公开(公告)号：US20030100581A1

公开(公告)日：2003-05-29

申请号：US09907556

申请日：2001-07-17

Applicant: SEPRACOR INC.

Inventor： Roger P. Bakale ,  Chris Senanayake ,  Yaping Hong ,  Kostas Saranteas ,  Martin P. Redmon ,  Stephen A. Wald

IPC: A61K031/454 ,  C07D43/02

CPC classification number: C07D401/12

Abstract: Polymorphic crystalline forms of the antihistaminic drug norastemizole are disclosed. Processes for the production of the preferred polymorph are also disclosed.

Abstract translation: 公开了抗组胺药物诺尔阿司咪唑的多晶型形式。 还公开了制备优选多晶型物的方法。

公开(公告)号：US20030130321A1

公开(公告)日：2003-07-10

申请号：US10325686

申请日：2002-12-20

Applicant: Sepracor, Inc.

Inventor： Chris H. Senanayake ,  Gerald J. Tanoury ,  Harold S. Wilkinson ,  Roger P. Bakale ,  Andrei A. Zlota

IPC: C07D213/46 ,  C07D211/82 ,  A01N043/40

CPC classification number: C07D211/90

Abstract: The invention relates to methods of resolving racemic amlodipine into enantiomerically enriched compositions by precipitation with tartaric acid in the presence of a non-aqueous solvent, such as N,Nnull-dimethylacetamide. The molar ratio of tartaric acid:amlodipine is preferably less than 0.25:1.0 or greater than 0.75:1.0.

Abstract translation: 本发明涉及通过在非水溶剂如N，N'-二甲基乙酰胺的存在下用酒石酸沉淀来将外消旋氨氯地平拆分成对映异构体富集的组合物的方法。 酒石酸：氨氯地平的摩尔比优选小于0.25:1.0或大于0.75:1.0。