/0012 ,  G06T2207/10132 ,  G06T2207/30024

    摘要： A method and system for two and three dimensional mapping of tissue density and/or structural changes from image data and/or spatial reflected or transmitted signal maps, and correlating the maps to changes in collagen density. The method and system includes the steps of: receiving an image or spatial maps of acoustic-derived RF signal data from tissue comprised of multiple pixels, segregating the image into groups of pixels, each group of pixels having characteristics within a defined class, establishing a baseline set of classes corresponding to initial conditions of the imaged/mapped tissue, measuring a differential in the set of classes for a group of pixels, the differential corresponding to a change in pixel values for the group of pixels, correlating said measured differential to a density change for the tissue corresponding to the group of pixels, and overlaying an indication of collagen density over the tissue image or mapped signal responses correlated with thermal dose indicating a change in collagen density for the tissue.

    摘要翻译： 一种用于从图像数据和/或空间反射或发射信号图中组织密度和/或结构变化的二维和三维映射的方法和系统，并且将该图与胶原密度变化相关联。 所述方法和系统包括以下步骤：从由多个像素组成的组织接收声学导出的RF信号数据的图像或空间图，将图像分离成像素组，每组像素具有在限定类别内的特征，建立 对应于成像/映射组织的初始条件的类的基准集合，测量一组像素的类的集合中的差分，所述差异对应于所述像素组的像素值的变化，将所述测量的差分与 对应于该组像素的组织的密度变化，并且覆盖组织图像上的胶原密度的指示或与表示组织的胶原密度变化的热剂量相关的映射信号响应。

    Monitoring of total ammoniacal concentration in blood
    10.
    发明授权
    Monitoring of total ammoniacal concentration in blood 失效
    监测血液中总氨浓度

    公开(公告)号：US06219567B1

    公开(公告)日：2001-04-17

    申请号：US09337382

    申请日：1999-06-21

    申请人： Philip E. Eggers ,  Andrew R. Eggers ,  Eric A. Eggers ,  Scott P. Huntley

    发明人： Philip E. Eggers ,  Andrew R. Eggers ,  Eric A. Eggers ,  Scott P. Huntley

    IPC分类号： A61B500

    CPC分类号： A61B5/14542 ,  A61B5/14539 ,  A61B5/1473 ,  A61B5/412 ,  G01N33/84

    摘要： Total ammoniacal concentration (TAC) in blood is measured and displayed on a repetitive basis by a controller driven sensor arrangement which may be utilized either with a catheter structure or with a bypass system. The catheter based sensors may be employed with a peripheral region of the vascular system of the body. Repetitive measurements are carried out and these measurements are subjected to a moving average filtering procedure, whereupon the filtered TAC values are displayed numerically and graphically. The controller functions to compute the rate-of-rise of TAC and compares that value with a threshold rate-of-rise valuation which is inputted by the practitioner. Threshold values for TAC also may be inputted and the system not only provides alarm warnings for threshold excursions in TAC above threshold or excursions in rate-of-rise of TAC above threshold but also provides a visual cuing as a warning that TAC is elevating from one filtered measurement to the next.

    摘要翻译： 通过控制器驱动的传感器装置测量和显示血液中的总氨基酸浓度（TAC），其可以重复地显示，其可以与导管结构或旁路系统一起使用。 基于导管的传感器可以与身体的血管系统的周边区域一起使用。 进行重复测量，并对这些测量进行移动平均滤波过程，然后以数字和图形方式显示经过滤的TAC值。 控制器用于计算TAC的升率，并将该值与从业者输入的阈值上升率估值进行比较。 TAC的阈值也可以被输入，并且系统不仅提供TAC中阈值偏差的警报警报，或者超过阈值的TAC的上升速率的偏移量，还提供视觉检测作为TAC从一个升高的警告 过滤测量到下一个。