Factor IXa for the treatment of bleeding disorders
    1.
    发明授权
    Factor IXa for the treatment of bleeding disorders 有权
    因子IXa用于治疗出血性疾病

    公开(公告)号:US07425539B2

    公开(公告)日:2008-09-16

    申请号:US11068596

    申请日:2005-02-28

    IPC分类号: A61K38/00

    CPC分类号: A61K38/36 A61K38/4846

    摘要: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.

    摘要翻译: 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法,该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物,从而降低受试者中不期望的副作用的发生率。

    Method of the invention preparations of factor IXa
    5.
    发明授权
    Method of the invention preparations of factor IXa 有权
    本发明的方法制备因子IXa

    公开(公告)号:US07767647B2

    公开(公告)日:2010-08-03

    申请号:US12221086

    申请日:2008-07-30

    IPC分类号: A61K38/00

    CPC分类号: A61K38/36 A61K38/4846

    摘要: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.

    摘要翻译: 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法,该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物,从而降低受试者中不期望的副作用的发生率。

    Factor IXa for the treatment of bleeding disorders
    6.
    发明申请
    Factor IXa for the treatment of bleeding disorders 有权
    因子IXa用于治疗出血性疾病

    公开(公告)号:US20090069543A1

    公开(公告)日:2009-03-12

    申请号:US12221086

    申请日:2008-07-30

    IPC分类号: C07K14/745

    CPC分类号: A61K38/36 A61K38/4846

    摘要: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.

    摘要翻译: 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法,该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物,从而降低受试者中不期望的副作用的发生率。

    Factor IXa for the treatment of bleeding disorders
    7.
    发明申请
    Factor IXa for the treatment of bleeding disorders 有权
    因子IXa用于治疗出血性疾病

    公开(公告)号:US20050209149A1

    公开(公告)日:2005-09-22

    申请号:US11068596

    申请日:2005-02-28

    IPC分类号: A61K38/36 A61K38/48

    CPC分类号: A61K38/36 A61K38/4846

    摘要: The invention provides a method of treating bleeding disorders in a subject by administration of a preparation enriched for Factor IXa. The Factor IXa can be produced by proteolytically activating recombinantly-produced Factor IX. The invention also provides an improved method for producing Factor IXa from a plasma fraction, which method results in a Factor IXa product containing little or no prekallikrein activity, thus reducing the incidence of undesired side effects in a subject.

    摘要翻译: 本发明提供了通过施用富含因子IXa的制剂来治疗受试者的出血性疾病的方法。 因子IXa可以通过蛋白水解激活重组产生的因子IX产生。 本发明还提供了用于从血浆部分制备因子IXa的改进方法,该方法产生含有很少或不具有前激肽释放酶活性的因子IXa产物,从而降低受试者中不期望的副作用的发生率。