公开(公告)号：US11649288B2

公开(公告)日：2023-05-16

申请号：US16480833

申请日：2018-02-06

申请人： Seattle Children's Hospital

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： A61K47/54 ,  A61K49/00 ,  C07K16/28 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  C07K16/32 ,  A61P35/00 ,  G01N33/569 ,  A61K39/00 ,  C07K14/725

CPC分类号： C07K16/2809 ,  A61K47/544 ,  A61P35/00 ,  C07K16/08 ,  C07K16/12 ,  C07K16/30 ,  C07K16/32 ,  A61K49/0052 ,  A61K2039/5158 ,  C07K14/7051 ,  C07K2317/622 ,  C07K2319/03 ,  C07K2319/33

摘要： Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.

公开(公告)号：US20220257652A1

公开(公告)日：2022-08-18

申请号：US17586067

申请日：2022-01-27

申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute)

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P35/00 ,  A61K9/00 ,  A61K31/365 ,  A61K31/519 ,  A61K38/17 ,  C07K16/44 ,  C07K16/46

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20220125841A1

公开(公告)日：2022-04-28

申请号：US17438231

申请日：2020-03-11

申请人： Seattle Children's Hospital (dba Seattle Children'a Research Institute)

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： A61K35/17 ,  A61P35/00 ,  C07K14/725

摘要： Some embodiments of the methods and compositions provided herein relate to modulating signaling of anti-hapten CAR T cells, such as anti-fluorescein CAR T cells, by the use or administration of an unconjugated hapten, such as unconjugated fluorescein or a salt or derivative thereof.

公开(公告)号：US11779602B2

公开(公告)日：2023-10-10

申请号：US16253562

申请日：2019-01-22

申请人： ENDOCYTE, INC. ,  PURDUE RESEARCH FOUNDATION ,  SEATTLE CHILDREN'S HOSPITAL

发明人： Philip Stewart Low ,  Haiyan Chu ,  Yingjuan June Lu ,  Christopher Paul Leamon ,  Leroy W. Wheeler, II ,  Michael C. Jensen ,  James Matthaei

IPC分类号： A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P35/00 ,  A61K9/00 ,  A61K31/365 ,  A61K31/519 ,  A61K38/17 ,  C07K16/44 ,  C07K16/46

CPC分类号： A61K35/17 ,  A61K9/0019 ,  A61K9/0053 ,  A61K31/365 ,  A61K31/519 ,  A61K38/1774 ,  A61P35/00 ,  C07K14/7051 ,  C07K16/44 ,  C07K16/46 ,  C12N5/0638 ,  C07K2317/622

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US11311576B2

公开(公告)日：2022-04-26

申请号：US16253572

申请日：2019-01-22

申请人： Seattle Children's Hospital

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： C12N15/62 ,  C12P21/00 ,  C07K14/705 ,  C07K16/44 ,  C07K16/46 ,  C12N5/10 ,  A61K38/17 ,  A61K35/17 ,  C07K14/725 ,  C12N5/0783 ,  A61P35/00 ,  A61K9/00 ,  A61K31/365 ,  A61K31/519

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.

公开(公告)号：US20200087399A1

公开(公告)日：2020-03-19

申请号：US16480833

申请日：2018-02-06

申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute)

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： C07K16/28 ,  C07K16/08 ,  C07K16/12 ,  C07K16/32 ,  C07K16/30 ,  A61K47/54

摘要： Aspects of the invention described herein relate to synthetic compounds that are useful for targeting and labeling tumor cells so as to facilitate recognition by binding agents including Chimeric Antigen Receptor T cells (CAR T cells), which are administered to a subject by intravenous or locoregional administration. Several compositions and methods of making and using these compositions to treat or inhibit a disease in a subject are contemplated.

公开(公告)号：US20190224237A1

公开(公告)日：2019-07-25

申请号：US16253572

申请日：2019-01-22

申请人： Seattle Children's Hospital (dba Seattle Children's Research Institute)

发明人： Michael C. Jensen ,  James Matthaei

IPC分类号： A61K35/17 ,  A61P35/00 ,  C12N5/0783 ,  C07K14/725

摘要： The present disclosure relates to methods of treating a patient with a cancer by administering to the patient a composition comprising CAR T cells wherein the CAR T cells comprise a CAR and the CAR comprises an E2 anti-fluorescein antibody fragment, and administering to the patient a small molecule linked to a targeting moiety by a linker. The disclosure also relates to compositions for use in such methods.