公开(公告)号：US09764069B2

公开(公告)日：2017-09-19

申请号：US14044188

申请日：2013-10-02

Applicant: Semprus Biosciences Corporation

Inventor： Laurence A. Roth ,  Zheng Zhang ,  Chad C. Huval ,  Michael A. Bouchard ,  Christopher R. Loose

IPC: A61L33/00 ,  C09D5/16 ,  A61L33/02 ,  B05D3/10 ,  B05D7/00

CPC classification number: A61L33/0088 ,  A61L33/027 ,  B05D3/10 ,  B05D7/54 ,  C09D5/1693 ,  Y10T428/24802 ,  Y10T428/25 ,  Y10T428/31504 ,  Y10T428/31551 ,  Y10T428/31609

Abstract: Processes are described herein for preparing medical devices and other articles having a low-fouling surface on a substrate comprising a polymeric surface. The polymeric surface material may possess a range of polymeric backbones and substituents while providing the articles with a highly efficient, biocompatible, and non-fouling surface. The processes involve treating the substrate to reduce the concentration of chemical species on the surface of or in the substrate without altering the bulk physical properties of the device or article, and thereafter forming a grafted polymer layer on the treated substrate surface.