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公开(公告)号：US20210189367A1
公开(公告)日：2021-06-24
申请号：US16771510
申请日：2018-12-11
IPC分类号： C12N9/50 , C07K14/705 , C12N5/0783 , A61K35/17 , C07K16/32 , C07K16/28
摘要： The present disclosure provides inducible cell receptors and therapeutic cells comprising the inducible cell receptors. Further provided are methods of preparing the therapeutic cells and methods of treating a subject by administering the therapeutic cells and regulating activity of (e.g. activating and/or inactivating) the cell receptors.
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公开(公告)号：US20230235051A1
公开(公告)日：2023-07-27
申请号：US17820525
申请日：2022-08-17
发明人： Wilson Wong , Seunghee Lee , Russell Morrison Gordley , Marcela Guzman Ayala , Gary Lee , Nicholas Frankel , Xi Kang
IPC分类号： C07K16/28 , C07K14/725 , C07K14/705 , A61K39/00 , C07K16/32
CPC分类号： C07K16/2803 , C07K14/7051 , C07K14/70517 , C07K14/70521 , A61K39/4611 , A61K39/4621 , A61K39/4631 , A61K39/4643 , A61K39/4613 , C07K16/32 , A61K39/464406 , C07K2319/02 , C07K2319/03 , C07K2317/622 , C07K2319/43 , A61K2239/13 , A61K2239/21 , A61K2239/22
摘要： Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
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公开(公告)号：US20230272037A1
公开(公告)日：2023-08-31
申请号：US17820804
申请日：2022-08-18
IPC分类号： C07K14/725 , C07K14/705 , C07K14/47 , C12N15/63
CPC分类号： C07K14/7051 , C07K14/70596 , C07K14/4703 , C07K14/70521 , C12N15/63 , C07K2319/03 , C07K2319/02 , C07K2317/622 , C07K2317/55
摘要： Provided herein are inhibitory chimeric antigen receptor compositions and cells comprising such compositions. Also provided are methods of using inhibitory chimeric antigen receptors and cells.
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公开(公告)号：US20230270789A1
公开(公告)日：2023-08-31
申请号：US17872827
申请日：2022-07-25
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang
IPC分类号： A61K35/28 , A61P35/00 , A61K39/395
CPC分类号： A61K35/28 , A61P35/00 , A61K39/3955 , A61K2039/5156
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US20210228640A1
公开(公告)日：2021-07-29
申请号：US17219569
申请日：2021-03-31
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang , Daniel Frimannsson
IPC分类号： A61K35/28 , A61P35/00 , C07K14/715 , C12N5/0775 , C12N15/63
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US10993967B2
公开(公告)日：2021-05-04
申请号：US16656452
申请日：2019-10-17
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang , Daniel Frimannsson
IPC分类号： A61K35/28 , A61P35/00 , C07K14/715 , C12N5/0775 , C12N15/63 , C07K16/28 , C07K16/30
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US20240277765A1
公开(公告)日：2024-08-22
申请号：US18501925
申请日：2023-11-03
发明人： Brian Scott Garrison , Jennifer Chien , Kathryn Armstrong Loving , Russell Morrison Gordley , Michelle Elizabeth Hung
IPC分类号： A61K35/17 , A61K38/00 , C07K14/725 , C07K16/28
CPC分类号： A61K35/17 , C07K14/7051 , C07K16/2803 , C07K16/2863 , A61K38/00 , C07K2317/565 , C07K2317/622 , C07K2319/03
摘要： Provided herein are acute myeloid leukemia antigen targets for chimeric receptors and methods of using same.
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公开(公告)号：US20240226296A9
公开(公告)日：2024-07-11
申请号：US18377191
申请日：2023-10-05
发明人： Michelle Elizabeth Hung , Rebecca Tayler Cottman , Russell Morrison Gordley , Gary Lee , Timothy Kuan-Ta Lu , Srinivasaraghavan Kannan , Chandra Shekhar Verma
IPC分类号： A61K39/00
CPC分类号： A61K39/4635 , A61K39/4613 , A61K39/463
摘要： Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
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公开(公告)号：US20200171093A1
公开(公告)日：2020-06-04
申请号：US16656452
申请日：2019-10-17
发明人： Timothy Kuan-Ta Lu , Russell Morrison Gordley , Jack Tzu-Chiao Lin , Brian Scott Garrison , Philip Janmin Lee , Alba Gonzalez-Junca , Don-Hong Wang , Daniel Frimannsson
IPC分类号： A61K35/28 , C12N5/0775 , C12N15/63 , C07K14/715 , A61P35/00
摘要： Provided herein are methods and compositions for dynamically controlling and targeting multiple immunosuppressive mechanisms in cancer. Some aspects provide cells engineered to produce multiple effector molecules, each of which modulates a different immunosuppressive mechanisms of a tumor, as well as methods of using the cells to treat cancer, such as ovarian, breast, or colon cancer.
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公开(公告)号：US20240150433A1
公开(公告)日：2024-05-09
申请号：US18481805
申请日：2023-10-05
发明人： Michelle Elizabeth Hung , Rebecca Tayler Cottman , Russell Morrison Gordley , Gary Lee , Timothy Kuan-Ta Lu , Srinivasaraghavan Kannan , Chandra Shekhar Verma
IPC分类号： C07K14/72 , C07K14/715 , C12N15/85
CPC分类号： C07K14/721 , C07K14/7155 , C12N15/85 , C07K2319/09 , C12N2800/107 , C12N2830/002
摘要： Provided herein are mutants of estrogen receptor alpha ligand binding domain (ER-LBD), and chimeric proteins including such mutant ER-LBD. Also provided are methods of modulating transcription and modulating localization of such chimeric proteins.
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