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公开(公告)号：US20220169699A1
公开(公告)日：2022-06-02
申请号：US17515250
申请日：2021-10-29
申请人： Sebastian Kobold , Stefan Endres
发明人： Sebastian Kobold , Stefan Endres
IPC分类号： C07K14/705 , A61P35/00 , C12N15/62 , C12N15/85
摘要： The present invention relates to PD-1-CD28 fusion proteins, nucleic acid molecules, vectors, transduced cells carrying nucleic acid molecules or vectors of the present invention or expressing the fusion proteins of the present invention, methods and kits comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention. The invention also provides the use of said transduced cells in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said transduced cells expressing the fusion proteins of the present invention for use in a method of treating of diseases, in particular in the medical intervention of diseases characterized by PD-L1 and/or PD-L2 expression.
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公开(公告)号：US11192935B2
公开(公告)日：2021-12-07
申请号：US15737877
申请日：2016-06-20
申请人： Sebastian Kobold , Stefan Endres
发明人： Sebastian Kobold , Stefan Endres
IPC分类号： C07K14/705 , A61P35/00 , C12N15/62 , C12N15/85
摘要： The present invention relates to PD-1-CD28 fusion proteins, nucleic acid molecules, vectors, transduced cells carrying nucleic acid molecules or vectors of the present invention or expressing the fusion proteins of the present invention, methods and kits comprising the nucleic acid molecules, vectors and/or the fusion proteins of the present invention. The invention also provides the use of said transduced cells in a method for the treatment of particular diseases as well as a pharmaceutical composition/medicament comprising said transduced cells expressing the fusion proteins of the present invention for use in a method of treating of diseases, in particular in the medical intervention of diseases characterized by PD-L1 and/or PD-L2 expression.
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3.发明申请Compositions and methods for inducing an immune response in a mammal and methods of avoiding an immune response to oligonucleotide agents such as short interfering RNAs 有权用于在哺乳动物中诱导免疫应答的组合物和方法以及避免对寡核苷酸试剂例如短干扰RNA的免疫应答的方法公开(公告)号：US20060217330A1
公开(公告)日：2006-09-28
申请号：US11298850
申请日：2005-12-09
CPC分类号： C12N15/117 , A61K39/00 , A61K39/39 , A61K2039/53 , C12N15/1138 , C12N2310/14 , C12N2310/17 , C12N2310/3231
摘要： This invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals.
摘要翻译： 本发明提供了通过刺激IFN产生来调节免疫应答的寡核苷酸试剂以及使用这些试剂用于哺乳动物的治疗处理的方法。
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4.发明授权Method of stimulating an immune response and inhibiting expression of a gene using an oligonucleotide 有权使用寡核苷酸刺激免疫应答并抑制基因表达的方法公开(公告)号：US08003619B2
公开(公告)日：2011-08-23
申请号：US11298850
申请日：2005-12-09
IPC分类号： C12N15/11
CPC分类号： C12N15/117 , A61K39/00 , A61K39/39 , A61K2039/53 , C12N15/1138 , C12N2310/14 , C12N2310/17 , C12N2310/3231
摘要： This invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals.
摘要翻译： 本发明提供了通过刺激IFN产生来调节免疫应答的寡核苷酸试剂以及使用这些试剂用于哺乳动物的治疗处理的方法。
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5.发明申请Compositions and Methods for Inducing an Immune Response in a Mammal and Methods of Avoiding an Immune Response to Oligonucleotide Agents Such as Short Interfering RNAs 审中-公开用于诱导哺乳动物免疫应答的组合物和方法以及避免对诸如短干扰RNA的寡核苷酸药物的免疫应答的方法公开(公告)号：US20120045461A1
公开(公告)日：2012-02-23
申请号：US13179421
申请日：2011-07-08
IPC分类号： A61K31/7088 , A61P37/04 , A61K39/00 , C07H1/06 , C07H21/02
CPC分类号： C12N15/117 , A61K39/00 , A61K39/39 , A61K2039/53 , C12N15/1138 , C12N2310/14 , C12N2310/17 , C12N2310/3231
摘要： Tis invention provides oligonucleotide agents that modulate an immune response by stimulating IFN production and methods of using such agents for therapeutic treatments of mammals.
摘要翻译： 本发明提供了通过刺激IFN产生来调节免疫应答的寡核苷酸试剂和使用这些试剂用于哺乳动物的治疗性处理的方法。
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