公开(公告)号：US20090215908A1

公开(公告)日：2009-08-27

申请号：US12236402

申请日：2008-09-23

申请人： Shakti Upadhyay ,  Yogesh Kanekar ,  Rajendra Kshirsagar ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

发明人： Shakti Upadhyay ,  Yogesh Kanekar ,  Rajendra Kshirsagar ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

IPC分类号： A61K31/09 ,  C07C43/295 ,  C12N5/06 ,  A61P35/00 ,  C12Q1/02

CPC分类号： C07C43/23 ,  C07C43/20 ,  C07C69/157 ,  C07C69/73 ,  C07C2603/26

摘要： The present invention relates to novel synthetic toll like receptor antagonist. The present invention in particular provides compounds, methods and compositions for specifically inhibiting immune stimulation involving TLR ligands, especially TLR-4. The compounds are potentially useful in treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer and immunodeficiency.

摘要翻译： 本发明涉及新的合成通道类受体拮抗剂。 本发明特别提供用于特异性抑制涉及TLR配体，特别是TLR-4的免疫刺激的化合物，方法和组合物。 这些化合物可用于治疗炎症，自身免疫，过敏，哮喘，移植排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。

公开(公告)号：US20090215710A1

公开(公告)日：2009-08-27

申请号：US12236358

申请日：2008-09-23

申请人： Shakti Upadhyay ,  Ashwani Sharma ,  Anuradha Sharma ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

发明人： Shakti Upadhyay ,  Ashwani Sharma ,  Anuradha Sharma ,  Vikram Rajagopal ,  Praneel Datla ,  Akshaya Bellary ,  Shiva Prasad Singh

IPC分类号： A61K31/7028 ,  C07H5/06 ,  C12N5/06 ,  C12Q1/02

CPC分类号： C07H5/04 ,  C07H15/06 ,  C07H15/10 ,  C07H15/12

摘要： The invention provides carbohydrate based compounds, methods of preparation, and compositions useful for modulating signaling through Toll-like receptors. The methods involve contacting a TLR-expressing cell with a carbohydrate based compound of the invention having a core structure comprising of one or more sugar moieties. The carbohydrate based compounds are useful for inhibiting immune stimulation involving TLR ligands, especially TLR4 and TLR2. The compounds also are suitable for inhibition of inflammatory conditions resulting from infections. The compounds have use in the treatment of inflammation, autoimmunity, allergy, asthma, graft rejection, graft versus host disease, infection, sepsis, cancer, and immunodeficiency.

摘要翻译： 本发明提供了基于碳水化合物的化合物，制备方法和用于通过Toll样受体调节信号传导的组合物。 所述方法包括使表达TLR的细胞与具有包含一个或多个糖部分的核心结构的本发明的基于碳水化合物的化合物接触。 基于碳水化合物的化合物可用于抑制涉及TLR配体，特别是TLR4和TLR2的免疫刺激。 所述化合物还适用于抑制由感染引起的炎性病症。 该化合物可用于治疗炎症，自身免疫，过敏，哮喘，移植物排斥，移植物抗宿主病，感染，败血症，癌症和免疫缺陷。