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公开(公告)号：US20080160035A1
公开(公告)日：2008-07-03
申请号：US11906517
申请日：2007-10-02
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Dina M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Dina M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： A61K39/395 , C07K16/18 , C12N15/00 , A61P1/00 , A61P17/00 , A61P19/00 , A61P9/00 , C12N5/06 , C12P21/04
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance.
摘要翻译： 通过表面等离振子共振测量的分离的人抗体或其抗体片段，其结合人白细胞介素-4受体α（hIL-4Ralpha）具有小于200pM的亲和常数（K SUB）。
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公开(公告)号：US07794717B2
公开(公告)日：2010-09-14
申请号：US12554029
申请日：2009-09-04
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
摘要翻译： 本发明提供了治疗一种或多种通过降低白细胞介素-4（IL-4）活性而改善，抑制或改善的疾病或病症的方法。 本发明的方法包括向患者施用特异性结合人IL-4受体的抗体或其抗原结合片段。
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公开(公告)号：US20100021476A1
公开(公告)日：2010-01-28
申请号：US12554029
申请日：2009-09-04
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： A61K39/395 , A61P11/06 , A61P17/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
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公开(公告)号：US08092802B2
公开(公告)日：2012-01-10
申请号：US12821499
申请日：2010-06-23
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： A61K39/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
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公开(公告)号：US08338135B2
公开(公告)日：2012-12-25
申请号：US13309594
申请日：2011-12-02
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： C12P21/08
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance, is provided.
摘要翻译： 提供了通过表面等离振子共振测量的以小于200pM的亲和常数（KD）结合人白细胞介素-4受体α（hIL-4Rα）的分离的人抗体或其抗原结合片段。
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公开(公告)号：US20100291107A1
公开(公告)日：2010-11-18
申请号：US12821499
申请日：2010-06-23
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： A61K39/395 , A61P17/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： The present invention provides methods for treating one or more diseases or disorders which are improved, inhibited or ameliorated by reducing interleukin-4 (IL-4) activity. The methods of the invention comprise administering to a patient an antibody, or antigen-binding fragment thereof, which specifically binds to a human IL-4 receptor.
摘要翻译： 本发明提供了治疗一种或多种通过降低白细胞介素-4（IL-4）活性而改善，抑制或改善的疾病或病症的方法。 本发明的方法包括向患者施用特异性结合人IL-4受体的抗体或其抗原结合片段。
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公开(公告)号：US07605237B2
公开(公告)日：2009-10-20
申请号：US11906517
申请日：2007-10-02
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
IPC分类号： C07K16/28
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or antibody fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance.
摘要翻译： 通过表面等离振子共振测量，其具有小于200pM的亲和常数（KD）的人白细胞介素-4受体α（hIL-4Ralpha）的分离的人抗体或其抗体片段。
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公开(公告)号：US20120135010A1
公开(公告)日：2012-05-31
申请号：US13309594
申请日：2011-12-02
申请人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
发明人： Sean Stevens , Tammy T. Huang , Joel H. Martin , Jeanette L. Fairhurst , Ashique Rafique , Marcela Torres , Kevin J. Pobursky , Raymond W. Leidich , Joan A. Windsor , Warren R. Mikulka , Diana M. Ahrens , Ergang Shi , Nicholas J. Papadopoulos
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/21 , C07K2317/73 , C07K2317/76 , C07K2317/92
摘要： An isolated human antibody or antigen binding fragment thereof which binds to human interleukin-4 receptor alpha (hIL-4Rα) with an affinity constant (KD) of less than 200 pM, as measured by surface plasmon resonance, is provided.
摘要翻译： 提供了通过表面等离振子共振测量的以小于200pM的亲和常数（KD）结合人白细胞介素-4受体α（hIL-4Rα）的分离的人抗体或其抗原结合片段。
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公开(公告)号：US20100034833A1
公开(公告)日：2010-02-11
申请号：US12577788
申请日：2009-10-13
申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离的抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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公开(公告)号：US08003103B2
公开(公告)日：2011-08-23
申请号：US12577788
申请日：2009-10-13
申请人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
发明人： Tammy H. Huang , Sean Stevens , Joel H. Martin , Jeanette L. Fairhurst , Kevin J. Pobursky , Margaret Karow , Joan A. Windsor , Warren R. Mikulka
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/76
摘要： An isolated antibody or antibody fragment that binds human interleukin-18 receptor alpha (hIL-18Rα), comprising a light chain variable region (LCVR) selected from the group consisting of SEQ ID NO: 5, 9, 13, 17, 21, 25, 29, 33, 37, 41, 45, 49, 53, 61, 65, 69, 73, 77, and 81 and/or a heavy chain variable region (HCVR) selected from the group consisting of SEQ ID NO: 3, 7, 11, 15, 19, 23, 27, 31, 35, 39, 43, 47, 51, 55, 59, 63, 67, 71, 75, and 79, or a fragment or sequence modified by an amino acid substitution, deletion or addition thereof.
摘要翻译： 一种结合人白细胞介素-18受体α（hIL-18Rα）的分离抗体或抗体片段，其包含选自SEQ ID NO：5,9,13,17,21,25的轻链可变区（LCVR） ，29,33,37,41,45,49,53,61,65,69,73,77和81和/或选自SEQ ID NO：3，SEQ ID NO：3的重链可变区（HCVR） 7,11,15,19,23,27,31,35,39,43,47,51,55,59,63,67,71,75和79，或由氨基酸取代修饰的片段或序列 ，删除或添加。
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