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    Nanoparticles of light emissive polymers and preparation method thereof
    1.
    发明授权
    Nanoparticles of light emissive polymers and preparation method thereof 有权
    光发射聚合物纳米颗粒及其制备方法

    公开(公告)号：US08367042B2

    公开(公告)日：2013-02-05

    申请号：US12576193

    申请日：2009-10-08

    申请人： Sehoon Kim ,  Ick Chan Kwon ,  Kwangmeyung Kim ,  Kuiwon Choi ,  Chang-Keun Lim

    发明人： Sehoon Kim ,  Ick Chan Kwon ,  Kwangmeyung Kim ,  Kuiwon Choi ,  Chang-Keun Lim

    IPC分类号： A61B5/00

    CPC分类号： A61K49/0019 ,  A61K49/0093

    摘要： Disclosed are nanoparticles of a light emissive polymer, comprising nanoparticles of a cyano-substituted poly(arylene vinylene) polymer; and a biocompatible surfactant adsorbed to the surface of the nanoparticles of the polymer, and preparation method thereof, wherein the method comprises: (1) uniformly mixing a dialdehyde monomer represented by a general formula OHC—Ar1—CHO, a dicyanide monomer represented by a general formula NC—Ar2—CN, and a liquid surfactant; (2) adding water to the resulting mixture to prepare an aqueous micelle dispersion; and (3) adding a polymerization catalyst to the aqueous micelle dispersion, followed by carrying out colloidal polymerization of the resulting mixture at room temperature under an atmosphere. The nanoparticles of the light emissive polymer of the invention are stabilized with a biocompatible surfactant, so that it can form a stable aqueous dispersion phase, and has particle size and fluorescence efficiency suitable for a biomolecular marker or a cell or in vivo imaging; therefore, it can be used as a cell or in vivo light emission contrast agent.

    摘要翻译： 公开了包含氰基取代的聚（亚芳基亚乙烯基）聚合物的纳米颗粒的发光聚合物的纳米颗粒; 和吸附在聚合物纳米颗粒表面的生物相容性表面活性剂及其制备方法，其中所述方法包括：（1）均匀混合由通式OHC-Ar1-CHO表示的二醛单体，由 通式NC-Ar2-CN和液体表面活性剂; （2）向所得混合物中加入水以制备水性胶束分散体; 和（3）将聚合催化剂加入到水性胶束分散体中，然后在室温下在气氛下进行所得混合物的胶体聚合。 本发明的光发射聚合物的纳米颗粒用生物相容的表面活性剂稳定，从而可以形成稳定的水分散相，并具有适用于生物分子标记或细胞或体内成像的粒度和荧光效率; 因此，它可以用作细胞或体内发光造影剂。