公开(公告)号：US20090215908A1

公开(公告)日：2009-08-27

申请号：US12236402

申请日：2008-09-23

申请人： Shakti Upadhyay ,  Yogesh Kanekar ,  Rajendra Kshirsagar ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

发明人： Shakti Upadhyay ,  Yogesh Kanekar ,  Rajendra Kshirsagar ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

IPC分类号： A61K31/09 ,  C07C43/295 ,  C12N5/06 ,  A61P35/00 ,  C12Q1/02

CPC分类号： C07C43/23 ,  C07C43/20 ,  C07C69/157 ,  C07C69/73 ,  C07C2603/26

摘要： The present invention relates to novel synthetic toll like receptor antagonist. The present invention in particular provides compounds, methods and compositions for specifically inhibiting immune stimulation involving TLR ligands, especially TLR-4. The compounds are potentially useful in treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

摘要翻译： 本发明涉及新的合成通道类受体拮抗剂。 本发明特别提供用于特异性抑制涉及TLR配体，特别是TLR-4的免疫刺激的化合物，方法和组合物。 这些化合物可用于治疗炎症，自身免疫，过敏，哮喘，移植排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

公开(公告)号：US20070054958A1

公开(公告)日：2007-03-08

申请号：US11222901

申请日：2005-09-08

申请人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

发明人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

IPC分类号： C07C50/04 ,  A61K31/275 ,  A61K31/215 ,  A61K31/13 ,  A61K31/26

CPC分类号： C07C50/28 ,  C07C69/76 ,  C07C69/78 ,  C07C205/57

摘要： Novel benzoquinone-derived compounds and polymorphs, prodrugs, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, and metabolic disorders are provided. Methods of use of the compounds for skin care, hair care and cosmetics are provided.

摘要翻译： 提供了新的苯醌衍生化合物及其多晶型物，前体药物，几何或光学异构体，以及这些化合物的药学上可接受的酯，醚，氨基甲酸酯，肟，多晶型物，前体药物和异构体。 制备本发明化合物的方法和含有这些化合物的药物组合物及其用于降低或抑制脂肪酶基因家族用于治疗，改善或预防脂肪酶基因家族介导的疾病和病症（包括超重，肥胖，高脂血症，高胆固醇血症，高甘油三酯血症 ，胰腺炎，糖尿病，动脉粥样硬化，其他心血管疾病，代谢综合征和代谢紊乱。 提供了化合物用于护肤，护发和化妆品的方法。

公开(公告)号：US07355055B2

公开(公告)日：2008-04-08

申请号：US11222901

申请日：2005-09-08

申请人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

发明人： Shakti Upadhyay ,  Raman Yadav ,  Vijay Gangan ,  Yogesh Kanekar

IPC分类号： C07C50/04 ,  C07C69/74 ,  A01N43/02

CPC分类号： C07C50/28 ,  C07C69/76 ,  C07C69/78 ,  C07C205/57

摘要： Novel benzoquinone-derived compounds and polymorphs, prodrugs, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, and metabolic disorders are provided. Methods of use of the compounds for skin care, hair care and cosmetics are provided.

摘要翻译： 提供了新的苯醌衍生化合物及其多晶型物，前体药物，几何或光学异构体，以及这些化合物的药学上可接受的酯，醚，氨基甲酸酯，肟，多晶型物，前体药物和异构体。 制备本发明化合物的方法和含有这些化合物的药物组合物及其用于降低或抑制脂肪酶基因家族用于治疗，改善或预防脂肪酶基因家族介导的疾病和病症（包括超重，肥胖，高脂血症，高胆固醇血症，高甘油三酯血症 ，胰腺炎，糖尿病，动脉粥样硬化，其他心血管疾病，代谢综合征和代谢紊乱。 提供了化合物用于护肤，护发和化妆品的方法。