公开(公告)号：US12176067B2

公开(公告)日：2024-12-24

申请号：US16597707

申请日：2019-10-09

Applicant: Sequenom, Inc.

Inventor： Sung K. Kim ,  Cosmin Deciu

IPC: G16B20/20 ,  G16B30/00 ,  G16B30/10

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US11697849B2

公开(公告)日：2023-07-11

申请号：US13754817

申请日：2013-01-30

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Mathias Ehrich ,  Dirk J. van den Boom ,  Zeljko Dzakula

IPC: C40B20/00 ,  C12Q1/6883

CPC classification number: C12Q1/6883 ,  C12Q2600/156

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US09984198B2

公开(公告)日：2018-05-29

申请号：US13797930

申请日：2013-03-12

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  Mathias Ehrich ,  Taylor Jacob Jensen

IPC: G06F19/18 ,  C12Q1/68 ,  G06F19/22

CPC classification number: G06F19/18 ,  C12Q1/6883 ,  C12Q2600/156 ,  G06F19/22

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20140180594A1

公开(公告)日：2014-06-26

申请号：US13782883

申请日：2013-03-01

Applicant: SEQUENOM, INC.

Inventor： Sung K. Kim ,  Cosmin Deciu

IPC: G06F19/22

CPC classification number: G16B30/00 ,  Y02A90/26

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract translation: 本文提供了用于遗传变异的非侵入性评估的方法，过程和装置。

公开(公告)号：US20140100792A1

公开(公告)日：2014-04-10

申请号：US13781530

申请日：2013-02-28

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  Amin Mazloom

IPC: G06F19/24 ,  G06F19/22

CPC classification number: G16B40/00 ,  C12Q1/6869 ,  C12Q1/6883 ,  C12Q2545/101 ,  C12Q2545/114 ,  G16B30/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US11560586B2

公开(公告)日：2023-01-24

申请号：US16395658

申请日：2019-04-26

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Jovan Dzakula ,  Mathias Ehrich ,  Sung Kyun Kim

IPC: C12Q1/6827 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/10 ,  G16H50/20

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US11462298B2

公开(公告)日：2022-10-04

申请号：US16862324

申请日：2020-04-29

Applicant: SEQUENOM, INC.

Inventor： Chen Zhao ,  Zeljko Dzakula ,  Cosmin Deciu ,  Sung Kyun Kim ,  Amin R. Mazloom ,  Gregory Hannum ,  Mathias Ehrich

IPC: G16B20/10 ,  C12Q1/6869 ,  C12Q1/6883 ,  G16B30/10 ,  G16B30/00 ,  G16B40/00 ,  G16B25/10

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of decision analyses. The decision analyses sometimes include segmentation analyses and/or odds ratio analyses.

公开(公告)号：US11365447B2

公开(公告)日：2022-06-21

申请号：US15124324

申请日：2015-03-12

Applicant: SEQUENOM, INC.

Inventor： Taylor Jacob Jensen ,  Jennifer Geis ,  Sung Kyun Kim ,  Cosmin Deciu ,  Mathias Ehrich

IPC: C12Q1/6883 ,  G16B25/00 ,  G16B45/00 ,  G16B25/10 ,  G16B25/20 ,  H01J49/16

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations. In particular the invention relates to methods and kits for detecting aneuploidy of a fetal chromosome by determining the amounts of differentially methylated regions in each of chromosomes 13, 18 and 21 in circulating cell-free nucleic acid from a human pregnant female.

公开(公告)号：US10196681B2

公开(公告)日：2019-02-05

申请号：US13829164

申请日：2013-03-14

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  John Allen Tynan ,  Grant Hogg

IPC: C12Q1/683 ,  G06F19/18 ,  C12Q1/6827 ,  G06F19/00 ,  C12Q1/68

Abstract: Provided herein are methods, processes and apparatuses for determining the fraction of fetal nucleic acid in a test sample derived from a pregnant female with improved accuracy and/or precision. Also, provided herein are methods, processes and apparatuses for determining the presence or absence of a genetic variation in a fetus with improved accuracy and/or precision. Certain methods include using fetal fraction measurements for the determination of a fetal genetic variation.

公开(公告)号：US20180282801A1

公开(公告)日：2018-10-04

申请号：US15965350

申请日：2018-04-27

Applicant: Sequenom, Inc.

Inventor： Chen Zhao ,  Cosmin Deciu

IPC: C12Q1/6869 ,  G06F19/00 ,  G16H50/30 ,  C12Q1/6827 ,  G06F19/18 ,  G06F19/22 ,  G06F19/24

Abstract: Technology described herein pertains in part to diagnostic tests that make use of sequence reads generated by a sequencing process. In some embodiments, a component used to generate a chromosome representation can be based on counts of sequence reads not aligned to a reference genome.