公开(公告)号：US20080183285A1

公开(公告)日：2008-07-31

申请号：US12031652

申请日：2008-02-14

Applicant: Emanuel Shaoulian ,  Samuel Shaolian ,  Shahram Moaddeb ,  Richard S. Rhee

Inventor： Emanuel Shaoulian ,  Samuel Shaolian ,  Shahram Moaddeb ,  Richard S. Rhee

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2448 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2210/009 ,  A61F2250/0001 ,  A61F2250/0004

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion more than a distance between the two lateral portions.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离超过两个侧向部分之间的距离。

公开(公告)号：US20050288776A1

公开(公告)日：2005-12-29

申请号：US11123851

申请日：2005-05-06

Applicant: Emanuel Shaoulian ,  Samuel Shaolian ,  Shahram Moaddeb

Inventor： Emanuel Shaoulian ,  Samuel Shaolian ,  Shahram Moaddeb

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include a tubular member configured to be attached to or near a cardiac valve annulus. The tubular member includes a receptacle end and an insert end configured to couple with the receptacle end of the tubular member such that the tubular member substantially forms a shape of a ring. The insert end is configured to move with respect to the receptacle end to change a circumference of the ring.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，这些装置包括构造成附接到心脏瓣膜环上或附近的管状构件。 管状构件包括容置端和插入端，所述插入端构造成与管状构件的容置端相连，使得管状构件基本上形成环的形状。 插入端构造成相对于插座端移动以改变环的圆周。

公开(公告)号：US20050288780A1

公开(公告)日：2005-12-29

申请号：US11124405

申请日：2005-05-06

Applicant: Richard Rhee ,  Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： Richard Rhee ,  Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/00 ,  A61F2/02 ,  A61F2/24

CPC classification number: A61F2/2448 ,  A61F2/2445 ,  A61F2210/0014 ,  A61F2210/0023 ,  A61F2250/0001 ,  A61F2250/0004 ,  A61F2250/0082

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have, a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置中的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。

公开(公告)号：US20080228272A1

公开(公告)日：2008-09-18

申请号：US11950407

申请日：2007-12-04

Applicant: Shahram Moaddeb ,  Samuel Shaolian

Inventor： Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/08

CPC classification number: A61F2/2457

Abstract: Embodiments of a dynamically adjustable artificial chordae tendinae implant are described. In some embodiments the implant includes a body portion, including an adjustable portion. In some embodiments, the implant includes a plurality of adjustable portions. In some embodiments the adjustable element can include a shape memory material. The adjustable portion can be configured to transform from a first conformation to a second conformation in response to an activation energy. In some embodiments, the activation energy can be one of electromagnetic energy, acoustic energy, light energy, thermal energy, electrical energy, mechanical energy, or a combination of energies. The implant couples a heart valve leaflet to a papillary muscle. Activation of the shape memory material regulates tension between the muscle and valve leaflet improving coaptation of heart valve leaflets, and reducing or eliminating regurgitation.

Abstract translation: 描述了动态调节的人造腱索植入物的实施例。 在一些实施例中，植入物包括主体部分，其包括可调部分。 在一些实施例中，植入物包括多个可调部分。 在一些实施例中，可调元件可以包括形状记忆材料。 可调节部分可以被配置为响应于活化能量从第一构象转变成第二构象。 在一些实施例中，激活能可以是电磁能，声能，光能，热能，电能，机械能或能量的组合中的一种。 植入物将心脏瓣膜小叶结合到乳头肌。 形状记忆材料的激活调节肌肉和瓣膜瓣之间的张力，改善心脏瓣膜小叶的接合，并减少或消除反流。

公开(公告)号：US20080051840A1

公开(公告)日：2008-02-28

申请号：US11773311

申请日：2007-07-03

Applicant: Shahram Moaddeb ,  Samuel Shaolian ,  Emanuel Shaoulian

Inventor： Shahram Moaddeb ,  Samuel Shaolian ,  Emanuel Shaoulian

IPC: A61N1/368

CPC classification number: A61N1/3627

Abstract: Systems, methods and devices are provided for improving the hemodynamic efficiency of a patient's heart by implanting one or more reinforcement elements on or with the heart and providing electrical stimulation to the heart. The reinforcement elements may include magnetic and/or shape memory material and are configured to reshape the heart so as to boost the heart's mechanical energy during a response to the electrical stimulation. In some embodiments, at least one reinforcement element includes an electrode configured to sense electrocardiogram signals within the heart. An electrical stimulation device such as an implantable or external pacemaker/defibrillator may be configured to control delivery of electrical pulses to the heart based on the sensed electrocardiogram signals. In addition, or in other embodiments, at least one reinforcement element includes an electrode configured to deliver the electrical pulses to the heart.

Abstract translation: 提供了系统，方法和装置，用于通过在心脏上或与心脏一起植入一个或多个增强元件并向心脏提供电刺激来改善患者心脏的血液动力学效率。 加强元件可以包括磁性和/或形状的记忆材料，并且被配置成重塑心脏，以便在对电刺激的响应期间增强心脏的机械能。 在一些实施例中，至少一个加强元件包括被配置为感测心脏内的心电图信号的电极。 诸如植入式或外部起搏器/除颤器之类的电刺激装置可以被配置成基于感测到的心电图信号来控制向心脏的电脉冲的传递。 另外或在其它实施例中，至少一个加强元件包括被配置为将电脉冲传送到心脏的电极。

公开(公告)号：US20070239154A1

公开(公告)日：2007-10-11

申请号：US11728010

申请日：2007-03-22

Applicant: Samuel Shaolian ,  Shahram Moaddeb ,  Maurice Buchbinder ,  David Zarbatany ,  Jason Tran

Inventor： Samuel Shaolian ,  Shahram Moaddeb ,  Maurice Buchbinder ,  David Zarbatany ,  Jason Tran

IPC: A61F2/24 ,  A61B18/18

CPC classification number: A61F2/2445 ,  A61F2/2466 ,  A61F2250/0001

Abstract: An activation device for applying energy to an implanted annuloplasty ring is described. In some embodiments, the activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween. In some embodiments, the activation device further includes an inner elongate member having a inner elongate member distal end and a inner elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one energy-transfer element coupled to the adjustable spline.

Abstract translation: 描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。 在一些实施例中，激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔。 在一些实施例中，激活装置还包括具有内部细长构件远端和内部细长构件近端的内部细长构件和其间的内腔，其中内部细长构件可滑动地插入穿过外部细长构件的内腔。 在一些实施例中，激活装置还包括具有花键近端和花键远端的至少一个可调节花键，花键远端连接到内部管状构件远端，花键近端连接到外部管状构件远端，其中， 当内部细长构件驻留在外部细长构件的内腔中时，可调节花键构造成随着内部管状构件远端朝向外部管状构件远端被拉近而弯曲。 在一些实施例中，激活装置还包括耦合到可调节花键的至少一个能量传递元件。

公开(公告)号：US20060241747A1

公开(公告)日：2006-10-26

申请号：US11123874

申请日：2005-05-06

Applicant: Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： Emanuel Shaoulian ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/24 ,  A61F2/86

CPC classification number: A61F2/2451 ,  A61F2250/0001 ,  A61F2250/0039

Abstract: Tissue shaping methods and devices are provided. The devices can be adjusted within the body of a patient in a less invasive or non-invasive manner, such as by applying energy percutaneously or external to the patient's body. In one example, the device is positioned within the coronary sinus of the patient so as to effect changes in at least one dimension of the mitral valve annulus. The device may also advantageously include a shape memory material that is responsive to changes in temperature and/or exposure to a magnetic field. In one example, the shape memory material is responsive to energy, such as electromagnetic or acoustic energy, applied from an energy source located outside the coronary sinus. A material having enhanced absorption characteristics with respect to the desired heating energy may also be used to facilitate heating and adjustment of the tissue shaping device.

Abstract translation: 提供组织成形方法和装置。 可以以侵入性或非侵入性方式在患者体内调节装置，例如通过经皮或外部给予患者身体的能量。 在一个示例中，装置定位在患者的冠状窦内，以便实现二尖瓣环的至少一个维度的变化。 该装置还可以有利地包括响应温度变化和/或暴露于磁场的形状记忆材料。 在一个示例中，形状记忆材料响应于从位于冠状窦外侧的能量源施加的能量，例如电磁或声能。 相对于期望的加热能量具有增强的吸收特性的材料也可用于促进组织整形装置的加热和调节。

公开(公告)号：US20110230962A1

公开(公告)日：2011-09-22

申请号：US12941918

申请日：2010-11-08

Applicant: Shahram Moaddeb ,  Samuel Shaolian

Inventor： Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2457

Abstract: Embodiments of a dynamically adjustable artificial chordae tendinae implant are described. In some embodiments the implant includes a body portion, including an adjustable portion. In some embodiments, the implant includes a plurality of adjustable portions. In some embodiments the adjustable element can include a shape memory material. The adjustable portion can be configured to transform from a first conformation to a second conformation in response to an activation energy. In some embodiments, the activation energy can be one of electromagnetic energy, acoustic energy, light energy, thermal energy, electrical energy, mechanical energy, or a combination of energies. The implant couples a heart valve leaflet to a papillary muscle. Activation of the shape memory material regulates tension between the muscle and valve leaflet improving coaptation of heart valve leaflets, and reducing or eliminating regurgitation.

Abstract translation: 描述了动态调节的人造腱索植入物的实施例。 在一些实施例中，植入物包括主体部分，其包括可调部分。 在一些实施例中，植入物包括多个可调部分。 在一些实施例中，可调元件可以包括形状记忆材料。 可调节部分可以被配置为响应于活化能量从第一构象转变成第二构象。 在一些实施例中，激活能可以是电磁能，声能，光能，热能，电能，机械能或能量的组合中的一种。 植入物将心脏瓣膜小叶结合到乳头肌。 形状记忆材料的激活调节肌肉和瓣膜瓣之间的张力，改善心脏瓣膜小叶的接合，并减少或消除反流。

公开(公告)号：US07536228B2

公开(公告)日：2009-05-19

申请号：US11728010

申请日：2007-03-22

Applicant: Samuel Shaolian ,  Shahram Moaddeb ,  Maurice Buchbinder ,  David Zarbatany ,  Jason Tran

Inventor： Samuel Shaolian ,  Shahram Moaddeb ,  Maurice Buchbinder ,  David Zarbatany ,  Jason Tran

IPC: A61N1/18

CPC classification number: A61F2/2445 ,  A61F2/2466 ,  A61F2250/0001

Abstract: An activation device for applying energy to an implanted annuloplasty ring is described. In some embodiments, the activation device includes an outer elongate member having an outer elongate member distal end and an outer elongate member proximal end, and a lumen therebetween. In some embodiments, the activation device further includes an inner elongate member having a inner elongate member distal end and a inner elongate member proximal end, and a lumen therebetween, wherein the inner elongate member is slidably insertable through the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one adjustable spline having spline proximal and spline distal ends, the spline distal end connected to the inner tubular member distal end and the spline proximal end connected to the outer tubular member distal end, wherein the adjustable spline is configured to flex as the inner tubular member distal end is drawn proximally toward the outer tubular member distal end while the inner elongate member resides in the lumen of the outer elongate member. In some embodiments, the activation device further includes at least one energy-transfer element coupled to the adjustable spline.

Abstract translation: 描述了一种用于向植入的瓣膜成形术环施加能量的激活装置。 在一些实施例中，激活装置包括具有外部细长构件远端和外部细长构件近端的外部细长构件和其间的内腔。 在一些实施例中，激活装置还包括具有内部细长构件远端和内部细长构件近端的内部细长构件和其间的内腔，其中内部细长构件可滑动地插入穿过外部细长构件的内腔。 在一些实施例中，激活装置还包括具有花键近端和花键远端的至少一个可调节花键，花键远端连接到内部管状构件远端，花键近端连接到外部管状构件远端，其中， 当内部细长构件驻留在外部细长构件的内腔中时，可调节花键构造成随着内部管状构件远端朝向外部管状构件远端被拉近而弯曲。 在一些实施例中，激活装置还包括耦合到可调节花键的至少一个能量传递元件。

公开(公告)号：US20080015688A1

公开(公告)日：2008-01-17

申请号：US11881336

申请日：2007-07-25

Applicant: James Hill ,  Shahram Moaddeb ,  Samuel Shaolian

Inventor： James Hill ,  Shahram Moaddeb ,  Samuel Shaolian

IPC: A61F2/24

CPC classification number: A61F2/2445 ,  A61F2/2448 ,  A61F2250/0004

Abstract: Methods and devices are provided for support of a body structure. The devices can be adjusted within the body of a patient in a minimally invasive or non-invasive manner such as by applying energy percutaneously or external to the patient's body. The energy may include, for example, acoustic energy, radio frequency energy, light energy and magnetic energy. Thus, as the body structure changes size and/or shape, the size and/or shape of the annuloplasty rings can be adjusted to provide continued reinforcement. In certain embodiments, the devices include an anterior portion, a posterior portion and two lateral portions corresponding to intersections of the anterior portion and the posterior portion. The devices have a first shape in a first configuration and a second shape in a second configuration and are configured to transform from the first configuration to the second configuration in response to an activation energy applied thereto. The transformation is configured to reduce a distance between the anterior portion and the posterior portion without substantially decreasing a distance between the two lateral portions.

Abstract translation: 提供了用于支撑身体结构的方法和装置。 可以以微创或非侵入性方式在患者体内调节装置，例如通过经皮或外部给患者的身体施加能量。 能量可以包括例如声能，射频能量，光能和磁能。 因此，随着身体结构改变尺寸和/或形状，可以调节瓣膜成形术环的尺寸和/或形状以提供持续的加强。 在某些实施例中，装置包括前部，后部和对应于前部和后部的交叉点的两个侧部。 这些装置具有第一配置的第一形状和第二配置的第二形状，并且被配置为响应于施加到其上的激活能量而从第一配置变换到第二配置。 该变换被配置为减小前部和后部之间的距离，而基本上不减小两个侧部之间的距离。