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公开(公告)号：US07777077B2
公开(公告)日：2010-08-17
申请号：US12012161
申请日：2008-01-31
申请人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert M. McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert M. McKinnell , Vivek Sasikumar
IPC分类号： C07C239/00 , C07D257/00
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，及其药学上可接受的盐。 式I的化合物具有AT1受体拮抗剂活性和去皮质激素抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08394846B2
公开(公告)日：2013-03-12
申请号：US13361099
申请日：2012-01-30
申请人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，及其药学上可接受的盐。 式I的化合物具有AT1受体拮抗剂活性和去皮质激素抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08735625B2
公开(公告)日：2014-05-27
申请号：US13755404
申请日：2013-01-31
申请人： Seok-ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： C07C239/00 , C07D257/00
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，及其药学上可接受的盐。 式I的化合物具有AT1受体拮抗剂活性和去皮质激素抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US20140046075A1
公开(公告)日：2014-02-13
申请号：US13755404
申请日：2013-01-31
申请人： Seok-ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： C07D257/04 , C07C319/12
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，及其药学上可接受的盐。 式I的化合物具有AT1受体拮抗剂活性和去皮质激素抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US20080188533A1
公开(公告)日：2008-08-07
申请号：US12012161
申请日：2008-01-31
申请人： Seok-Ki Choi , Paul R. Fatheree , Sharath Hegde , Ryan Hudson , Keith Jendza , Daniel Marquess , Robert M. McKinnel , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Sharath Hegde , Ryan Hudson , Keith Jendza , Daniel Marquess , Robert M. McKinnel , Vivek Sasikumar
IPC分类号： A61K31/41 , C07C233/51 , A61K31/165 , A61P9/12 , G01N33/566 , C07D257/04
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，和药学上可接受的盐 其中。 式I的化合物具有AT 1受体拮抗剂活性和尿丙氨酸抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08143298B2
公开(公告)日：2012-03-27
申请号：US12826976
申请日：2010-06-30
申请人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Ryan Hudson , Keith Jendza , Robert Murray McKinnell , Vivek Sasikumar
CPC分类号： C07C237/20 , C07C243/32 , C07C319/12 , C07C323/22 , C07C323/41 , C07C323/60 , C07C2601/14 , C07D257/04
摘要： The invention is directed to compounds of formula I: wherein Ar, r, R3, X, and R5-7 are as defined in the specification, and pharmaceutically acceptable salts thereof. The compounds of formula I have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention is also directed to pharmaceutical compositions comprising such compounds; methods of using such compounds; and a process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及式I化合物：其中Ar，r，R 3，X和R 5-7如说明书中所定义，及其药学上可接受的盐。 式I的化合物具有AT1受体拮抗剂活性和去皮质激素抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US07834041B2
公开(公告)日：2010-11-16
申请号：US12231858
申请日：2008-09-05
申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07C323/60 , C07C259/06 , C07D207/16 , C07D257/04 , C07D403/12
摘要： The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及具有下式的化合物：其中：Ar，r，R3，Z，X和R5-7如说明书中所定义，或其药学上可接受的盐。 这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08106082B2
公开(公告)日：2012-01-31
申请号：US12898999
申请日：2010-10-06
申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07C323/60 , C07C259/06 , C07D207/16 , C07D257/04 , C07D403/12
摘要： The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
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公开(公告)号：US20090093417A1
公开(公告)日：2009-04-09
申请号：US12231858
申请日：2008-09-05
申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： A61K38/05 , C07D257/04 , C07D403/12 , A61K31/4025
CPC分类号： C07C323/60 , C07C259/06 , C07D207/16 , C07D257/04 , C07D403/12
摘要： The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及具有下式的化合物：其中：Ar，r，R3，Z，X和R5-7如说明书中所定义，或其药学上可接受的盐。 这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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公开(公告)号：US08236839B2
公开(公告)日：2012-08-07
申请号：US13330372
申请日：2011-12-19
申请人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
发明人： Seok-Ki Choi , Paul R. Fatheree , Roland Gendron , Ryan Hudson , Robert Murray McKinnell , Vivek Sasikumar
IPC分类号： A61K31/41 , C07D257/04
CPC分类号： C07C323/60 , C07C259/06 , C07D207/16 , C07D257/04 , C07D403/12
摘要： The invention relates to compounds having the formula: wherein: Ar, r, R3, Z, X, and R5-7 are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have AT1 receptor antagonist activity and neprilysin inhibition activity. The invention also relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and process and intermediates for preparing such compounds.
摘要翻译： 本发明涉及具有下式的化合物：其中：Ar，r，R3，Z，X和R5-7如说明书中所定义，或其药学上可接受的盐。 这些化合物具有AT1受体拮抗剂活性和neprilysin抑制活性。 本发明还涉及包含这些化合物的药物组合物; 使用这些化合物的方法; 以及制备这些化合物的方法和中间体。
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