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1.发明申请ZCYTOR19 HETERODIMERIC CYTOKINE RECEPTOR POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS 审中-公开ZCYTOR19高分子细胞因子受体多核苷酸，多肽，抗体和方法公开(公告)号：US20110171627A1
公开(公告)日：2011-07-14
申请号：US12723364
申请日：2010-03-12
申请人： Scott R. Presnell , Francis J. Grant , Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
发明人： Scott R. Presnell , Francis J. Grant , Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
CPC分类号： C07K14/7155
摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了与IL-28R和CRF2-4形成异二聚体受体复合物的新方法。 该方法可用于体外和体内检测和治疗病毒感染。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 本发明还包括生产蛋白质的方法，用途及其抗体。
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2.发明申请ZCYTOR19 HETERODIMERIC CYTOKINE RECEPTOR POLYNUCLEOTIDES, POLYPEPTIDES, ANTIBODIES AND METHODS 审中-公开ZCYTOR19高分子细胞因子受体多核苷酸，多肽，抗体和方法公开(公告)号：US20120053321A1
公开(公告)日：2012-03-01
申请号：US13252723
申请日：2011-10-04
申请人： Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
发明人： Wenfeng Xu , Stacy Schlutsmeyer , Cameron S. Brandt , Wayne R. Kindsvogel , Katherine E. Henderson , Theodore E. Whitmore , Kevin M. Klucher
CPC分类号： C07K14/7155
摘要： Novel methods are disclosed for forming a heterodimeric receptor complex with IL-28R and CRF2-4. The methods may be used for detecting and treating viral infections in in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.
摘要翻译： 公开了与IL-28R和CRF2-4形成异二聚体受体复合物的新方法。 该方法可用于体外和体内检测和治疗病毒感染。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 本发明还包括生产蛋白质的方法，用途及其抗体。
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公开(公告)号：US20130273000A1
公开(公告)日：2013-10-17
申请号：US13616688
申请日：2012-09-14
IPC分类号： A61K47/48
CPC分类号： A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。
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公开(公告)号：US20130022571A1
公开(公告)日：2013-01-24
申请号：US13606176
申请日：2012-09-07
CPC分类号： A61K38/20 , A61K38/21 , A61K38/212 , A61K38/57 , A61K47/60 , C07K14/54 , A61K2300/00
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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5.发明授权Methods for treating viral infection using IL-28 and IL-29 cysteine mutants 有权使用IL-28和IL-29半胱氨酸突变体治疗病毒感染的方法公开(公告)号：US08816053B2
公开(公告)日：2014-08-26
申请号：US13606176
申请日：2012-09-07
IPC分类号： C07K14/00
CPC分类号： A61K38/20 , A61K38/21 , A61K38/212 , A61K38/57 , A61K47/60 , C07K14/54 , A61K2300/00
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。
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6.发明申请Methods for treating viral infection using IL-28 and IL-29 Cysteine mutants 有权使用IL-28和IL-29半胱氨酸突变体治疗病毒感染的方法公开(公告)号：US20110300101A1
公开(公告)日：2011-12-08
申请号：US13190628
申请日：2011-07-26
CPC分类号： A61K38/20 , A61K38/21 , A61K38/212 , A61K38/57 , A61K47/60 , C07K14/54 , A61K2300/00
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。
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公开(公告)号：US20090263352A1
公开(公告)日：2009-10-22
申请号：US12470336
申请日：2009-05-21
CPC分类号： A61K38/20 , A61K38/21 , A61K38/212 , A61K38/57 , A61K47/60 , C07K14/54 , A61K2300/00
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
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8.发明申请METHODS FOR TREATING VIRAL INFECTION USING IL-28 AND IL-29 CYSTEINE MUTANTS 审中-公开用于治疗使用IL-28和IL-29 CYSTEINE MUTANT的病毒感染的方法公开(公告)号：US20090018080A1
公开(公告)日：2009-01-15
申请号：US12185694
申请日：2008-08-04
IPC分类号： A61K38/16
CPC分类号： A61K38/20 , A61K38/21 , A61K38/212 , A61K38/57 , A61K47/60 , C07K14/54 , A61K2300/00
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。
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公开(公告)号：US08318147B2
公开(公告)日：2012-11-27
申请号：US13225741
申请日：2011-09-06
CPC分类号： A61K47/48215 , A61K38/20 , A61K38/21 , A61K47/60 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。
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公开(公告)号：US20100297068A1
公开(公告)日：2010-11-25
申请号：US12608840
申请日：2009-10-29
CPC分类号： A61K47/60 , A61K38/20 , A61K38/21 , C07K14/54 , Y02A50/385 , Y02A50/393
摘要： IL-28A, IL-28B, IL-29, and certain mutants thereof have been shown to have antiviral activity on a spectrum of viral species. Of particular interest is the antiviral activity demonstrated on viruses that infect liver, such as hepatitis B virus and hepatitis C virus. In addition, IL-28A, IL-28B, IL-29, and mutants thereof do not exhibit some of the antiproliferative activity on hematopoietic cells that is observed with interferon treatment. Without the immunosuppressive effects accompanying interferon treatment, IL-28A, IL-28B, and IL-29 will be useful in treating immunocompromised patients for viral infections.
摘要翻译： 已经显示IL-28A，IL-28B，IL-29及其某些突变体对病毒物种的光谱具有抗病毒活性。 特别感兴趣的是在感染肝脏的病毒（例如乙型肝炎病毒和丙型肝炎病毒）上显示的抗病毒活性。 此外，IL-28A，IL-28B，IL-29及其突变体在用干扰素治疗观察到的造血细胞上不表现出一些抗增殖活性。 没有伴随干扰素治疗的免疫抑制作用，IL-28A，IL-28B和IL-29可用于治疗免疫功能低下的病毒感染患者。
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