公开(公告)号：US20030149304A1

公开(公告)日：2003-08-07

申请号：US10238204

申请日：2002-09-10

Applicant: Sepracor Inc.

Inventor： Gerald J. Tanoury ,  Chris H. Senanayake ,  Donald W. Kessler

IPC: A61K031/137 ,  C07C217/30

CPC classification number: A61K31/205 ,  C07B2200/13 ,  C07C231/24 ,  C07C233/25 ,  C07C233/43

Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.

Abstract translation: 公开了制备R，R-福莫特醇L-酒石酸盐的高纯度盐的方法。 该方法通过重结晶新型多晶型物提供最热力学稳定的多晶型物。

公开(公告)号：US20040176450A1

公开(公告)日：2004-09-09

申请号：US10806993

申请日：2004-03-23

Applicant: SEPRACOR INC.

Inventor： Gerald J. Tanoury ,  Chris H. Senanayake ,  Donald W. Kessler

IPC: A61K031/205 ,  C07C215/46

CPC classification number: A61K31/205 ,  C07B2200/13 ,  C07C231/24 ,  C07C233/25 ,  C07C233/43

Abstract: A method of preparation of a highly pure salt of R,R-formoterol L-tartrate is disclosed. The process provides the most thermodynamically stable polymorph by recrystallization of a novel polymorph.

Abstract translation: 公开了制备R，R-福莫特醇L-酒石酸盐的高纯度盐的方法。 该方法通过重结晶新型多晶型物提供最热力学稳定的多晶型物。

公开(公告)号：US20030130321A1

公开(公告)日：2003-07-10

申请号：US10325686

申请日：2002-12-20

Applicant: Sepracor, Inc.

Inventor： Chris H. Senanayake ,  Gerald J. Tanoury ,  Harold S. Wilkinson ,  Roger P. Bakale ,  Andrei A. Zlota

IPC: C07D213/46 ,  C07D211/82 ,  A01N043/40

CPC classification number: C07D211/90

Abstract: The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,Nnull-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.

Abstract translation: 本发明涉及通过在非水溶剂如N，N'-二甲基乙酰胺的存在下用酒石酸沉淀来将外消旋氨氯地平拆分成对映异构体富集的组合物的方法。 酒石酸：氨氯地平的摩尔比优选小于0.25:1.0或大于0.75:1.0。