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    MEDICAL SUPPLY
    3.
    发明申请
    MEDICAL SUPPLY 审中-公开
    医疗用品

    公开(公告)号：US20140113091A1

    公开(公告)日：2014-04-24

    申请号：US14127061

    申请日：2012-06-22

    申请人： Hirokazu Sakaguchi ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi

    发明人： Hirokazu Sakaguchi ,  Yuka Sakaguchi ,  Kazuhiro Tanahashi

    IPC分类号： A61L33/00

    CPC分类号： A61L33/0041 ,  A61L33/0088 ,  A61L33/06 ,  A61L33/068 ,  C08G65/33331 ,  C08G65/336 ,  C08L2203/02 ,  Y10T428/1352 ,  Y10T428/2935 ,  Y10T428/31667 ,  C08L83/04

    摘要： A medical material has a compound firmly immobilized on the surface thereof, which compound is capable of inhibiting both of the blood coagulation reactions in a primary hemostasis stage in which platelets are involved and in a coagulation thrombus formation stage in which blood coagulation factors are involved in a state retaining the anticoagulant activity. The present invention provides a medical material having a hydrophilic polymer compound immobilized on the surface thereof, in which a compound and a copolymer of monomers selected from the group consisting of ethylene glycol, vinyl acetate, vinyl pyrrolidone, propylene glycol, vinyl alcohol and siloxane are bound.

    摘要翻译： 药物具有牢固地固定在其表面上的化合物，该化合物能够抑制血小板参与的初级止血阶段的凝血反应和参与凝血因子的凝血性血栓形成阶段 保持抗凝活性的状态。 本发明提供一种具有固定在其表面上的亲水性高分子化合物的医用材料，其中选自乙二醇，乙酸乙烯酯，乙烯基吡咯烷酮，丙二醇，乙烯醇和硅氧烷的单体的化合物和共聚物是 界。

    Plasma-deposited coatings, devices and methods
    7.
    发明申请
    Plasma-deposited coatings, devices and methods 审中-公开
    等离子体沉积涂层，器件和方法

    公开(公告)号：US20040126596A1

    公开(公告)日：2004-07-01

    申请号：US10653655

    申请日：2003-09-02

    申请人： BioSurface Engineering Technologies, Inc.

    发明人： Paul O. Zamora ,  Ray Tsang ,  Meng Chen

    IPC分类号： B32B025/20

    CPC分类号： C23C16/0245 ,  A61L29/08 ,  A61L29/085 ,  A61L31/08 ,  A61L31/10 ,  A61L33/0082 ,  A61L33/0088 ,  A61L2420/08 ,  Y10T428/12 ,  Y10T428/12979 ,  Y10T428/31 ,  Y10T428/31663 ,  Y10T428/31667 ,  Y10T428/31678

    摘要： Coatings, devices and methods are provided, wherein the contacting surface of a medical device with at least one contacting surface for contacting a bodily fluid or tissue is modified by plasma treatment in a plasma including nitrogen-containing molecules and oxygen-containing molecules and by application of a biologically compatible coating, preferably by plasma treatment in a plasma including polymerized hydrocyclosiloxane monomers. The nitrogen-containing molecules include NH3, (NH4)null, N2O, NO, NO2 and N2O4, and the oxygen-containing molecules include O2 and O3. The plasma-modified contacting surface exhibits decreased adhesion of at least some mammalian cells, such as platelets and leukocytes, decreased restenosis when used with stents, and increased apoptosis. Additional layers may be applied, including amine-providing groups such as N-trimethylsilyl-allylamine, polyoxyalkylene tethers, and bioactive compounds.

    摘要翻译： 提供了涂层，装置和方法，其中医疗装置的接触表面与用于接触体液或组织的至少一个接触表面通过等离子体处理在包括含氮分子和含氧分子的等离子体中进行修饰，并通过应用 的生物相容性涂层，优选通过在包括聚合的氢氟硅氧烷单体的等离子体中进行等离子体处理。 含氮分子包括NH 3，（NH 4）+，N 2 O，NO，NO 2和N 2 O 4，并且含氧分子包括O 2和O 3。 等离子体修饰的接触表面表现出至少一些哺乳动物细胞（例如血小板和白细胞）的粘附力降低，与支架一起使用时减少的再狭窄以及增加的凋亡。 可以应用另外的层，包括提供胺的基团如N-三甲基甲硅烷基 - 烯丙胺，聚氧化烯系链和生物活性化合物。

    Bioactive surface for titanium implants
    8.
    发明申请
    Bioactive surface for titanium implants 审中-公开
    钛植入物的生物活性表面

    公开(公告)号：US20040091604A1

    公开(公告)日：2004-05-13

    申请号：US10438542

    申请日：2003-05-15

    发明人： Donald J. Dempsey ,  William C. Quist ,  Lori M. Anderson ,  Matthew D. Phaneuf ,  Frank W. LoGerfo

    IPC分类号： A61L002/00

    CPC分类号： A61L33/0088 ,  A61L27/34 ,  A61L27/50 ,  A61L27/54 ,  A61L2300/252 ,  A61L2300/254 ,  A61L2300/414 ,  A61L2300/42 ,  A61L2300/606 ,  C08L83/04

    摘要： The present invention is a broadly applicable methodology for making a bioactive titanium surface which would be clinically-acceptable and effective as either an anti-thrombin, thrombolytic or growth promoting surface coating, or any combination of these. The bioactive surface can be prepared using any material comprising titanium in whole or in part; is suitable for inclusion upon the exposed surfaces of surgically implantable prostheses comprising titanium; offers a means for avoiding systemic anticoagulation therapy to reduce thrombus formation and thromboembolism in the living subject receiving a surgically implanted prosthesis; and provides a means to induce cellular attachment and proliferation onto the titanium surface of the implant.

    摘要翻译： 本发明是用于制备生物活性钛表面的广泛适用的方法，其将作为抗凝血酶，溶栓剂或生长促进性表面包衣或其任何组合在临床上可接受和有效。 生物活性表面可以使用包括钛的全部或部分的任何材料制备; 适于包含在包含钛的手术可植入假体的暴露表面上; 提供了一种避免全身抗凝治疗以减少接受手术植入的假体的活体的血栓形成和血栓栓塞的手段; 并且提供了在植入物的钛表面上诱导细胞附着和增殖的方法。

    Methods for surface modification
    9.
    发明授权
    Methods for surface modification 失效
    表面改性方法

    公开(公告)号：US06632470B2

    公开(公告)日：2003-10-14

    申请号：US09772908

    申请日：2001-01-31

    申请人： Marco Morra ,  Clara Cassinelli ,  Linda Lee Cahalan ,  Patrick T. Cahalan

    发明人： Marco Morra ,  Clara Cassinelli ,  Linda Lee Cahalan ,  Patrick T. Cahalan

    IPC分类号： B05D304

    CPC分类号： A61L33/0094 ,  A61L33/0029 ,  A61L33/0088 ,  C23C16/0245

    摘要： A method of modifying surfaces of a device, for example, a medical device, is disclosed. The method includes modifying a surface of a device by providing a device, exposing the device to a reactive gas and plasma energy to create a plasma deposited surface on the device, and quenching the device with the reactive gas. The device exhibits changes in its surface properties thereby making it more desirable for an intended use.

    摘要翻译： 公开了一种改变设备表面的方法，例如医疗设备。 该方法包括通过提供器件来修饰器件的表面，将器件暴露于反应气体和等离子体能量以在器件上产生等离子体沉积表面，并用反应气体淬火器件。 该装置表现出其表面性质的改变，从而使其更适用于预期用途。

    Process for the surface modification of a polymer substrate and polymers formed therefrom
    10.
    发明申请
    Process for the surface modification of a polymer substrate and polymers formed therefrom 审中-公开
    用于表面改性聚合物基材和由其形成的聚合物的方法

    公开(公告)号：US20020052448A1

    公开(公告)日：2002-05-02

    申请号：US09876572

    申请日：2001-06-07

    发明人： Yading Wang ,  Robert van Boxtel ,  Stephen Q. Zhou

    IPC分类号： C08F002/00

    CPC分类号： A61L33/0029 ,  A61L33/0088 ,  C08J7/16

    摘要： A process for forming a surface modification on a polymer substrate and polymer substrates having such surface modifications. The process comprises the steps of absorbing a swelling monomer into the polymer substrate for a period of time in order to swell the polymer substrate; removing the swollen polymer from the swelling monomer; transferring the swollen polymer to a reaction mixture containing at least one functional monomer; polymerizing the functional monomer in the reaction mixture containing the swollen polymer substrate for a period of time; and removing the polymer from the reaction mixture. Because the surface modification produced by the process is a surface interpenetrating polymer network, the process is not sensitive to the reactive groups located on the surface of the polymer substrate. Further, the surface interpenetrating network bonds to the polymer substrate through caternary connections or other forms of chain entanglement and thus is quite stable. Polymer substrates having the surface modification of the present invention are capable of having a surface modification agent, such as heparin, adhere to the surface of the polymer substrate.

    摘要翻译： 在聚合物基材上形成表面改性的方法和具有这种表面改性的聚合物基材。 该方法包括以下步骤：将溶胀性单体吸收到聚合物基材中一段时间​​以使聚合物基材溶胀; 从溶胀单体中除去溶胀的聚合物; 将溶胀的聚合物转移至含有至少一种官能单体的反应混合物; 在含有溶胀聚合物底物的反应混合物中聚合官能单体一段时间; 并从反应混合物中除去聚合物。 因为该方法产生的表面改性是表面互穿聚合物网络，所以该方法对位于聚合物基材表面上的反应性基团不敏感。 此外，表面互穿网络通过亲子连接或其他形式的链缠结而结合到聚合物基底，因此是相当稳定的。 具有本发明的表面改性的聚合物基材能够具有表面改性剂，例如肝素，附着在聚合物基材的表面上。