公开(公告)号：US11515003B2

公开(公告)日：2022-11-29

申请号：US15661942

申请日：2017-07-27

Applicant: Sequenom, Inc.

Inventor： Youting Sun ,  Sung Kyun Kim ,  Mathias Ehrich ,  Christopher Ellison ,  Taylor Jensen ,  Amin Mazloom

IPC: G16B20/10 ,  G16B20/00 ,  G16B20/20 ,  G16B10/00

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genomic nucleic acid instability and genomic nucleic acid stability. The method comprises providing a set of genomic portions each coupled to a copy number alteration quantification for a test sample, wherein the genomic portions comprises portions of a reference genome to which sequence reads obtained for nucleic acid from a test sample obtained from the subject have been mapped, and the copy number alteration quantification coupled to each genomic portion has been determined from a quantification of sequence reads mapped to the genomic portion; and determining, by a computing device, presence or absence of genomic instability for the subject according to the copy number alteration quantifications coupled to the genomic portions.

公开(公告)号：US20220411871A1

公开(公告)日：2022-12-29

申请号：US17751201

申请日：2022-05-23

Applicant: Sequenom, Inc.

Inventor： Taylor Jacob Jensen ,  Jennifer Geis ,  Sung Kyun Kim ,  Cosmin Deciu ,  Mathias Ehrich

IPC: C12Q1/6883 ,  G16B25/00 ,  G16B45/00 ,  G16B25/10 ,  G16B25/20

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US11001884B2

公开(公告)日：2021-05-11

申请号：US15647148

申请日：2017-07-11

Applicant: SEQUENOM, INC.

Inventor： Dirk Johannes Van Den Boom ,  Charles R. Cantor ,  Sung Kyun Kim ,  Zeljko Dzakula ,  Cosmin Deciu

IPC: C12Q1/6869 ,  G16B20/00 ,  C12Q1/6827 ,  G16B30/00 ,  G16B40/00

Abstract: Technology provided herein relates in part to methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20230187021A1

公开(公告)日：2023-06-15

申请号：US18045279

申请日：2022-10-10

Applicant: Sequenom, Inc.

Inventor： Youting Sun ,  Sung Kyun Kim ,  Mathias Ehrich ,  Christopher Ellison ,  Taylor Jensen ,  Amin Mazloom

IPC: G16B20/10 ,  G16B20/00 ,  G16B20/20

CPC classification number: G16B20/10 ,  G16B20/00 ,  G16B20/20 ,  G16B10/00

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genomic nucleic acid instability and genomic nucleic acid stability.

公开(公告)号：US10699800B2

公开(公告)日：2020-06-30

申请号：US14892782

申请日：2014-05-23

Applicant: SEQUENOM, INC.

Inventor： Chen Zhao ,  Zeljko Dzakula ,  Cosmin Deciu ,  Sung Kyun Kim ,  Amin R. Mazloom ,  Gregory Hannum ,  Mathias Ehrich

IPC: G16B20/10 ,  C12Q1/6883 ,  C12Q1/6869 ,  G16B30/00 ,  G16B40/00

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of decision analyses. The decision analyses sometimes include segmentation analyses and/or odds ratio analyses.

公开(公告)号：US10323268B2

公开(公告)日：2019-06-18

申请号：US15149045

申请日：2016-05-06

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Jovan Dzakula ,  Mathias Ehrich ,  Sung Kyun Kim

IPC: G16B20/00 ,  G16B30/10 ,  G16H50/20 ,  C12Q1/6827

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US20180032666A1

公开(公告)日：2018-02-01

申请号：US15661942

申请日：2017-07-27

Applicant: Sequenom, Inc.

Inventor： Youting Sun ,  Sung Kyun Kim ,  Mathias Ehrich ,  Christopher Ellison ,  Taylor Jensen ,  Amin Mazloom

IPC: G06F19/18

CPC classification number: G16B20/00 ,  G16B10/00

Abstract: Technology provided herein relates in part to methods, processes, machines and apparatuses for non-invasive assessment of genomic nucleic acid instability and genomic nucleic acid stability.

公开(公告)号：US09367663B2

公开(公告)日：2016-06-14

申请号：US13669136

申请日：2012-11-05

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Dzakula ,  Mathias Ehrich ,  Sung Kyun Kim

IPC: G06F19/00 ,  G06F15/00 ,  G06F19/18 ,  C12Q1/68

CPC classification number: C12Q1/6827 ,  G06F19/18 ,  C12Q2537/16 ,  C12Q2537/165

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

Abstract translation: 本文提供了用于遗传变异的非侵入性评估的方法，过程和装置。

公开(公告)号：US11560586B2

公开(公告)日：2023-01-24

申请号：US16395658

申请日：2019-04-26

Applicant: SEQUENOM, INC.

Inventor： Cosmin Deciu ,  Zeljko Jovan Dzakula ,  Mathias Ehrich ,  Sung Kyun Kim

IPC: C12Q1/6827 ,  G16B20/00 ,  G16B20/10 ,  G16B20/20 ,  G16B30/10 ,  G16H50/20

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations.

公开(公告)号：US11462298B2

公开(公告)日：2022-10-04

申请号：US16862324

申请日：2020-04-29

Applicant: SEQUENOM, INC.

Inventor： Chen Zhao ,  Zeljko Dzakula ,  Cosmin Deciu ,  Sung Kyun Kim ,  Amin R. Mazloom ,  Gregory Hannum ,  Mathias Ehrich

IPC: G16B20/10 ,  C12Q1/6869 ,  C12Q1/6883 ,  G16B30/10 ,  G16B30/00 ,  G16B40/00 ,  G16B25/10

Abstract: Provided herein are methods, processes and apparatuses for non-invasive assessment of genetic variations that make use of decision analyses. The decision analyses sometimes include segmentation analyses and/or odds ratio analyses.