公开(公告)号：US20230331705A1

公开(公告)日：2023-10-19

申请号：US17999254

申请日：2021-05-19

申请人： Senda Biosciences, Inc.

发明人： Alessandra Bartolozzi ,  John Robert Proudfoot ,  Timothy Briggs ,  John Mancuso ,  Maxence Bos ,  Vu Linh Ly ,  Anna Blois ,  Bernard Lanter ,  Steven John Taylor ,  Leonard Buckbinder

IPC分类号： C07D403/12 ,  A61K45/06 ,  C07D235/18 ,  A61P35/04

CPC分类号： C07D403/12 ,  A61K45/06 ,  C07D235/18 ,  A61P35/04

摘要： The present disclosure relates to compounds of formulae (I)-(VI) and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.

公开(公告)号：US20230234967A1

公开(公告)日：2023-07-27

申请号：US17999443

申请日：2021-05-27

申请人： Senda Biosciences, Inc.

发明人： Alessandra Bartolozzi ,  John Robert Proudfoot ,  Timothy Briggs ,  John Mancuso ,  Maxence Bos ,  Tianlin Guo ,  Vu Linh Ly ,  Anna Blois ,  Bernard Lanter ,  Steven John Taylor ,  Leonard Buckbinder

IPC分类号： C07D513/04 ,  C07D498/04 ,  C07D471/04 ,  C07D487/04 ,  A61P35/00 ,  A61P1/00 ,  A61K39/395 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/519 ,  A61K31/4985

CPC分类号： C07D513/04 ,  C07D498/04 ,  C07D471/04 ,  C07D487/04 ,  A61P35/00 ,  A61P1/00 ,  A61K39/3955 ,  A61K31/437 ,  A61K31/444 ,  A61K31/5377 ,  A61K31/496 ,  A61K31/519 ,  A61K31/4985

摘要： The present disclosure relates to thiazolo-pyridine, oxazolo-pyridine, pyrrolo-pyridine, pyrrolo-pyrazine and pyrrolo-pyrimidine compounds and pharmaceutically acceptable salts thereof, pharmaceutical compositions comprising the same, methods of preparing the same, intermediate compounds useful for preparing the same, and methods for treating or prophylaxis of diseases, in particular cancer or conditions with dysregulated immune responses or other disorders associated with aberrant AHR signaling.