公开(公告)号：US20120064571A1

公开(公告)日：2012-03-15

申请号：US13267430

申请日：2011-10-06

申请人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

发明人： Scott R. Presnell ,  Francis J. Grant ,  Emily C. Costerison ,  Theodore E. Whitmore

IPC分类号： C12P21/02 ,  C12N15/63 ,  C12N5/10 ,  C07H21/00

CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US20110091876A1

公开(公告)日：2011-04-21

申请号：US12756985

申请日：2010-04-08

申请人： Scott R. Presnell ,  Francis J. Grant ,  Wenfeng Xu ,  Emily C. Costerison ,  Theodore E. Whitmore

发明人： Scott R. Presnell ,  Francis J. Grant ,  Wenfeng Xu ,  Emily C. Costerison ,  Theodore E. Whitmore

IPC分类号： C12Q1/68 ,  C07H21/04 ,  C12N15/63 ,  C12N5/10 ,  C12P21/02 ,  C12P21/00 ,  C07K14/00 ,  C07K16/18 ,  G01N33/53

CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。

公开(公告)号：US07608452B2

公开(公告)日：2009-10-27

申请号：US11539064

申请日：2006-10-05

申请人： Scott R. Presnell ,  Theodore E. Whitmore ,  Francis J. Grant ,  Emily C. Costerison

发明人： Scott R. Presnell ,  Theodore E. Whitmore ,  Francis J. Grant ,  Emily C. Costerison

IPC分类号： C12N5/10 ,  C12N15/10 ,  C12N15/12 ,  C07K14/715

CPC分类号： C07K14/47 ,  C07K14/715 ,  C07K2319/00 ,  Y10T436/143333

摘要： Novel polypeptides, polynucleotides encoding the polypeptides, and related compositions and methods are disclosed for zcytor19, a novel class II cytokine receptor. The polypeptides may be used within methods for detecting ligands that stimulate the proliferation and/or development of hematopoietic, lymphoid and myeloid cells in vitro and in vivo. Ligand-binding receptor polypeptides can also be used to block ligand activity in vitro and in vivo. The polynucleotides encoding zcytor19, are located on chromosome 1p36.11, and can be used to identify a region of the genome associated with human disease states. The present invention also includes methods for producing the protein, uses therefor and antibodies thereto.

摘要翻译： 公开了新型多肽，编码多肽的多核苷酸，以及相关的组合物和方法，用于zcytor19，一种新型的II类细胞因子受体。 多肽可用于检测在体外和体内刺激造血，淋巴和骨髓细胞增殖和/或发育的配体的方法。 配体结合受体多肽也可用于在体外和体内阻断配体活性。 编码zcytor19的多核苷酸位于染色体1p36.11上，可用于鉴定与人类疾病状态相关的基因组区域。 本发明还包括生产蛋白质的方法，用途及其抗体。