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公开(公告)号:US20220389025A1
公开(公告)日:2022-12-08
申请号:US17761252
申请日:2020-09-21
申请人: Shanghai Institute of Materia Medica, Chinese Academy of Sciences , China Pharmaceutical University
发明人: Wenhu DUAN , Meiyu GENG , Huibin ZHANG , Zuoquan XIE , Jinpei ZHOU , Yifei YANG , Xiyuan WANG , Xiaojun YANG , Yan ZHANG , Zhaoxue HU , Jian DING
IPC分类号: C07D491/048 , C07D519/00 , A61P35/00
摘要: Provided are a heterocyclic amide compound of general formula (I), a pharmaceutically acceptable salt thereof and a preparation method therefor, and the use of the compound in the preparation of a drug for treating diseases related to the activity of STING, in the preparation of an immunologic adjuvant, and in the preparation of a drug for activating STING.
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公开(公告)号:US20230032101A1
公开(公告)日:2023-02-02
申请号:US17772334
申请日:2020-10-23
发明人: Wenhu DUAN , Meiyu GENG , Zhengsheng ZHAN , Zuoquan XIE , Kaiyan ZHAO , Yuting GUO , Xiyuan WANG , Yan ZHANG , Xiaoqian ZHOU , Jian DING
IPC分类号: C07D409/04 , C07D405/04 , C07D333/22 , C07D407/04 , C07D495/04 , C07D417/04 , C07D471/04 , C07D409/14 , A61P35/00
摘要: A five-membered heterocyclic oxocarboxylic acid compound and the medical use thereof are described. Specifically, provided are a compound as represented by formula (I) and a pharmaceutically acceptable salt, prodrug, hydrate, solvate or crystal form thereof, and also a method for preparing the compound, a pharmaceutical composition containing the compound, and the medical use thereof as a secretion regulator of type I interferon, especially as a STING agonist, and the preparation of a drug for preventing and/or treating diseases related to type I interferon.
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公开(公告)号:US20220089561A1
公开(公告)日:2022-03-24
申请号:US17420389
申请日:2019-12-31
申请人: SHANGHAI HAIHE PHARMACEUTICAL CO., LTD. , Shanghai Institute of Materia Medica, Chinese Academy of Sciences
发明人: Ao ZHANG , Meiyu GENG , Chunyong DING , Zuoquan XIE , Jian DING , Yan ZHANG , Ancheng SHEN , Xiyuan WANG
IPC分类号: C07D333/64 , C07D409/12
摘要: A fluorine-containing substituted benzothiophene compound and a pharmaceutical composition and an application thereof are described. The compound has the structure as shown in formula (I), in which the definitions of each group and substituent are as described in the description. A preparation method of the compound and an anti-tumor application thereof are also described.
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