公开(公告)号：US20230272037A1

公开(公告)日：2023-08-31

申请号：US17820804

申请日：2022-08-18

申请人： Senti Biosciences, Inc.

发明人： Russell Morrison Gordley ,  Marcela Guzman Ayala ,  Gary Lee ,  Nicholas Frankel

IPC分类号： C07K14/725 ,  C07K14/705 ,  C07K14/47 ,  C12N15/63

CPC分类号： C07K14/7051 ,  C07K14/70596 ,  C07K14/4703 ,  C07K14/70521 ,  C12N15/63 ,  C07K2319/03 ,  C07K2319/02 ,  C07K2317/622 ,  C07K2317/55

摘要： Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.

公开(公告)号：US20240173410A1

公开(公告)日：2024-05-30

申请号：US18504037

申请日：2023-11-07

申请人： Senti Biosciences, Inc.

发明人： Alba Gonzalez-Junca ,  Nicholas Frankel ,  Assen Boyanov Roguev

IPC分类号： A61K39/00 ,  C07K14/725 ,  C07K16/28

CPC分类号： A61K39/464411 ,  A61K39/4613 ,  A61K39/4631 ,  C07K14/7051 ,  C07K16/2803 ,  C07K2317/622 ,  C07K2319/03

摘要： Provided herein are chimeric proteins comprising an antigen-binding domain specific for V-Set And Immunoglobulin Domain Containing 2 (VSIG2). Also provided herein are cells, polynucleotides, vectors, compositions, and methods directed to chimeric proteins comprising an antigen-binding domain specific for VSIG2.

公开(公告)号：US20220289842A1

公开(公告)日：2022-09-15

申请号：US17636301

申请日：2020-08-20

申请人： Senti Biosciences, Inc.

发明人： Russell Morrison Gordley ,  Nicholas Frankel

IPC分类号： C07K16/28 ,  C07K14/705 ,  C12N9/12 ,  A61K35/17

摘要： Provided herein are chimeric inhibitory receptor constructs and compositions, and cells comprising the same. Also provided are methods of using chimeric inhibitory receptor constructs and compositions, and cells comprising the same.

公开(公告)号：US20230235051A1

公开(公告)日：2023-07-27

申请号：US17820525

申请日：2022-08-17

申请人： Senti Biosciences, Inc. ,  TRUSTEES OF BOSTON UNIVERSITY

发明人： Wilson Wong ,  Seunghee Lee ,  Russell Morrison Gordley ,  Marcela Guzman Ayala ,  Gary Lee ,  Nicholas Frankel ,  Xi Kang

IPC分类号： C07K16/28 ,  C07K14/725 ,  C07K14/705 ,  A61K39/00 ,  C07K16/32

CPC分类号： C07K16/2803 ,  C07K14/7051 ,  C07K14/70517 ,  C07K14/70521 ,  A61K39/4611 ,  A61K39/4621 ,  A61K39/4631 ,  A61K39/4643 ,  A61K39/4613 ,  C07K16/32 ,  A61K39/464406 ,  C07K2319/02 ,  C07K2319/03 ,  C07K2317/622 ,  C07K2319/43 ,  A61K2239/13 ,  A61K2239/21 ,  A61K2239/22

摘要： Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.